INT7027

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.20
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn)
Anatomy Link Frequency
neuronal 2
caudate putamen 2
lobes 2
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 10 99.68 Very High Very High Very High
dopamine receptor 3 99.42 Very High Very High Very High
Dopamine 116 97.16 Very High Very High Very High
Endogenous opioid 1 91.36 High High
Kappa opioid receptor 1 87.12 High High
Dynorphin 7 77.92 Quite High
Nucleus accumbens 3 53.84 Quite High
amygdala 1 49.68 Quite Low
Hippocampus 2 48.88 Quite Low
Enkephalin 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypertrophy 3 85.12 High High
Cancer 7 64.72 Quite High
Urological Neuroanatomy 1 50.96 Quite High
Apoptosis 10 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Macrocephaly 2 5.00 Very Low Very Low Very Low
Glioblastoma 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Striatal dopamine receptor D1 (DRD1) and prodynorphin (PDyn) mRNA levels were significantly elevated in KO animals, suggesting an enhancement in neuronal activity associated with the striatonigral projection pathway, while dopamine receptor D2 (DRD2) and preproenkephalin (PPE) mRNA levels remained unchanged.
Positive_regulation (elevated) of Transcription (levels) of PDyn in neuronal associated with dopamine receptor
1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.44
Ovarian pro-DYN mRNA levels were significantly elevated in PMSG-primed immature rats 12-24 h after receiving an ovulatory dose of hCG.
Positive_regulation (elevated) of Transcription (levels) of pro-DYN
2) Confidence 0.02 Published 1992 Journal Mol. Endocrinol. Section Abstract Doc Link 1337148 Disease Relevance 0 Pain Relevance 0
ProDyn mRNA levels were up-regulated by 3- to 4-fold in the intermediate lobes of postpartum females as compared to pregnant or nonpregnant female rats, whereas POMC mRNA levels were unchanged, suggesting a role for intermediate lobe ProDyn in the postpartum period of the female rat.
Positive_regulation (up-regulated) of Transcription (levels) of ProDyn in lobes
3) Confidence 0.02 Published 1993 Journal Endocrinology Section Abstract Doc Link 8243288 Disease Relevance 0 Pain Relevance 0.08
Previous studies in our laboratory showed that "binge" pattern cocaine administration increases preprodynorphin (ppDyn) mRNA levels in the caudate putamen and circulating levels of corticosterone in the rat.
Positive_regulation (increases) of Transcription (levels) of ppDyn in caudate putamen associated with cocaine
4) Confidence 0.00 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11427339 Disease Relevance 0.05 Pain Relevance 0.37

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox