INT70253

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 16.31
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
reticulum 10
heart 4
neuronal 2
cardiomyocytes 2
spikes 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 6 99.52 Very High Very High Very High
nMDA receptor 55 99.48 Very High Very High Very High
5HT 5 99.44 Very High Very High Very High
Neuronal excitability 5 98.68 Very High Very High Very High
ischemia 136 98.32 Very High Very High Very High
Inflammation 15 97.04 Very High Very High Very High
imagery 30 96.80 Very High Very High Very High
Action potential 51 96.28 Very High Very High Very High
qutenza 496 94.04 High High
chemokine 4 93.92 High High
Disease Link Frequency Relevance Heat
Brain Injury 249 100.00 Very High Very High Very High
Hypoxia 1610 99.92 Very High Very High Very High
Myocardial Infarction 58 99.82 Very High Very High Very High
Diabetes Mellitus 83 99.76 Very High Very High Very High
Ganglion Cysts 6 99.52 Very High Very High Very High
Apoptosis 90 99.28 Very High Very High Very High
Cv Unclassified Under Development 238 98.32 Very High Very High Very High
INFLAMMATION 16 97.04 Very High Very High Very High
Acidosis 870 92.32 High High
Injury 285 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting showed that diabetic rats had a reduced expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)2a, with no difference in expression of the Na+/Ca2+ exchanger.
Negative_regulation (reduced) of Gene_expression (expression) of Ca2 in reticulum associated with diabetes mellitus
1) Confidence 0.49 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494698 Disease Relevance 1.00 Pain Relevance 0.08
Anoxia also reduced both sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity and Ca2+ extrusion [probably via plasma membrane Ca2+-ATPase (PMCA)].
Negative_regulation (reduced) of Gene_expression (extrusion) of Ca2 in reticulum associated with hypoxia
2) Confidence 0.42 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.78 Pain Relevance 0.10
Similar results were also obtained when both CPA, an inhibitor of the endoplasmic reticulum Ca2+ pump (SERCA), and caffeine were used together to deplete Ca2+ stores; i.e., the rise in [Ca2+]i in response to anoxia was reduced (to 21 ± 3.4 nM, n = 7, P < 0.001), but was not abolished (Fig. 3).
Negative_regulation (deplete) of Gene_expression (stores) of Ca2 in reticulum associated with hypoxia
3) Confidence 0.36 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.79 Pain Relevance 0
Anoxia (3 min) reduced this SERCA-mediated Ca2+ clearance to 6.2 nM/s or ?
Negative_regulation (reduced) of Gene_expression (clearance) of Ca2 associated with hypoxia
4) Confidence 0.36 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.61 Pain Relevance 0
Anoxia also reduced both sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity and Ca2+ extrusion [probably via plasma membrane Ca2+-ATPase (PMCA)].
Negative_regulation (reduced) of Gene_expression (extrusion) of Ca2 in reticulum associated with hypoxia
5) Confidence 0.36 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.78 Pain Relevance 0.10
Note that ryanodine did not deplete ER stores of Ca2+ (as evidenced by the observation that after removal of ryanodine, caffeine evoked a large rise in [Ca2+]i, Fig. 4D) but none the less reduced Ca2+ release in response to anoxia.


Negative_regulation (deplete) of Gene_expression (stores) of Ca2 associated with hypoxia
6) Confidence 0.36 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.53 Pain Relevance 0
Effects of anoxia on cytosolic Ca2+ clearance
Negative_regulation (cytosolic) of Gene_expression (clearance) of Ca2 associated with hypoxia
7) Confidence 0.36 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.35 Pain Relevance 0
Anoxia also reduced both sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity and Ca2+ extrusion [probably via plasma membrane Ca2+-ATPase (PMCA)].
Negative_regulation (reduced) of Gene_expression (extrusion) of Ca2 in reticulum associated with hypoxia
8) Confidence 0.36 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.78 Pain Relevance 0.10
Anoxia (3 min) reduced this SERCA-mediated Ca2+ clearance to 6.2 nM/s or ?
Negative_regulation (this) of Gene_expression (clearance) of Ca2 associated with hypoxia
9) Confidence 0.36 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.60 Pain Relevance 0
In many heart failure models, decreased SR Ca2+ load [33,34] due to reduced expression of SERCA protein [11,33] or impaired SERCA regulation by phospholamban [35,36] are responsible, at least in part, for the E-C uncoupling.
Negative_regulation (reduced) of Gene_expression (expression) of Ca2 in heart associated with myocardial infarction
10) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.61 Pain Relevance 0.03
In many heart failure models, decreased SR Ca2+ load [33,34] due to reduced expression of SERCA protein [11,33] or impaired SERCA regulation by phospholamban [35,36] are responsible, at least in part, for the E-C uncoupling.
Negative_regulation (decreased) of Gene_expression (expression) of Ca2 in heart associated with myocardial infarction
11) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.62 Pain Relevance 0.06
Ca2+ transients were reduced to 9?
Negative_regulation (reduced) of Gene_expression (transients) of Ca2
12) Confidence 0.35 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.30 Pain Relevance 0
Acid-evoked Ca2+ transients were, however, completely blocked by 500 ?
Negative_regulation (evoked) of Gene_expression (transients) of Ca2
13) Confidence 0.35 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.15 Pain Relevance 0.14
M) and AMG 9810 also inhibited Ca2+ transients evoked by aaa pHo 6.2 (Fig. 16a, b, d).
Negative_regulation (inhibited) of Gene_expression (transients) of Ca2
14) Confidence 0.35 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.34 Pain Relevance 0
A Ca2+ transient was only considered to have occurred where this ?
Negative_regulation (occurred) of Gene_expression (transient) of Ca2
15) Confidence 0.35 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.58 Pain Relevance 0
Given the prominent role for mitochondria in Ca2+ buffering in these cells [2, 63, 79, 83, 103], one might also anticipate that reduced mitochondrial Ca2+ uptake should contribute to the enhanced Ca2+ transient.
Negative_regulation (reduced) of Gene_expression (uptake) of Ca2
16) Confidence 0.35 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.79 Pain Relevance 0.19
Acid-evoked Ca2+ transients were, however, completely blocked by 500 ?
Negative_regulation (blocked) of Gene_expression (transients) of Ca2
17) Confidence 0.35 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.15 Pain Relevance 0.14
The inhibition of Ca2+ channel currents produced by 10 microM 5HT occurred in two phases, an initial slowing of current activation rate (kinetic slowing), which was complete within 10 s, and a simultaneous reduction in steady state current amplitude (steady state inhibition), which peaked in approximately 1 min.
Negative_regulation (inhibition) of Gene_expression (produced) of Ca2 associated with 5ht
18) Confidence 0.33 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9212275 Disease Relevance 0.49 Pain Relevance 0.59
In thiopental-treated cardiomyocytes, there was a decrease in expression of the proapoptotic protein Bax, caspase-3 activation, and intracellular Ca2+ content.
Negative_regulation (decrease) of Gene_expression (expression) of Ca2 in cardiomyocytes
19) Confidence 0.25 Published 2010 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2824862 Disease Relevance 0.75 Pain Relevance 0
Therefore, polyamines seem to inhibit Ca2+ conductance through VDCC, hence inhibiting contractions of GI tract.
Negative_regulation (inhibit) of Gene_expression (conductance) of Ca2
20) Confidence 0.20 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0.03

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