INT70252

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 3.89
Pain Relevance 7.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a6) enzyme binding (Ugt1a6) protein complex (Ugt1a6)
Anatomy Link Frequency
sensory neurons 1
CAR 1
red nucleus 1
arcuate nucleus 1
CPA 1
Ugt1a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 298 100.00 Very High Very High Very High
antagonist 31 100.00 Very High Very High Very High
Morphine 13 100.00 Very High Very High Very High
Glutamate 10 99.90 Very High Very High Very High
dorsal root ganglion 34 99.84 Very High Very High Very High
cytokine 17 99.56 Very High Very High Very High
Inflammation 150 99.38 Very High Very High Very High
Paracetamol 18 99.20 Very High Very High Very High
gABA 26 98.66 Very High Very High Very High
cINOD 4 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 35 99.84 Very High Very High Very High
Periodontitis 60 99.72 Very High Very High Very High
Injury 18 99.66 Very High Very High Very High
INFLAMMATION 163 99.38 Very High Very High Very High
Chronic Renal Insufficiency 9 98.44 Very High Very High Very High
Nociception 35 95.00 High High
Pressure And Volume Under Development 22 79.60 Quite High
Depression 6 61.92 Quite High
Pain 18 55.32 Quite High
Spinal Cord Injury 2 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, this endotoxin-induced increase in UGT1A6 expression level was blocked by actinomycin D and cycloheximide, indicating the requirement for RNA and protein synthesis.
Gene_expression (expression) of UGT1A6
1) Confidence 0.77 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.49 Pain Relevance 0.36
None of the 3 inhibitors of APAP glucuronidation were able to alter the expression of UGT1A6, UGT1A7 and UGT1A8 (the major isoforms responsible for APAP glucuronidation in the rat), however, their efficacy at inhibiting APAP glucuronidation was proportional to their capacity to deplete UDP-glucuronic acid (UDPGA).
Gene_expression (expression) of UGT1A6 associated with paracetamol
2) Confidence 0.68 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18708084 Disease Relevance 0 Pain Relevance 0.90
The UGT1A6 expression enhancement could be prevented by anti-inflammatory drugs (dexamethasone and NS398) or nitric oxide synthase inhibitors (L-NAME and L-NMMA).
Gene_expression (expression) of UGT1A6 associated with inflammation, cinod and dexamethasone
3) Confidence 0.67 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.48 Pain Relevance 0.37
Taken together, these results indicate that nutritional status may gender-specifically influence the expression and activation of CAR and PPARalpha in liver cell nuclei, and this effect appears to be associated with alterations in UGT1A1 and UGT1A6 expression.
Gene_expression (expression) of UGT1A6 in CAR
4) Confidence 0.67 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.26
Although we observed the expression of other UGT isoforms, such as UGT1A1, UGT1A6, and UGT1A7, in the fetus (Figure 6C), the results of the UGT activity assay strongly suggested that the fetus has low ability to metabolize BPA due to a deficiency in UGT2B1.
Gene_expression (expression) of UGT1A6
5) Confidence 0.63 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.08
On the other hand, the fetal UGT activity toward 1-NA was higher than that toward BPA, and we observed abundant expression of UGT1A6, which is known to glucuronidate 1-NA, in fetal tissues.
Gene_expression (expression) of UGT1A6
6) Confidence 0.63 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.07
There was no significant difference between CRI and CPF rats in hepatic and/or renal E2-3G (UGT1A1), E2-17G (UGT2B3), 4-MUG (UGT1A6), and M3G (UGT2B1) formation.
Gene_expression (formation) of UGT1A6 associated with chronic renal insufficiency and morphine
7) Confidence 0.60 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16415115 Disease Relevance 0.61 Pain Relevance 0.27
Messenger RNA and protein levels of UGT1A1 and UGT1A6 in the liver but not the jejunum were increased in male rats fed the HF1 diet.
Gene_expression (levels) of UGT1A6 in jejunum
8) Confidence 0.52 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0
In these cells, the evoked autaptic GABA release (inhibitory postsynaptic current) was significantly inhibited by adenosine (37%), CPA (27%), and DPMA (28%), indicating that both A1 and A2 receptors were present in presynaptic axons.
Gene_expression (present) of A1 in CPA associated with adenocard and gaba
9) Confidence 0.49 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9212255 Disease Relevance 0 Pain Relevance 1.00
We conclude that both adenosine A1 and A2 receptors are present in the SCN and arcuate nucleus of the hypothalamus.
Gene_expression (present) of A1 in SCN associated with adenocard
10) Confidence 0.33 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9212255 Disease Relevance 0 Pain Relevance 0.77
Caffeine, an adenosine A1 and A2 receptors antagonist, reverted the T. avellanedae aqueous extract action at the formalin test second phase (Nemenyi: q0.05;?
Gene_expression (antagonist) of A1 associated with adenocard and antagonist
11) Confidence 0.24 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC56902 Disease Relevance 0.28 Pain Relevance 0.27
Caffeine, an adenosine A1 and A2 receptors antagonist, reverted the T. avellanedae aqueous extract action at the formalin test second phase (Nemenyi: q0.05;?
Gene_expression (adenosine) of A1 associated with adenocard and antagonist
12) Confidence 0.24 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC56902 Disease Relevance 0.27 Pain Relevance 0.28
Annexin A1 and A3 were differently expressed in DRG sensory neurons [19].
Gene_expression (expressed) of A1 in sensory neurons associated with dorsal root ganglion
13) Confidence 0.18 Published 2009 Journal Proteome Sci Section Body Doc Link PMC2780401 Disease Relevance 0.35 Pain Relevance 0.31
These include genes encoding GAD65 GABA synthesis enzyme, anti-inflammatory cytokine, IL-10, and GABAB1d, A1 adenosine, ?
Gene_expression (adenosine) of A1 associated with adenocard, gaba, inflammation and cytokine
14) Confidence 0.18 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.66 Pain Relevance 0.70
We conclude that both adenosine A1 and A2 receptors are present in the SCN and arcuate nucleus of the hypothalamus.
Gene_expression (present) of A1 in arcuate nucleus associated with adenocard
15) Confidence 0.11 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9212255 Disease Relevance 0 Pain Relevance 0.77
In contrast Hypericum treatment prevented the periodontitis-mediated iNOS expression (Figure 6a, a1).
Gene_expression (expression) of a1 associated with periodontitis
16) Confidence 0.06 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.22 Pain Relevance 0.03
In contrast Hypericum treatment prevented the periodontitis-mediated Bax expression (Figure 7a, a1).
Gene_expression (expression) of a1 associated with periodontitis
17) Confidence 0.05 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.17 Pain Relevance 0
Ramkumar et al. pretreated DDT1 MF-2 cells, a smooth muscle cell line expressing both A1 and A2A receptors, with R-phenylisopropyl adenosine (R-PIA) for up to 24 h, after which the adenylyl cyclase activity was reduced by approximately 50%.
Gene_expression (expressing) of A1 in smooth muscle cell associated with adenocard
18) Confidence 0.05 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.31
However increasing A1 concentration to 25 ?
Gene_expression (concentration) of A1
19) Confidence 0.04 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513146 Disease Relevance 0 Pain Relevance 0
The most likely source of the adenosine is the excitatory terminals (which release glutamate and express the A1 receptors) and thus the adenosine acts to depress excitatory synaptic transmission (and presumably its own release) via autoreceptors [62].


Gene_expression (express) of A1 associated with glutamate and adenocard
20) Confidence 0.04 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701281 Disease Relevance 0.06 Pain Relevance 0.59

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