INT7023

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Context Info
Confidence 0.05
First Reported 1990
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.10
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd1a, Npr1) intracellular (Drd1a, Npr1) endoplasmic reticulum (Drd1a)
nucleus (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
hypothalamus 2
Drd1a (Rattus norvegicus)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dopamine receptor 5 100.00 Very High Very High Very High
Enkephalin 6 99.60 Very High Very High Very High
Nucleus accumbens 6 98.94 Very High Very High Very High
agonist 6 97.72 Very High Very High Very High
mu opioid receptor 3 97.36 Very High Very High Very High
Dopamine 10 97.30 Very High Very High Very High
Delta opioid receptors 1 90.40 High High
antagonist 4 82.16 Quite High
opioid receptor 3 81.36 Quite High
narcan 2 78.40 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D1 dopamine receptor-stimulated adenylate cyclase activity was also slightly reduced (by approximately 20%) by high concentrations of the kappa-agonist U50,488 (EC50 = 0.63 microM).
Negative_regulation (reduced) of D1 dopamine receptor-stimulated Positive_regulation (stimulated) of cyclase associated with dopamine receptor and agonist
1) Confidence 0.05 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2168934 Disease Relevance 0 Pain Relevance 1.02
In slices of rat nucleus accumbens, olfactory tubercle, frontal cortex and mediobasal hypothalamus exposed to dopamine (DA), the activation of DA D1 receptors stimulated cyclic AMP (cAMP) formation whereas, in nucleus accumbens slices only, activation of D2 receptors appeared to inhibit D1 receptor-stimulated adenylate cyclase at the same time.
Negative_regulation (inhibit) of D1 receptor Positive_regulation (stimulated) of cyclase in hypothalamus associated with nucleus accumbens, dopamine and urological neuroanatomy
2) Confidence 0.03 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1337044 Disease Relevance 0.10 Pain Relevance 0.79

General Comments

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