INT70273

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 7.85
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CALB2)
Anatomy Link Frequency
putamen 1
lung 1
CALB2 (Homo sapiens)
CALB2 - D28K (1)
Pain Link Frequency Relevance Heat
Enkephalin 10 99.76 Very High Very High Very High
Calcitonin gene-related peptide 7 99.72 Very High Very High Very High
Limbic system 1 99.72 Very High Very High Very High
substance P 15 99.28 Very High Very High Very High
Neuropeptide 4 98.12 Very High Very High Very High
Thalamus 2 91.96 High High
Serotonin 1 91.56 High High
Dorsal column 1 91.08 High High
Angina 14 88.48 High High
medulla 7 86.36 High High
Disease Link Frequency Relevance Heat
Mesothelioma 206 99.94 Very High Very High Very High
Skin Cancer 6 99.88 Very High Very High Very High
Cancer 54 98.86 Very High Very High Very High
Pleural Solitary Fibrous Tumor 5 98.56 Very High Very High Very High
Adenocarcinoma 2 98.04 Very High Very High Very High
Malignant Neoplastic Disease 85 96.12 Very High Very High Very High
Lung Cancer 14 95.72 Very High Very High Very High
Carcinoma 8 95.68 Very High Very High Very High
Necrosis 2 93.16 High High
Hyperplasia 1 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The organization of the cholinergic fiber system was compared with that of striatal systems expressing immunoreactivity for calbindin D28k, met-enkephalin, substance P, tyrosine hydroxylase, and parvalbumin.
Gene_expression (expressing) of calbindin D28k associated with enkephalin and substance p
1) Confidence 0.75 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9214537 Disease Relevance 0 Pain Relevance 0.30
Thus, the calcium-binding protein calbindin D28K is found in cells that are located in three ­layers of the mammalian SC [3, 23, 29, 31, 44].
Gene_expression (found) of calbindin D28K (D28K)
2) Confidence 0.58 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1698867 Disease Relevance 0 Pain Relevance 0.07
In the present study, we carried out histochemical and immunohistochemical procedures in the Pa of normal individuals to visualize the pattern of distribution of acetylcholinesterase (AChE), calbindin D-28k (CB), parvalbumin (PV), calretinin (CR), limbic system-associated membrane protein (LAMP), substance P (SP), and enkephalin (ENK).
Gene_expression (distribution) of calretinin associated with enkephalin, limbic system and substance p
3) Confidence 0.56 Published 2004 Journal Synapse Section Abstract Doc Link 14666515 Disease Relevance 0 Pain Relevance 0.39
On immunohistochemistry, tumor cells showed diffuse positivity with vimentin, CD34 and BCL2 along with cytoplasmic positivity for MIC2 (CD99), whereas cytokeratin, EMA, calretinin and HBME-1 were negative.
Neg (negative) Gene_expression (negative) of calretinin associated with cancer
4) Confidence 0.48 Published 2010 Journal Indian J Pathol Microbiol Section Abstract Doc Link 20699522 Disease Relevance 1.30 Pain Relevance 0.07
Histological findings of specimens obtained from a percutaneous biopsy revealed spindle tumor cells, and the immunohistochemistry showed that the tumor cells were positive for CK-7, AE1/AE3, and vimentin and negative for calretinin, D2-40, and WT-1.
Neg (negative) Gene_expression (negative) of calretinin associated with cancer
5) Confidence 0.48 Published 2010 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 20163019 Disease Relevance 1.30 Pain Relevance 0.09
Using indirect immunohistochemistry, we analyzed the distribution of calretinin (CR), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), substance P (SP), neurokinin A (NKA), vasoactive intestinal peptide (VIP), nitric oxide synthase (NOS), tyrosine hydroxylase (TH), histamine, serotonin, enkephalin, and, enzyme histochemically, NADPH-diaphorase (NADPH-d).
Spec (analyzed) Gene_expression (distribution) of calretinin associated with neuropeptide, enkephalin, serotonin, substance p and calcitonin gene-related peptide
6) Confidence 0.44 Published 1997 Journal Acta Histochem. Section Abstract Doc Link 9381913 Disease Relevance 0 Pain Relevance 0.55
Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma.
Gene_expression (positive) of Calretinin associated with malignant neoplastic disease and lung cancer
7) Confidence 0.40 Published 2009 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 19346724 Disease Relevance 0.58 Pain Relevance 0.08
Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma.
Gene_expression (/) of Calretinin associated with malignant neoplastic disease and lung cancer
8) Confidence 0.40 Published 2009 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 19346724 Disease Relevance 0.58 Pain Relevance 0.08
However, according to a recent review article, mesothelin is positive in 27% of squamous cell carcinomas, and calretinin and cytokeratin 5/6 can be raised in both squamous cell carcinoma of the lung and adenocarcinoma of both the lung and other sites [37].
Gene_expression (raised) of calretinin in lung associated with adenocarcinoma and skin cancer
9) Confidence 0.30 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2652430 Disease Relevance 1.84 Pain Relevance 0.03
The most specific and sensitive markers for mesothelioma are mesothelin (in epithelioid mesothelioma), calretinin and cytokeratin 5/6.
Gene_expression (/) of calretinin associated with mesothelioma
10) Confidence 0.30 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2652430 Disease Relevance 1.74 Pain Relevance 0.04
The large cell neurons in the putamen were preferentially reduced, the immunoreactivity for tyrosine hydroxylase reflecting the dopaminergic afferent and efferent pathways was severely affected, and the expression of 3 calcium binding proteins (i.e. parvalbumin, calbindin-D28K, and calretinin) was disturbed in various ways.
Gene_expression (expression) of calretinin in putamen
11) Confidence 0.07 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 15535132 Disease Relevance 0.50 Pain Relevance 0.83

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