INT70329

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 1999
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB2) plasma membrane (ITGB2) cell-cell signaling (ITGB2)
Anatomy Link Frequency
neutrophils 2
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 7 99.32 Very High Very High Very High
Enkephalin 6 97.94 Very High Very High Very High
Potency 1 85.92 High High
Inflammation 2 83.52 Quite High
cytokine 1 82.48 Quite High
Inflammatory response 1 79.60 Quite High
cINOD 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 48.00 Quite Low
Stress 1 46.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Indomethacin-induced upregulation of Mac-1 is mediated by changes in [Ca2+]i and nitric oxide.
Positive_regulation (mediated) of Positive_regulation (upregulation) of Mac-1
1) Confidence 0.67 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
Indomethacin-induced Mac-1 upregulation was prevented by a nitric oxide synthase inhibitor.
Positive_regulation (Indomethacin-induced) of Positive_regulation (upregulation) of Mac-1
2) Confidence 0.49 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
We have shown that: (1) met-enkephalin and beta-endorphin at physiological concentrations relevant to that of in vivo (10(-8) and 10(-6) M) enhanced fMLP, PMA or OZ stimulated chemiluminescence and induced chemotactic response, (2) High concentrations of beta-endorphin (10(-3) M) or met-enkephalin (10(-5) M) decreased the CL response of PMN in vitro, (3) The opioid peptides at lower concentrations resulted in CD11b and CD18 molecule up-regulation on neutrophils.
Positive_regulation (resulted) of Positive_regulation (up-regulation) of CD18 in neutrophils associated with enkephalin and opioid
3) Confidence 0.41 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0 Pain Relevance 1.06

General Comments

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