INT70286

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.78
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1)
embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)
Anatomy Link Frequency
neuronal 2
hippocampus CA1 2
Racgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 344 99.88 Very High Very High Very High
Opioid 2 99.68 Very High Very High Very High
Hippocampus 68 98.60 Very High Very High Very High
Intracerebroventricular 8 98.36 Very High Very High Very High
Delta opioid receptors 10 97.56 Very High Very High Very High
Morphine 3 95.48 Very High Very High Very High
agonist 3 91.80 High High
Enkephalin 3 89.84 High High
Periaqueductal grey 2 75.24 Quite High
anesthesia 16 33.92 Quite Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 24 99.92 Very High Very High Very High
Cv General 4 Under Development 220 99.88 Very High Very High Very High
Stress 104 99.44 Very High Very High Very High
Cv Unclassified Under Development 120 99.16 Very High Very High Very High
Death 76 98.12 Very High Very High Very High
Injury 12 81.00 Quite High
Urological Neuroanatomy 4 75.72 Quite High
Apoptosis 24 61.28 Quite High
Cognitive Disorder 48 50.00 Quite Low
Brain Hemorrhage 4 32.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The blockade of G(i2)alpha subunits by specific antibodies impaired the activation of G alpha-related GTPase by all opioids.
Negative_regulation (impaired) of Positive_regulation (activation) of GTPase associated with opioid
1) Confidence 0.43 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9215703 Disease Relevance 0.30 Pain Relevance 1.20
Inhibition of Rac GTPase activation markedly decreased oxidative neuronal damage to hippocampal CA1 region lipids, proteins, and DNA following ischemia/reperfusion injury.
Negative_regulation (Inhibition) of Positive_regulation (activation) of Rac GTPase in neuronal associated with reperfusion injury and ischemia
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.47 Pain Relevance 0.36
Inhibition of Rac GTPase activation attenuates induction of oxidative stress damage in the hippocampus CA1 after GCI
Negative_regulation (Inhibition) of Positive_regulation (induction) of Rac GTPase in hippocampus CA1 associated with stress, ischemia and hippocampus
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.29 Pain Relevance 0.45
production in the hippocampal CA1 region following GCI by determining the effect of inhibiting Rac GTPase activation via administration of NSC23766.
Negative_regulation (inhibiting) of Positive_regulation (activation) of Rac GTPase associated with ischemia
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.55 Pain Relevance 0.28
The 50 µg dose of the inhibitor was chosen based on a previous dose response curve performed in our lab which showed it to be the most optimal and effective dose in inhibiting Rac GTPase activation in the hippocampal CA1 region following intracerebroventricular (icv) injection, and which did not display any significant behavioral side effects [7].
Negative_regulation (inhibiting) of Positive_regulation (activation) of Rac GTPase associated with intracerebroventricular
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.17 Pain Relevance 0.13

General Comments

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