INT7029

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Context Info
Confidence 0.61
First Reported 1983
Last Reported 2009
Negated 18
Speculated 11
Reported most in Abstract
Documents 51
Total Number 62
Disease Relevance 12.89
Pain Relevance 40.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn)
Anatomy Link Frequency
striatum 4
spinal 3
hypothalamus 3
brain structures 2
ventral 2
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 300 100.00 Very High Very High Very High
Enkephalin 95 100.00 Very High Very High Very High
Opioid 80 100.00 Very High Very High Very High
Spinal cord 30 100.00 Very High Very High Very High
intrathecal 8 100.00 Very High Very High Very High
Nicotine 24 99.98 Very High Very High Very High
Calcitonin gene-related peptide 10 99.92 Very High Very High Very High
antagonist 27 99.90 Very High Very High Very High
Kappa opioid receptor 13 99.84 Very High Very High Very High
Intracerebroventricular 7 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 15 100.00 Very High Very High Very High
Hyperalgesia 14 99.76 Very High Very High Very High
Ganglion Cysts 45 99.34 Very High Very High Very High
Nervous System Injury 4 98.96 Very High Very High Very High
INFLAMMATION 18 98.88 Very High Very High Very High
Nociception 13 98.72 Very High Very High Very High
Urological Neuroanatomy 11 98.72 Very High Very High Very High
Alzheimer's Dementia 8 98.36 Very High Very High Very High
Pain 4 98.28 Very High Very High Very High
Injury 8 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We had previously found that chronic ethanol ingestion resulted in decreased levels of hypothalamic and extrahypothalamic vasopressin mRNA, and the current study investigated the effect of ethanol ingestion on prodynorphin mRNA levels.
Spec (investigated) Regulation (effect) of prodynorphin
1) Confidence 0.61 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255170 Disease Relevance 0 Pain Relevance 0.08
These results indicate that hypothalamic vasopressin and prodynorphin mRNA can be differentially regulated in certain situations.
Regulation (regulated) of prodynorphin
2) Confidence 0.61 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255170 Disease Relevance 0 Pain Relevance 0
Prodynorphin and vasopressin mRNA levels are differentially affected by chronic ethanol ingestion in the mouse.
Regulation (affected) of Prodynorphin associated with enkephalin
3) Confidence 0.61 Published 1993 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8255170 Disease Relevance 0 Pain Relevance 0.20
As shown by an in situ hybridization, a single dose of morphine had no significant effect on the PDYN, PENK and D2 mRNA levels in the nucleus accumbens and striatum.
Neg (no) Regulation (effect) of PDYN in nucleus accumbens associated with nucleus accumbens and morphine
4) Confidence 0.60 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574833 Disease Relevance 0 Pain Relevance 0.87
Effects of big dynorphin (Big Dyn), a prodynorphin-derived peptide consisting of dynorphin A (Dyn A) and dynorphin B (Dyn B) on memory function, anxiety, and locomotor activity were studied in mice and compared to those of Dyn A and Dyn B.
Regulation (Effects) of big dynorphin associated with dynorphin, eae and anxiety disorder
5) Confidence 0.45 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16292317 Disease Relevance 0.17 Pain Relevance 0.38
The potencies of Dyn A and Dyn A-(2-13) were not affected by preadministration of naloxone (5 mg/kg s.c.), but the motor effects of Dyn A-(1-13) (20 nmol/mouse i.c.v.) were significantly reduced by coadministration of low doses (0.2-0.6 nmol/mouse) of the N-methyl-D-aspartate (NMDA) receptor antagonists dextrorphan, MK-801 and CPP.
Neg (not) Regulation (affected) of Dyn associated with dynorphin, antagonist and narcan
6) Confidence 0.45 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353375 Disease Relevance 0 Pain Relevance 1.22
Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum.
Regulation (changes) of dynorphin in striatum associated with dynorphin, nicotine and enkephalin
7) Confidence 0.45 Published 2009 Journal Psychopharmacology (Berl.) Section Title Doc Link 18807250 Disease Relevance 0 Pain Relevance 0.58
In the present study, we examined the effect of dynorphin-(1-13) with two other dynorphin-like peptides, alpha-neoendorphin and dynorphin-(1-10) amide, on respiration.
Spec (examined) Regulation (effect) of alpha-neoendorphin associated with dynorphin
8) Confidence 0.45 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6662192 Disease Relevance 0.22 Pain Relevance 1.43
Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum.
