INT7025

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Context Info
Confidence 0.04
First Reported 1992
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd1a, Npr1) intracellular (Drd1a, Npr1) endoplasmic reticulum (Drd1a)
nucleus (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
brain 2
Drd1a (Rattus norvegicus)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 9 99.60 Very High Very High Very High
Nucleus accumbens 6 98.40 Very High Very High Very High
Enkephalin 3 94.72 High High
Delta opioid receptors 1 93.20 High High
mu opioid receptor 1 89.60 High High
agonist 1 86.00 High High
opioid receptor 2 75.00 Quite High
narcan 1 59.76 Quite High
Opioid 2 53.68 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When adenylate cyclase was stimulated by selective D1 receptor activation, i.e. by DA in the presence of (-)-sulpiride, DPDPE reduced cAMP formation (by about 45%) in nucleus accumbens slices but not in slices of the other brain regions.
Positive_regulation (activation) of D1 receptor in brain Positive_regulation (stimulated) of cyclase associated with nucleus accumbens and dopamine
1) Confidence 0.04 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1337044 Disease Relevance 0.08 Pain Relevance 1.01

General Comments

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