INT70283

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 9.64
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1)
embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)
Anatomy Link Frequency
endothelial cells 2
pancreas 2
neuronal 1
BxPC-3 1
oligodendrocyte 1
Racgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 175 98.60 Very High Very High Very High
agonist 4 97.72 Very High Very High Very High
withdrawal 42 96.52 Very High Very High Very High
Delta opioid receptors 10 96.40 Very High Very High Very High
Morphine 3 94.20 High High
Inflammation 94 89.52 High High
Opioid 2 88.12 High High
Spinal cord 396 83.72 Quite High
Kinase C 1 81.72 Quite High
Hippocampus 83 75.68 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 107 100.00 Very High Very High Very High
Inflammatory Breast Neoplasms 460 99.40 Very High Very High Very High
Cancer 432 99.32 Very High Very High Very High
Disease 155 98.98 Very High Very High Very High
Metastasis 86 98.90 Very High Very High Very High
Cv Unclassified Under Development 65 98.60 Very High Very High Very High
Pancreatic Cancer 14 97.60 Very High Very High Very High
Death 121 97.24 Very High Very High Very High
Urological Neuroanatomy 4 97.04 Very High Very High Very High
Cognitive Disorder 37 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At delta1 receptors, DPDPE fully expressed its activation of GTPase.
Gene_expression (expressed) of GTPase
1) Confidence 0.44 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9215703 Disease Relevance 0.29 Pain Relevance 1.13
Specifically, dynamin GTPase domain mutations that inhibit endocytosis when expressed in COS-7 cells have a reticular type of localization as opposed to the more diffuse cytoplasmic localization of wildtype dynamin [34].
Gene_expression (expressed) of GTPase
2) Confidence 0.12 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0 Pain Relevance 0
There are several isoforms of the Rac GTPase, with Rac1 being the predominant isoform in macrophages and monocytic cells while Rac2 is predominantly expressed in neutrophils [44].
Gene_expression (expressed) of GTPase in neutrophils
3) Confidence 0.11 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.05 Pain Relevance 0.07
These include neurosteroids and cholesterol-binding agents, which have been shown to delay the progression of disease in animal models of NP-C.23–25 Direct or indirect overexpression of the GTPase, Rab 9, has been shown to reverse the NP-C phenotype in tissue culture26,27 and reduce stored lipids and prolong lifespan in a mouse model of NP-C.28 Recently, curcumin has been suggested to have beneficial effects on intracellular calcium homeostasis and lipid metabolism in NPC1-mutant mice.29 However, data from clinical studies are required to assess the possible role of these compounds in NP-C therapy.
Gene_expression (overexpression) of GTPase associated with lifespan and disease
4) Confidence 0.08 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2781062 Disease Relevance 0.74 Pain Relevance 0.04
These investigators showed that a dominant negative mutant of N-Ras (a small GTPase from a different family to that of Rac1) suppressed capillary-network formation of endothelial cells induced by VEGF-A-producing fibroblasts whereas the mutants of Rac1, RhoA or Cdc42 did not.
Gene_expression (producing) of GTPase in endothelial cells
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.20 Pain Relevance 0.07
The purpose of the current study was to examine the regulatory and functional role of the Rho GTPase, Rac1 in NADPH oxidase activation, ROS generation and neuronal cell death/cognitive dysfunction following global cerebral ischemia in the male rat.


