INT7033

Context Info Confidence 0.37 First Reported 1989 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 19 Total Number 19 Disease Relevance 6.66 Pain Relevance 1.52

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)

Anatomy Link Frequency follicle 7 urine 2 pituitary 1 FSHR (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 78 100.00 Endogenous opioid 3 99.64 narcan 10 99.24 Dopamine 3 99.08 opiate 2 98.96 antagonist 53 98.76 Catecholamine 1 98.30 alcohol 7 90.36 dexamethasone 7 88.52 Opioid 17 87.12

Disease Link Frequency Relevance Heat Reprotox - General 1 139 98.56 Stress 13 97.66 Hypogonadotropic Hypogonadism 74 97.60 Endocrine Disease 1 96.28 Galactorrhea 38 92.88 Reprotox - General 3 111 92.56 Alcohol Addiction 4 90.60 Ovarian Hyperstimulation Syndrome 30 89.60 Klinefelter Syndrome 2 88.04 Infection 5 84.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Follicle stimulating hormone (FSH) has been widely employed for ovulation induction and in-vitro fertilization.

Follicle stimulating hormone Binding (employed) of in Follicle

1) Confidence 0.37 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0

Follicle stimulating hormone (FSH) has been widely employed for ovulation induction and in-vitro fertilization.

FSH Binding (employed) of in Follicle

2) Confidence 0.37 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0

This ELISA is based on the dissociation of the FSH heterodimer in urine and the subsequent measurement of the beta subunit as a representation of total urinary FSH.

FSH Binding (dissociation) of in urine

3) Confidence 0.36 Published 1999 Journal Am. J. Primatol. Section Abstract Doc Link 10333433 Disease Relevance 0.17 Pain Relevance 0

We identified 9 relevant randomized controlled trials that compared recombinant FSH with urinary gonadotropins.25–33 One trial was excluded as it studied differential effects on hemostasis.32 A further 2 trials were excluded as pregnancy results after 1 treatment cycle could not be extracted.29,33 Two trials reported the data of 3 treatment cycles, without reporting the results of the first treatment cycle.29,33

FSH Binding (recombinant) of

4) Confidence 0.34 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.21 Pain Relevance 0

They possess similar alpha but different specific beta subunits.18,19 The nomenclature “alpha” differentiates it from another recombinant human FSH product which was marketed later as follitropin beta.20 Isoforms

FSH product Binding (recombinant) of

5) Confidence 0.25 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0 Pain Relevance 0

Later Noci et al. [20] updated their findings on 249 IVF cycles, when GnRH agonist desensitisation was used and stimulation with HP-FSH.

FSH Binding (findings) of associated with agonist

6) Confidence 0.24 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0 Pain Relevance 0.11

Letrozole-FSH and tamoxifen-alone stimulation were associated with significantly lower peak estradiol levels than tamoxifen-FSH stimulation.

Letrozole-FSH Binding (associated) of

7) Confidence 0.21 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397531 Disease Relevance 0.56 Pain Relevance 0.05

The receptors for the glycoprotein hormones thyroid-stimulating hormone (TSH), luteinizing hormone (LSH) and follicle-stimulating hormone (FSH) make up Group A10.

FSH Binding (receptors) of in follicle

8) Confidence 0.16 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.04

The receptors for the glycoprotein hormones thyroid-stimulating hormone (TSH), luteinizing hormone (LSH) and follicle-stimulating hormone (FSH) make up Group A10.

follicle-stimulating hormone Binding (receptors) of in follicle

9) Confidence 0.16 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.04

Recombinant FSH

FSH Binding (Recombinant) of

10) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.25 Pain Relevance 0.05

Stress hormones such as catecholamines (adrenalin, nonadrenaline and dopamine) and the hypothalamic-pituitary-adrenal axis interact with hormones which are responsible for normal ovulatory cycles: i.e., gonadotropin releasing hormone (GnRH), prolactin, LH and FSH.

FSH Binding (interact) of in pituitary associated with stress, dopamine and catecholamine

11) Confidence 0.12 Published 1992 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 1618356 Disease Relevance 1.39 Pain Relevance 0.20

It is also associated with low or low-normal FSH and LH levels.

FSH Binding (associated) of

12) Confidence 0.12 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 1.82 Pain Relevance 0.05

Oestradiol, follicle-stimulating hormone, luteinizing hormone and tyrosine kinase activity

follicle-stimulating hormone Binding (activity) of in follicle

13) Confidence 0.11 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400670 Disease Relevance 0.13 Pain Relevance 0

At the completion of the urine collection, participants had blood drawn for calcium, phosphorus, parathyroid hormone (PTH), parathyroid related protein (PTH-rP), 1,25-(OH)2 vitamin D, albumin, bone specific alkaline phosphatase, estradiol, luteinizing hormone (LH) and follicle stimulating hormone (FSH).

FSH Binding (drawn) of in urine

14) Confidence 0.09 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.44 Pain Relevance 0

Commercial kits for radioimmunoassay were used to determine the serum concentrations of testosterone (Medgenics Diagnostics, Fleurus, Belgium); commercial kits for immuradiometric assays were used for determinations of LH and FSH (Medgenics Diagnostics).

FSH Binding (determinations) of

15) Confidence 0.05 Published 2006 Journal BMC Urol Section Body Doc Link PMC1444919 Disease Relevance 0.21 Pain Relevance 0

Deletion analysis identified a 358 bp fragment as the primary hormone-responsive sequence (-1858 to -1500 bp; containing three potential cAMP-responsive elements); its deletion resulted in severely reduced FSH responsiveness, and its ligation to hormone-unresponsive basal promoter sequences completely restored FSH responsiveness.

FSH Binding (ligation) of

16) Confidence 0.03 Published 1992 Journal Mol. Endocrinol. Section Abstract Doc Link 1337148 Disease Relevance 0 Pain Relevance 0

Hormonal assay: FSH, LH, Testosterone, TSH and Prolactin (for male with abnormal seminal analysis and suspected endocrine disorder)

FSH Binding (assay) of associated with endocrine disease

17) Confidence 0.03 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2844387 Disease Relevance 1.30 Pain Relevance 0.13

Sera were assayed for luteinizing hormone (LH), follicle-stimulating hormone (FSH) and cortisol by RIA.

follicle-stimulating hormone Binding (assayed) of in follicle

18) Confidence 0.03 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2498756 Disease Relevance 0 Pain Relevance 0.29

Modulation of luteinizing hormone and follicle-stimulating hormone in circulation by interactions between endogenous opioids and oestradiol during the peripubertal period of heifers.

follicle-stimulating hormone Binding (interactions) of in follicle associated with narcan and endogenous opioid

19) Confidence 0.03 Published 1992 Journal J. Reprod. Fertil. Section Title Doc Link 1432947 Disease Relevance 0.17 Pain Relevance 0.58

General Comments

This test has worked.