INT70262

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Context Info
Confidence 0.66
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.64
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth)
Anatomy Link Frequency
parathyroid 4
skeleton 1
urine 1
Pth (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 1 99.24 Very High Very High Very High
Pain 5 71.52 Quite High
palliative 3 41.36 Quite Low
iatrogenic 1 36.28 Quite Low
carpal tunnel syndrome 1 15.84 Low Low
Sciatica 1 8.96 Low Low
spinal stenosis 1 7.60 Low Low
fibrosis 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 22 99.48 Very High Very High Very High
Stress Fractures 106 98.72 Very High Very High Very High
Rickets 21 90.40 High High
Osteoporosis 12 89.60 High High
Breast Cancer 8 84.16 Quite High
Frailty 7 83.00 Quite High
Targeted Disruption 7 81.04 Quite High
Cancer 14 80.80 Quite High
Metastasis 4 80.44 Quite High
Muscle Weakness 4 79.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On day 0, mice receiving Low-Ca had increased serum parathyroid hormone (PTH) and tartrate-resistant acid phosphatase 5b levels, indicating secondary hyperparathyroidism and high bone turnover, which was maintained until day 17.
Gene_expression (levels) of PTH in parathyroid associated with hypercalcemia
1) Confidence 0.66 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17909065 Disease Relevance 1.32 Pain Relevance 0
On day 0, mice receiving Low-Ca had increased serum parathyroid hormone (PTH) and tartrate-resistant acid phosphatase 5b levels, indicating secondary hyperparathyroidism and high bone turnover, which was maintained until day 17.
Gene_expression (levels) of parathyroid hormone in parathyroid associated with hypercalcemia
2) Confidence 0.66 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17909065 Disease Relevance 1.33 Pain Relevance 0
In mild vitamin D deficiency, the elevation of serum PTH increases the conversion of 25(OH)D to 1,25(OH)D to compensate for the insufficient 25(OH)D available; however, elevation in PTH increases bone resorption, leading to additional bone loss [19].
Gene_expression (elevation) of serum PTH associated with hypercalcemia
3) Confidence 0.50 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.97 Pain Relevance 0.07
0.002) serum calcium concentration prior to calcium supplement ingestion, a 16.5% lower serum PTH concentration, and a 65% greater increase in calcium absorption fraction.


Gene_expression (concentration) of serum PTH
4) Confidence 0.50 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.22 Pain Relevance 0
We found that by keeping the cells in culture 2 weeks after the withdrawal of Activin A, the cells were able to produce PTH.
Gene_expression (produce) of PTH associated with withdrawal
5) Confidence 0.47 Published 2009 Journal Stem Cells Dev. Section Abstract Doc Link 19025488 Disease Relevance 0 Pain Relevance 0.05
In primary culture of neonatal mouse renal tubules, in which 1,25-(OH)2D3 was produced from 25-OHD3 in response to PTH, SFO significantly inhibited PTH-induced production of 1,25-(OH)2D3 at 30 mumol/L, which is attainable in the urine of patients receiving a therapeutic intravenous dose of SFO.
Gene_expression (production) of PTH-induced in urine
6) Confidence 0.44 Published 1997 Journal Bone Section Abstract Doc Link 9213008 Disease Relevance 0.32 Pain Relevance 0
CTR and VDR are both involved in sustaining normocalcemia by inhibiting the production of parathyroid hormone [36].
Gene_expression (production) of parathyroid hormone in parathyroid
7) Confidence 0.20 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.48 Pain Relevance 0
The observed interaction between a CTR minor allele and the VDR C-A haplotype and their association with stress fractures may be explained by the inhibitory effect of these proteins on parathyroid hormone production.
Gene_expression (production) of parathyroid hormone in parathyroid associated with stress fractures
8) Confidence 0.20 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.45 Pain Relevance 0
Also, studies find the increases in bone formation induced by antisclerostin antibody, unlike PTH, not associated with increases in bone resorption in the aged rodent skeleton.
Gene_expression (antibody) of PTH in skeleton associated with hypercalcemia
9) Confidence 0.20 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.56 Pain Relevance 0

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