INT70326

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 15.42
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB2) plasma membrane (ITGB2) cell-cell signaling (ITGB2)
Anatomy Link Frequency
neutrophils 20
granulocytes 8
monocyte 6
respiratory 4
plasma 2
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 9 100.00 Very High Very High Very High
Migraine 7 99.18 Very High Very High Very High
cytokine 53 95.44 Very High Very High Very High
cINOD 14 93.72 High High
Angina 27 90.40 High High
Inflammation 197 88.56 High High
Inflammatory response 55 87.28 High High
psoriasis 72 81.56 Quite High
anesthesia 4 66.92 Quite High
Arthritis 9 58.76 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 1 99.62 Very High Very High Very High
Adhesions 446 99.40 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 88 99.40 Very High Very High Very High
Headache 8 99.18 Very High Very High Very High
Nicotine Addiction 734 98.34 Very High Very High Very High
Cv Unclassified Under Development 26 98.08 Very High Very High Very High
Reperfusion Injury 16 97.64 Very High Very High Very High
Carcinoma 14 96.52 Very High Very High Very High
INFLAMMATION 254 93.16 High High
Multiple Organ Failure 10 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Maximal upregulation of Mac-1 expression (40-50%) occurred after a 30-min incubation with 0.1mM indomethacin.
Positive_regulation (upregulation) of Gene_expression (expression) of Mac-1
1) Confidence 0.67 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
We found that coronary angioplasty with stent implantation produces an increase in the cell surface expression of CD11b/CD18 in neutrophils and CD38 in monocytes, following a similar time-course with a peak after 24 h, returning to basal levels after 48 h and a second peak after 7 days.
Positive_regulation (increase) of Gene_expression (expression) of CD18 in neutrophils
2) Confidence 0.67 Published 2004 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15080559 Disease Relevance 0.30 Pain Relevance 0.26
Moreover, the 22 migraine patients without aura also exhibited an increase of LFA-1 expression of T-helper cells (34.7 +/- 11.5%) compared to the 35 controls (27.5 +/- 12.0%; p < 0.01).
Positive_regulation (increase) of Gene_expression (expression) of LFA-1 in T-helper cells associated with epilepsy and migraine
3) Confidence 0.66 Published 1999 Journal Cephalalgia Section Abstract Doc Link 10570725 Disease Relevance 0.78 Pain Relevance 0.68
RESULTS: Exposure to hypoxia-reoxygenation increased neutrophil CD11b (94.33+/-40.65 vs. 34.32+/-6.83 mean channel fluorescence (MCF), P = 0.02), CD18 (109.84+/-35.44 vs. 59.05+/-6.71 MCF, P = 0.03) and endothelial ICAM-1 (146.62+/-16.78 vs. 47.29+/-9.85 MCF, P < 0.001) expression compared to normoxia.
Positive_regulation (increased) of Gene_expression (expression) of CD18 in neutrophil
4) Confidence 0.49 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15719860 Disease Relevance 0.22 Pain Relevance 0
METHODS: Isolated human neutrophil CD11b and CD18, and human umbilical vein endothelial cell (HUVEC) ICAM-1 expression and supernatant IL-1beta concentrations in response to hypoxia-reoxygenation were studied in the presence or absence of different concentrations of lidocaine (0.005, 0.05 and 0.5 mg mL(-1)).
Positive_regulation (response) of Gene_expression (expression) of CD18 in neutrophil
5) Confidence 0.49 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15719860 Disease Relevance 0.29 Pain Relevance 0
Ionomycin and thapsigargin caused a 7-10-fold increase in [Ca2+]i and a 2-4-fold increase in Mac-1 expression.
Positive_regulation (increase) of Gene_expression (expression) of Mac-1
6) Confidence 0.49 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
RESULTS: Indomethacin caused a concentration- and time-dependent upregulation of CD11b and CD18 expression and PMN adhesion to endothelial cells.
Positive_regulation (caused) of Gene_expression (expression) of CD18 in PMN
7) Confidence 0.49 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
RESULTS: Indomethacin caused a concentration- and time-dependent upregulation of CD11b and CD18 expression and PMN adhesion to endothelial cells.
Positive_regulation (upregulation) of Gene_expression (expression) of CD18 in PMN
8) Confidence 0.49 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
NF-kappaB activation, CD11b/CD18 expression, and the production of TNF-alpha, IL-8, and IL-6 in monocytes and granulocytes were inhibited by NCR in vitro.
Positive_regulation (activation) of Gene_expression (expression) of CD18 in granulocytes
9) Confidence 0.49 Published 2005 Journal Shock Section Abstract Doc Link 16044078 Disease Relevance 0.37 Pain Relevance 0.36
The peak plasma levels of IL-8 (172.24 +/- 37.82 pg/mL at 12 hours) and vWF (256 +/- 42.32% at 4 hours) significantly increased after coronary angioplasty (both p < 0.01), and were associated with significant time course increases in surface expression of CD11b/CD18 (p < 0.01) and CD41 (p < 0.01).
