INT70323

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 6.55
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
colon 4
neuronal 2
cardiomyocytes 2
brain 2
reticulum 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
isoflurane 2 100.00 Very High Very High Very High
alcohol 93 99.56 Very High Very High Very High
Inflammation 96 98.24 Very High Very High Very High
depression 7 95.76 Very High Very High Very High
Prostatitis 136 94.48 High High
Glutamate receptor 1 90.56 High High
Glutamate 9 88.08 High High
Potency 3 87.48 High High
Analgesic 1 87.16 High High
anesthesia 1 84.28 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 123 99.84 Very High Very High Very High
Benign Prostatic Hypertrophy 6 99.60 Very High Very High Very High
Cancer 134 99.54 Very High Very High Very High
Disease 342 99.46 Very High Very High Very High
Aging 13 99.16 Very High Very High Very High
INFLAMMATION 105 98.24 Very High Very High Very High
Death 33 97.84 Very High Very High Very High
Stress 35 96.84 Very High Very High Very High
Drug Induced Neurotoxicity 4 95.84 Very High Very High Very High
Apoptosis 81 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hippocampal CA2 region is thought to be especially vulnerable to this ?
Negative_regulation (hippocampal) of Gene_expression (region) of CA2
1) Confidence 0.41 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 0.81 Pain Relevance 0
The hippocampal CA2 region is thought to be especially vulnerable to this ?
Negative_regulation (vulnerable) of Gene_expression (region) of CA2
2) Confidence 0.41 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 0.81 Pain Relevance 0
The purpose of this investigation was to determine in a neuronal cell which source of Ca2+ underlying the carbachol-evoked transient increase in cytoplasmic Ca2+ was reduced by isoflurane.
Negative_regulation (reduced) of Gene_expression (source) of Ca2 in neuronal associated with isoflurane
3) Confidence 0.38 Published 2003 Journal Anesthesiology Section Abstract Doc Link 14508321 Disease Relevance 0 Pain Relevance 0.30
Expression of carbonic anhydrase 2 (CA2) was found to be downregulated in colon tumors [37,38].
Negative_regulation (downregulated) of Gene_expression (Expression) of CA2 in colon associated with colon cancer
4) Confidence 0.24 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.53 Pain Relevance 0
In this study, expression of CA2 was downregulated in response to exposure to curcumin (Figure 3).
Negative_regulation (downregulated) of Gene_expression (expression) of CA2
5) Confidence 0.24 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.52 Pain Relevance 0
We further examined the expression of CFTR, CAII, IL-1?
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of CAII
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.34 Pain Relevance 0.09
We thus examined CFTR and CAII expression in human prostate hyperplasia samples with inflammation.
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of CAII associated with benign prostatic hypertrophy and inflammation
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.58 Pain Relevance 0.22
In the same study, the authors demonstrated that extracellular Ni2+, used as a blocker of Ca2+ influx, and a phosphoinositide-3-kinase inhibitor (LY294002) prevented the ?
Negative_regulation (blocker) of Gene_expression (influx) of Ca2
8) Confidence 0.22 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Tyrosine kinase inhibitors prevented the effect of indomethacin on Mac-1 expression and Ca2+ mobilization.
Negative_regulation (prevented) of Gene_expression (expression) of Ca2
9) Confidence 0.20 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
Expression of carbonic anhydrase 2 (CA2) was found to be downregulated in colon tumors [37,38].
Negative_regulation (downregulated) of Gene_expression (Expression) of carbonic anhydrase 2 in colon associated with colon cancer
10) Confidence 0.17 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.53 Pain Relevance 0
More specifically, why is the aging brain of an AD patient more sensitive to Ca2+ perturbations in general and the impact of A?
Negative_regulation (impact) of Gene_expression (perturbations) of Ca2 in brain associated with aging and disease
11) Confidence 0.13 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.58 Pain Relevance 0.13
Our previous study showed that alcohol intake significantly reduced expression of the intracellular Ca2+ cycling proteins SERCA2a, Na+-Ca2+ exchanger and phospholamban in cardiomyocytes without overt change in the SERCA2a-to-phospholamban ratio [100].
Negative_regulation (reduced) of Gene_expression (expression) of Ca2 in cardiomyocytes associated with alcohol
12) Confidence 0.12 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 0.47 Pain Relevance 0.21
Buytaert, et al. proposed that during PDT with hypericin occurs loss of the native SERCA2 protein levels and consequent endoplasmic reticulum Ca2+ depletion which causes disruption of Ca2+ homeostasis and cell death.
Negative_regulation (loss) of Gene_expression (depletion) of Ca2 in reticulum associated with cancer and death
13) Confidence 0.11 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 1.21 Pain Relevance 0
AZA groups are novel inhibitors of Ca2+ channels, SOC and non-SOC channels.
Negative_regulation (inhibitors) of Gene_expression (channels) of Ca2
14) Confidence 0.08 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525493 Disease Relevance 0.17 Pain Relevance 0.03

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