INT70248

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Context Info
Confidence 0.13
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (G2e3) Golgi apparatus (G2e3) intracellular (G2e3)
cytoplasm (G2e3)
Anatomy Link Frequency
blood 2
plasma 2
G2e3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 19 98.76 Very High Very High Very High
antinociception 1 94.00 High High
Antinociceptive 5 79.00 Quite High
tail-flick 1 41.20 Quite Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 2 71.72 Quite High
Diabetes Mellitus 2 52.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: In STZ-diabetic rats, the distribution volume of morphine increased, the glucuronidation rate and M3G transportation into the blood were enhanced, and the excretion of M3G was decreased, leading to an increase in the plasma M3G concentration.


Positive_regulation (leading) of Positive_regulation (increase) of M3G in blood
1) Confidence 0.13 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487213 Disease Relevance 0.05 Pain Relevance 0
Accumulation of M3G in plasma of aged rats is probably due to diminished renal clearance of M3G in addition to a reduction in the biliary excretion of M3G.
Spec (probably) Positive_regulation (due) of Positive_regulation (Accumulation) of M3G in plasma
2) Confidence 0.05 Published 1997 Journal Pain Section Abstract Doc Link 9211481 Disease Relevance 0.12 Pain Relevance 0.94

General Comments

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