Positive_regulation (increases) of Gene_expression (expression) of CD18 in plasma
10) Confidence 0.49 Published 2002 Journal Jpn Heart J Section Abstract Doc Link 12025897 Disease Relevance 0.98 Pain Relevance 0.95
We found that coronary angioplasty with stent implantation produces an increase in the cell surface expression of CD11b/CD18 in neutrophils and CD38 in monocytes, following a similar time-course with a peak after 24 h, returning to basal levels after 48 h and a second peak after 7 days.
Positive_regulation (following) of Gene_expression (expression) of CD18 in neutrophils
11) Confidence 0.45 Published 2004 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15080559 Disease Relevance 0.30 Pain Relevance 0.26
AIMS: To investigate whether indomethacin modulates: (1) Mac-1 expression; (2) Ca2+ mobilization ([Ca2+]i), protein kinase C and nitric oxide accumulation; and (3) mitogen-associated protein kinase phosphorylation in human PMN.
Positive_regulation (accumulation) of Gene_expression (expression) of Mac-1 in PMN
12) Confidence 0.42 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
We described previously that expression levels of the chemokine receptor, CCR5, and the beta2-integrin, Mac-1, were down-regulated on primary monocytes after incubation in supernatants from human carcinoma cell lines, and that this down-regulation resulted in impaired monocyte function with respect to migration and adhesion.
Positive_regulation (levels) of Gene_expression (expression) of Mac-1 in monocyte associated with chemokine, carcinoma and adhesions
13) Confidence 0.40 Published 2003 Journal FASEB J. Section Abstract Doc Link 12490541 Disease Relevance 0.49 Pain Relevance 0.14
We described previously that expression levels of the chemokine receptor, CCR5, and the beta2-integrin, Mac-1, were down-regulated on primary monocytes after incubation in supernatants from human carcinoma cell lines, and that this down-regulation resulted in impaired monocyte function with respect to migration and adhesion.
Positive_regulation (levels) of Gene_expression (expression) of beta2-integrin in monocyte associated with chemokine, carcinoma and adhesions
14) Confidence 0.40 Published 2003 Journal FASEB J. Section Abstract Doc Link 12490541 Disease Relevance 0.48 Pain Relevance 0.14
RESULTS: I/R plasma (withdrawn 15 min following tourniquet release) increased isolated neutrophil CD11b (P = 0.03), CD18 (P = 0.01) and endothelial intercellular adhesion molecule-1 (ICAM-1) (P = 0.008) expression compared to baseline.
Positive_regulation (increased) of Gene_expression (expression) of CD18 in neutrophil
15) Confidence 0.39 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15717706 Disease Relevance 0.06 Pain Relevance 0
However, expression of Mac-1 on neutrophils was increased in those with COPD, compared to either healthy group (smokers or non-smokers), augmented by an increased respiratory burst, leading the authors to suggest that neutrophil dysfunction in COPD subjects may not be directly caused by smoking, but, rather, may represent a characteristic of COPD.
Positive_regulation (increased) of Gene_expression (expression) of Mac-1 in respiratory associated with nicotine addiction and chronic obstructive pulmonary disease
16) Confidence 0.35 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.50 Pain Relevance 0
Recently, Koether et al. [20] exposed whole blood or neutrophils isolated from non-smokers to cigarette smoke condensate (CSC), and observed a rapid (minutes) 2.5 to 3 fold increase in CD18/CD11b expression on the neutrophil surface.
Positive_regulation (increase) of Gene_expression (expression) of CD18 in neutrophils associated with nicotine addiction
17) Confidence 0.35 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.85 Pain Relevance 0.03
However, expression of Mac-1 on neutrophils was increased in those with COPD, compared to either healthy group (smokers or non-smokers), augmented by an increased respiratory burst, leading the authors to suggest that neutrophil dysfunction in COPD subjects may not be directly caused by smoking, but, rather, may represent a characteristic of COPD.
Positive_regulation (increased) of Gene_expression (expression) of Mac-1 in respiratory associated with nicotine addiction and chronic obstructive pulmonary disease
18) Confidence 0.35 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 2.50 Pain Relevance 0
Recently, Koether et al. [20] exposed whole blood or neutrophils isolated from non-smokers to cigarette smoke condensate (CSC), and observed a rapid (minutes) 2.5 to 3 fold increase in CD18/CD11b expression on the neutrophil surface.
Positive_regulation (increase) of Gene_expression (expression) of CD18 in neutrophils associated with nicotine addiction
19) Confidence 0.35 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.85 Pain Relevance 0.03
Our results are in line with those of Sutter et al [26] who found increased cell surface expression of CD11b and CD18 by granulocytes and monocytes after tourniquet ischaemia during elective hand surgery.
Positive_regulation (increased) of Gene_expression (expression) of CD18 in granulocytes associated with cv unclassified under development
20) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.64 Pain Relevance 0.07

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