Spec (examine) Gene_expression (role) of GTPase in neuronal associated with cognitive disorder, cv general 4 under development, ischemia and death
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935374 Disease Relevance 0.72 Pain Relevance 0.20
Functional outcome of Rac GTPase inhibition on learning and spatial memory in the hippocampal CA1 region
Gene_expression (inhibition) of Rac GTPase
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.07 Pain Relevance 0.30
The putative oncogene, RhoC GTPase, was found to be over-expressed in 90% of the IBC tumors analyzed, compared with 38% of the non-IBC specimens.
Gene_expression (expressed) of GTPase associated with inflammatory breast neoplasms and cancer
8) Confidence 0.05 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.46 Pain Relevance 0.04
Transfection and over-expression of RhoC GTPase in Epstein-Barr virus-immortalized HME cells produce highly motile and invasive tumorigenic clones (van Golen et al, unpublished data).
Gene_expression (expression) of GTPase
9) Confidence 0.05 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.04 Pain Relevance 0.03
These data, combined with the observation that over-expression of RhoC GTPase correlates with tumor progression in aggressive ductal adenocarcinoma of the pancreas [40], suggest that RhoC is a key element in the IBC metastatic phenotype.
Gene_expression (over) of GTPase in pancreas associated with inflammatory breast neoplasms, adenocarcinoma and cancer
10) Confidence 0.05 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 0.80 Pain Relevance 0
These data, combined with the observation that over-expression of RhoC GTPase correlates with tumor progression in aggressive ductal adenocarcinoma of the pancreas [40], suggest that RhoC is a key element in the IBC metastatic phenotype.
Gene_expression (expression) of GTPase in pancreas associated with inflammatory breast neoplasms, adenocarcinoma and cancer
11) Confidence 0.04 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 0.80 Pain Relevance 0
As shown in Figure 2A RhoC GTPase is expressed on the protein level to varying degrees in the panel of 10 pancreatic cancer cell lines that were analyzed for cav-1 expression.
Gene_expression (expressed) of GTPase associated with pancreatic cancer
12) Confidence 0.02 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.46 Pain Relevance 0
Comparison of the BxPC-3 (derived from a primary tumor) and HPAF-II (derived from a metastasis) demonstrates a reciprocal relationship between cav-1 expression and p42/p44 Erk activation with PC cell migration, invasion, RhoC GTPase and p38 MAPK activation.
Gene_expression (expression) of GTPase in BxPC-3 associated with adenocarcinoma, cancer and metastasis
13) Confidence 0.02 Published 2005 Journal Mol Cancer Section Abstract Doc Link PMC1173138 Disease Relevance 1.19 Pain Relevance 0
Qualitatively transplanted cells expressing different Rho GTPase mutants showed similar migratory profiles with their peak at the injection sites (Figure 5C-F).
Gene_expression (expressing) of GTPase
14) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0 Pain Relevance 0.07
A double-label immunofluorescence study with anti-GFP and anti-RIP (an oligodendrocyte marker) confirmed this trend in both control cells and cells expressing Rho GTPase mutants.
Gene_expression (expressing) of GTPase in oligodendrocyte
15) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0 Pain Relevance 0.03
Proliferation of NSPCs in the presence of bFGF also did not show prominent change by expressing Rho GTPase mutants.
Gene_expression (expressing) of GTPase
16) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.27 Pain Relevance 0.12
We also plotted the profile of cell numbers along the rostrocaudal axis for cells expressing different Rho GTPase mutants.
Gene_expression (expressing) of GTPase
17) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0 Pain Relevance 0.07
We observed an unaltered differentiation phenotype of NSPCs expressing Rho GTPase mutants after transplantation and also after induction of in vitro differentiation by growth factor withdrawal.
Gene_expression (expressing) of GTPase associated with withdrawal
18) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.30 Pain Relevance 0.08
Microscopic evaluation on the distribution of transplanted cells revealed a similar pattern both in sagittal and coronal planes irrespective of the expressing Rho GTPase mutants except for RhoCA, which eliminated all the NSPCs 7 days after transplantation.
Gene_expression (expressing) of GTPase
19) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0 Pain Relevance 0.08
The fact that the expression of Rho GTPase induces clustering of CD44 and MMP-9 in the advancing lamellipodia of endothelial cells [33] prompted us to determine the effects BP on the localization of CD44 and MMP-9 in the indicated PC3 cell lines.
Gene_expression (expression) of GTPase in endothelial cells
20) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.24 Pain Relevance 0

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