INT70327

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Context Info
Confidence 0.28
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 1.92
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
reticulum 6
brain 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Prostatitis 136 99.60 Very High Very High Very High
Glutamate receptor 2 91.08 High High
Inflammation 93 89.20 High High
Glutamate 10 88.60 High High
cytokine 37 88.16 High High
agonist 11 86.64 High High
antagonist 44 85.84 High High
Action potential 8 82.28 Quite High
Cannabinoid receptor 3 63.28 Quite High
cINOD 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Disease 143 99.72 Very High Very High Very High
Prostatitis 136 99.60 Very High Very High Very High
Aging 26 99.42 Very High Very High Very High
INFLAMMATION 103 89.20 High High
Bacterial Infection 46 86.96 High High
Stress 8 79.56 Quite High
Benign Prostatic Hypertrophy 6 70.88 Quite High
Diabetes Mellitus 9 57.20 Quite High
Alzheimer's Dementia 46 50.00 Quite Low
Bacterial Respiratory Disease 6 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two principal sources of Ca2+ affect the concentration of cytosolic Ca2+: internal Ca2+ stores, primarily in the endoplasmic reticulum (ER), and extracellular Ca2+.
Regulation (affect) of Gene_expression (stores) of Ca2 in reticulum
1) Confidence 0.28 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
Two principal sources of Ca2+ affect the concentration of cytosolic Ca2+: internal Ca2+ stores, primarily in the endoplasmic reticulum (ER), and extracellular Ca2+.
Regulation (affect) of Gene_expression (stores) of Ca2 in reticulum
2) Confidence 0.28 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
Two principal sources of Ca2+ affect the concentration of cytosolic Ca2+: internal Ca2+ stores, primarily in the endoplasmic reticulum (ER), and extracellular Ca2+.
Regulation (affect) of Gene_expression (sources) of Ca2 in reticulum
3) Confidence 0.28 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
The expression of CFTR and CAII is up-regulated in human prostatitis
Regulation (regulated) of Gene_expression (expression) of CAII associated with prostatitis
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.38 Pain Relevance 0.15
Ca2+-regulated S100 proteins
Regulation (regulated) of Gene_expression (proteins) of Ca2
5) Confidence 0.23 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Potential targets regulated by Ca2+ changes
Regulation (regulated) of Gene_expression (changes) of Ca2
6) Confidence 0.23 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
The range of [Ca2+]i values over which Pcat activation increases in all the RBCs was far above physiological [Ca2+]i levels; at the [Ca2+]s levels of 50 ?
Regulation (range) of Gene_expression (was) of Ca2
7) Confidence 0.22 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0 Pain Relevance 0
The range of [Ca2+]i values over which Pcat activation increases in all the RBCs was far above physiological [Ca2+]i levels; at the [Ca2+]s levels of 50 ?
Regulation (range) of Gene_expression (was) of Ca2
8) Confidence 0.22 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0 Pain Relevance 0
As shown in Figure 3B and 3C, mRNA and protein expression of CFTR and CAII were significantly up-regulated upon stimulation of E.coli-LPS, respectively.
Regulation (regulated) of Gene_expression (expression) of CAII
9) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.69 Pain Relevance 0.43
More specifically, why is the aging brain of an AD patient more sensitive to Ca2+ perturbations in general and the impact of A?
Regulation (sensitive) of Gene_expression (perturbations) of Ca2 in brain associated with aging and disease
10) Confidence 0.14 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.58 Pain Relevance 0.13
Specifically, what if these peptides were also capable of inserting as aberrant channels in intracellular Ca2+ stores?
Regulation (intracellular) of Gene_expression (stores) of Ca2
11) Confidence 0.14 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.21 Pain Relevance 0.08
Tyrosine kinase inhibitors prevented the effect of indomethacin on Mac-1 expression and Ca2+ mobilization.
Regulation (effect) of Gene_expression (expression) of Ca2
12) Confidence 0.13 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
Our data establish that KATP channel modulation has dramatic and direct effects on glucagon secretion and Ca2+ signalling in human ?
Regulation (effects) of Gene_expression (signalling) of Ca2
13) Confidence 0.10 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0.06 Pain Relevance 0.16

General Comments

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