Regulation (changes) of prodynorphin in striatum associated with dynorphin, nicotine and enkephalin
9) Confidence 0.44 Published 2009 Journal Psychopharmacology (Berl.) Section Title Doc Link 18807250 Disease Relevance 0 Pain Relevance 0.58
The effects of the opioid peptide dynorphin A (DynA) on phagocytosis in peritoneal macrophages was examined by flow cytometry (FCM).
Regulation (effects) of DynA in peritoneal macrophages associated with dynorphin and opioid
10) Confidence 0.42 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7642746 Disease Relevance 0 Pain Relevance 0.43
Results indicated that the C57BL/6 mice have a higher content of kappa-opioid binding sites and dynorphin A 1-13 in the amygdala, and dynorphin A 1-8 in the ventral tegmental area, whereas the DBA/2 mice presented a significantly higher content of kappa-opioid binding sites, prodynorphin mRNA, as well as dynorphin A 1-13 and dynorphin A 1-8 peptides in the nucleus accumbens and septum.
Regulation (content) of prodynorphin mRNA in ventral associated with nucleus accumbens, ventral tegmentum, dynorphin, amygdala and opioid
11) Confidence 0.40 Published 1997 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9394118 Disease Relevance 0.16 Pain Relevance 1.17
The effect of dynorphin A (Dyn A) and related peptides on the binding of [3H]ouabain was examined in rat cardiac sarcolemma.
Spec (examined) Regulation (effect) of Dyn associated with dynorphin
12) Confidence 0.38 Published 1996 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9011644 Disease Relevance 0 Pain Relevance 0.09
The influence of dynorphin A (DYN) and related opioid peptides on the tumoricidal function of activated murine peritoneal exudate macrophages (PEM) was investigated.
Spec (investigated) Regulation (influence) of DYN in PEM associated with dynorphin and opioid
13) Confidence 0.37 Published 1987 Journal J. Leukoc. Biol. Section Abstract Doc Link 2439627 Disease Relevance 0.07 Pain Relevance 0.26
In contrast to pro-Dyn mRNA, furin, PC1, and PC2 mRNA levels were not affected by 8-bromo-cAMP.
Neg (not) Regulation (not) of pro-Dyn mRNA
14) Confidence 0.33 Published 1995 Journal Endocrinology Section Abstract Doc Link 7867572 Disease Relevance 0.07 Pain Relevance 0.41
Radiolabeled microspheres were used to examine the effects of paralytic intrathecal doses of dynorphin A (Dyn A1-13) and Dyn A3-13 on rat brain and spinal cord blood flows and cardiac output.
Spec (examine) Regulation (effects) of Dyn in blood associated with dynorphin, spinal cord and intrathecal
15) Confidence 0.32 Published 1987 Journal Brain Res. Section Abstract Doc Link 2893653 Disease Relevance 0 Pain Relevance 0.70
The kindling was very effective in increasing the hippocampal levels of IR-DYN, alpha-neoendorphin and Leu-enkephalin, but remained without any significant effect on the levels of IR-DYN and beta-endorphin in the majority of brain structures studied.
Neg (without) Regulation (effect) of IR-DYN in brain structures associated with enkephalin
16) Confidence 0.30 Published 1983 Journal Regul. Pept. Section Abstract Doc Link 6138821 Disease Relevance 0.07 Pain Relevance 0.40
Dynorphin and prodynorphin mRNA changes in the striatum during nicotine withdrawal.
Regulation (changes) of prodynorphin in striatum associated with dynorphin, nicotine and withdrawal
17) Confidence 0.27 Published 2008 Journal Synapse Section Title Doc Link 18361441 Disease Relevance 0.27 Pain Relevance 1.04
Opioid peptides derived from the precursor, prodynorphin, are co-localized with vasopressin in the hypothalamus and posterior pituitary, and vasopressin and prodynorphin synthesis are coordinately regulated during salt-loading.
Regulation (regulated) of prodynorphin in hypothalamus associated with opioid
18) Confidence 0.27 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255170 Disease Relevance 0 Pain Relevance 0.10
The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene.
Regulation (targeted) of Pdyn associated with dynorphin, delta-9-tetrahydrocannabinol and morphine
19) Confidence 0.26 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11717384 Disease Relevance 0 Pain Relevance 0.79
The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene.
Regulation (targeted) of prodynorphin associated with dynorphin, delta-9-tetrahydrocannabinol and morphine
20) Confidence 0.26 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11717384 Disease Relevance 0 Pain Relevance 0.79

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