INT70263

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Context Info
Confidence 0.05
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp39a1) endoplasmic reticulum (Cyp39a1) lipid metabolic process (Cyp39a1)
Anatomy Link Frequency
renal tubule 1
proximal 1
Cyp39a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 25.00 Low Low
Somatostatin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 78 98.44 Very High Very High Very High
Hypophosphatemia 12 89.16 High High
Kidney Stones 5 72.32 Quite High
Disease 10 50.44 Quite High
Cirrhosis 1 32.28 Quite Low
Hypercalcemia 3 31.52 Quite Low
Hypertension 1 30.60 Quite Low
Syndrome 4 25.24 Quite Low
Nevus 1 24.48 Low Low
Neurocutaneous Syndromes 1 23.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated concentrations of FGF23 internalise and reduce the NaPi-IIa and c cotransporters in the proximal renal tubule, reducing Pi reabsorption and suppressing 1 alpha-hydroxylase activity, thus, reducing 1,25-(OH)2D and serum Pi concentrations (Fig. 2) [11].
Negative_regulation (suppressing) of alpha-hydroxylase in renal tubule
1) Confidence 0.05 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.79 Pain Relevance 0
These in vitro findings together with the clinical observations suggest that SFO, after filtration through the glomerulus and reabsorption in the proximal renal tubules, impaired proximal renal tubular function, such as tubular reabsorption of phosphate and 1 alpha-hydroxylase activity, leading to hypophosphatemic osteomalacia.
Negative_regulation (impaired) of alpha-hydroxylase in proximal associated with rickets
2) Confidence 0.04 Published 1997 Journal Bone Section Abstract Doc Link 9213008 Disease Relevance 0.17 Pain Relevance 0

General Comments

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