INT7028

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Context Info
Confidence 0.81
First Reported 1984
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 90
Total Number 94
Disease Relevance 8.89
Pain Relevance 73.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn)
Anatomy Link Frequency
spinal 7
neurons 6
spinal cord 5
tail 3
hypothalamus 3
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 602 100.00 Very High Very High Very High
Enkephalin 182 100.00 Very High Very High Very High
Analgesic 155 100.00 Very High Very High Very High
substance P 105 100.00 Very High Very High Very High
Glutamate 63 100.00 Very High Very High Very High
noradrenaline 31 100.00 Very High Very High Very High
Neuropeptide 30 100.00 Very High Very High Very High
Catecholamine 6 100.00 Very High Very High Very High
Opioid 514 99.96 Very High Very High Very High
Morphine 184 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 50 100.00 Very High Very High Very High
Aids-related Complex 4 99.76 Very High Very High Very High
Vibrio Infection 12 99.72 Very High Very High Very High
Targeted Disruption 50 99.38 Very High Very High Very High
Pain 149 98.56 Very High Very High Very High
INFLAMMATION 214 98.52 Very High Very High Very High
Inflammatory Pain 29 97.16 Very High Very High Very High
Anxiety Disorder 92 96.92 Very High Very High Very High
Ganglion Cysts 39 95.48 Very High Very High Very High
Stress 146 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine given intracerebroventricularly releases spinal dynorphin A (Dyn) in mice.
Localization (releases) of dynorphin in spinal associated with dynorphin and morphine
1) Confidence 0.81 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 7902680 Disease Relevance 0 Pain Relevance 0.94
Morphine given intracerebroventricularly releases spinal dynorphin A (Dyn) in mice.
Localization (releases) of Dyn in spinal associated with dynorphin and morphine
2) Confidence 0.81 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 7902680 Disease Relevance 0 Pain Relevance 0.94
DynorphinA (Dyn) administered intrathecally or released spinally in mice produces antianalgesia, that is, antagonizes morphine analgesia (tail-flick test).
Localization (released) of DynorphinA in tail associated with tail-flick, analgesia and morphine
3) Confidence 0.81 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9610949 Disease Relevance 0 Pain Relevance 0.74
Thus, Dyn, given intrathecally or released spinally, activates a pathway that is inhibited by intracerebroventricular flumazenil.
Localization (released) of Dyn associated with intracerebroventricular
4) Confidence 0.81 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9610949 Disease Relevance 0 Pain Relevance 1.07
DynorphinA (Dyn) administered intrathecally or released spinally in mice produces antianalgesia, that is, antagonizes morphine analgesia (tail-flick test).
Localization (released) of Dyn in tail associated with tail-flick, analgesia and morphine
5) Confidence 0.81 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9610949 Disease Relevance 0 Pain Relevance 0.74
Immunohistochemical techniques were used to localize dynorphin B and methionine-enkephalin in the mouse hippocampus.
Localization (localize) of dynorphin B in hippocampus associated with dynorphin, hippocampus and enkephalin
6) Confidence 0.80 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2566141 Disease Relevance 0.07 Pain Relevance 0.48
The unique specificity of monoclonal antibody 17.M should make it useful in investigations of the differential localization and release of Dyn A and Dyn B and the precursor D32.
Localization (release) of Dyn
7) Confidence 0.80 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860615 Disease Relevance 0 Pain Relevance 0.30
The unique specificity of monoclonal antibody 17.M should make it useful in investigations of the differential localization and release of Dyn A and Dyn B and the precursor D32.
Localization (release) of Dyn
8) Confidence 0.80 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860615 Disease Relevance 0 Pain Relevance 0.30
Dyn release reflected activation of descending pathways in the thoracic spinal cord, because vagal afferent stimulation still increased the release of Dyn after bilateral dorsal rhizotomy of T(2)-T(5).
Localization (release) of Dyn in thoracic associated with dorsal rhizotomy, dynorphin and spinal cord
9) Confidence 0.78 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15297264 Disease Relevance 0.36 Pain Relevance 1.27
Localization of dynorphin gene product-immunoreactivity in neurons from spinal cord and dorsal root ganglia.
Localization (Localization) of dynorphin gene in neurons associated with dynorphin and spinal cord
10) Confidence 0.75 Published 1986 Journal Neuroscience Section Title Doc Link 2876400 Disease Relevance 0.17 Pain Relevance 0.70
Opioid peptides derived from the precursor, prodynorphin, are co-localized with vasopressin in the hypothalamus and posterior pituitary, and vasopressin and prodynorphin synthesis are coordinately regulated during salt-loading.
Localization (co-localized) of prodynorphin in posterior pituitary associated with opioid
11) Confidence 0.74 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255170 Disease Relevance 0 Pain Relevance 0.10
Thus, PC2 appears to be involved in monobasic processing, leading to the generation of Dyn A-8, Dyn A-17, and Dyn B-13 from prodynorphin under physiological conditions.
Localization (generation) of prodynorphin associated with dynorphin
12) Confidence 0.73 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.53
Previously, a number of analgesic agonists, when administered i.c.v. to mice, were shown putatively to activate the release of dynorphin A (1-17) (Dyn A) in the spinal cord.
Localization (release) of Dyn in spinal cord associated with dynorphin, analgesic, agonist and spinal cord
13) Confidence 0.72 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1348537 Disease Relevance 0 Pain Relevance 0.93
There are only a few studies suggesting that CRF-R activation can directly evoke dynorphin release, and these reports established the potential for these two systems to interact in vivo [1], [40], [41].
Localization (release) of dynorphin associated with dynorphin
14) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.97 Pain Relevance 0.64
The anxiogenic-like effects of CRF and stressin 1 suggest that CRF1-R receptor activation induces dynorphin release in the basolateral amygdala (BLA), a brain region regarded as necessary for anxiety-like behaviors [36].
Localization (release) of dynorphin in BLA associated with dynorphin, anxiety disorder and amygdala
15) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.37 Pain Relevance 0.71
The antagonistic action of midazolam against morphine-induced antinociception involved the release of Dyn in the spinal cord, as evidenced by the following results. 1) Administration of naloxone, nor-binaltorphimine and dynorphin antiserum, IT, eliminated the antagonistic effect of midazolam, given ICV, against morphine.
Localization (release) of Dyn in spinal cord associated with antinociception, dynorphin, versed, narcan, spinal cord and morphine
16) Confidence 0.71 Published 1993 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7903457 Disease Relevance 0 Pain Relevance 1.85
The unique specificity of monoclonal antibody 17.M should make it useful in investigations of the differential localization and release of Dyn A and Dyn B and the precursor D32.
Localization (localization) of Dyn
17) Confidence 0.70 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860615 Disease Relevance 0 Pain Relevance 0.30
The unique specificity of monoclonal antibody 17.M should make it useful in investigations of the differential localization and release of Dyn A and Dyn B and the precursor D32.
Localization (localization) of Dyn
18) Confidence 0.70 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860615 Disease Relevance 0 Pain Relevance 0.30
Since the up-regulation of DynA in the dorsal horn persisted and paralleled the increase in c-Fos-positive cells, the release of DynA may be associated with spontaneous pain in our model.
Localization (release) of DynA in dorsal horn associated with pain, spontaneous pain and dorsal horn
19) Confidence 0.69 Published 2005 Journal Pain Section Abstract Doc Link 15733648 Disease Relevance 0.51 Pain Relevance 0.73
Left vagal stimulation increased Dyn release, inhibited basal SP release, and blunted the coronary artery occlusion-induced release of SP.
Localization (release) of Dyn in coronary artery associated with dynorphin and substance p
20) Confidence 0.68 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15297264 Disease Relevance 0.38 Pain Relevance 1.26

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