INT7035

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Context Info
Confidence 0.45
First Reported 1980
Last Reported 2010
Negated 10
Speculated 11
Reported most in Abstract
Documents 87
Total Number 98
Disease Relevance 29.04
Pain Relevance 28.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGA) small molecule metabolic process (CGA) extracellular region (CGA)
cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
Anatomy Link Frequency
follicle 8
pituitary 6
plasma 4
blood 3
brain 2
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 149 100.00 Very High Very High Very High
Morphine 36 100.00 Very High Very High Very High
methadone 15 100.00 Very High Very High Very High
ketamine 8 100.00 Very High Very High Very High
Serotonin 8 100.00 Very High Very High Very High
anesthesia 4 100.00 Very High Very High Very High
nalbuphine 3 100.00 Very High Very High Very High
Opioid 50 99.98 Very High Very High Very High
Endogenous opioid 35 99.98 Very High Very High Very High
cINOD 29 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anovulation 30 100.00 Very High Very High Very High
Cancer 42 99.88 Very High Very High Very High
Endometriosis (extended) 68 99.80 Very High Very High Very High
Empty Sella Syndrome 2 99.72 Very High Very High Very High
Aging 2 99.48 Very High Very High Very High
Reprotox - General 2 53 99.20 Very High Very High Very High
Dysmenorrhea 22 99.16 Very High Very High Very High
Reprotox - General 3 73 99.04 Very High Very High Very High
Pain 21 99.04 Very High Very High Very High
Reprotox - General 1 54 98.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, since clinical evidence shows that pregnancy leads to alleviation of endometriotic symptoms, we have for the first time examined the effect of human chorionic gonadotrophin (HCG) injections on symptoms such as dysmenorrhea and pelvic pain.
Spec (examined) Regulation (effect) of HCG associated with endometriosis, pain pelvic and dismenorea
1) Confidence 0.45 Published 2004 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 15690968 Disease Relevance 0.69 Pain Relevance 0.52
Immunohistochemically, the tumors were notable for strong keratin and beta-human chorionic gonadotropin (HCG) positivity.
Regulation (notable) of chorionic gonadotropin associated with cancer
2) Confidence 0.45 Published 1997 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9298876 Disease Relevance 1.38 Pain Relevance 0.07
Control follow-up was performed using beta-human chorionic gonadotropin (HCG) testing on a weekly basis during the first month and then bi-monthly during the first year of follow-up.
Regulation (using) of HCG
3) Confidence 0.45 Published 2004 Journal Int. J. Gynecol. Cancer Section Abstract Doc Link 15361223 Disease Relevance 1.10 Pain Relevance 0.17
Immunohistochemically, the tumors were notable for strong keratin and beta-human chorionic gonadotropin (HCG) positivity.
Regulation (notable) of HCG associated with cancer
4) Confidence 0.45 Published 1997 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9298876 Disease Relevance 1.38 Pain Relevance 0.07
[Influence of human chorionic gonadotropin (hCG) in combination with a 500 calorie diet on clinical and laboratory parameters in premenopausal women with and without hormonal contraception].
Regulation ([Influence) of hCG
5) Confidence 0.45 Published 1987 Journal Aktuel Endokrinol Stoffwechsel Section Title Doc Link 12281505 Disease Relevance 0.12 Pain Relevance 0
It was found that for any given false-positive rate, subnormal rates of hCG increase were more sensitive in identifying ectopic gestations than single "low for date" hCG values.
Regulation (sensitive) of hCG
6) Confidence 0.44 Published 1982 Journal Fertil. Steril. Section Abstract Doc Link 7067849 Disease Relevance 0.40 Pain Relevance 0.08
Neither PGE2 nor any of the two NSAID altered the basal levels of FSH or LH significantly.
Neg (Neither) Regulation (altered) of FSH associated with cinod
7) Confidence 0.40 Published 1992 Journal Eicosanoids Section Abstract Doc Link 1419076 Disease Relevance 0.09 Pain Relevance 0.28
The effect of PGE2 or PG synthesis inhibitors on gonadotrophin and prolactin (PRL) levels was evaluated in 50 volunteers (25 males and 25 females).
Regulation (effect) of gonadotrophin
8) Confidence 0.40 Published 1992 Journal Eicosanoids Section Abstract Doc Link 1419076 Disease Relevance 0.08 Pain Relevance 0.22
The role of a single free beta-human chorionic gonadotrophin measurement in the diagnosis of early pregnancy failure and the prognosis of fetal viability.
Regulation (role) of gonadotrophin
9) Confidence 0.40 Published 1996 Journal Hum. Reprod. Section Title Doc Link 8671345 Disease Relevance 0.77 Pain Relevance 0.17
However, since clinical evidence shows that pregnancy leads to alleviation of endometriotic symptoms, we have for the first time examined the effect of human chorionic gonadotrophin (HCG) injections on symptoms such as dysmenorrhea and pelvic pain.
Spec (examined) Regulation (effect) of chorionic gonadotrophin associated with endometriosis, pain pelvic and dismenorea
10) Confidence 0.40 Published 2004 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 15690968 Disease Relevance 0.69 Pain Relevance 0.52
Control follow-up was performed using beta-human chorionic gonadotropin (HCG) testing on a weekly basis during the first month and then bi-monthly during the first year of follow-up.
Regulation (using) of gonadotropin
11) Confidence 0.40 Published 2004 Journal Int. J. Gynecol. Cancer Section Abstract Doc Link 15361223 Disease Relevance 1.10 Pain Relevance 0.17
[Influence of human chorionic gonadotropin (hCG) in combination with a 500 calorie diet on clinical and laboratory parameters in premenopausal women with and without hormonal contraception].
Regulation ([Influence) of gonadotropin
12) Confidence 0.39 Published 1987 Journal Aktuel Endokrinol Stoffwechsel Section Title Doc Link 12281505 Disease Relevance 0.12 Pain Relevance 0
The 75 IU rLH dose was found to be effective in 94% of the treatment cycles.36 The cumulative pregnancy rate following three cycles of stimulation with follitropin alpha and lutropin alpha was 39.5%.36 Clinical pregnancy occurred in 16 out of the 31 women received lutropin alpha with follitropin alpha in an extension phase of the randomized trial published by O’Dea et al in 2000 on severely hypogonadotrophic women.116 Two case reports documented pregnancies in 2 women with Kallman syndrome (amenorrhea, anosmia and hypogonadotrophic hypogonadism) and empty sella syndrome who received follitropin alpha and rLH.117,118

WHO group II anovulation

Regulation (anovulation) of follitropin alpha in sella associated with reprotox - general 2, syndrome, anovulation, empty sella syndrome, loss of sense of smell and reprotox - general 1
13) Confidence 0.38 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 1.10 Pain Relevance 0
Effect of naloxone, nalbuphine, progesterone and pregnant mare's serum gonadotrophin on the sexual behaviour of ewes.
Regulation (Effect) of gonadotrophin associated with nalbuphine and narcan
14) Confidence 0.34 Published 1989 Journal Vet. Rec. Section Title Doc Link 2523615 Disease Relevance 0 Pain Relevance 0.70
No evidence of a stimulatory FSH or LH response to naltrexone was found in any of the patients evaluated.
Regulation (response) of FSH
15) Confidence 0.27 Published 1987 Journal J. Androl. Section Abstract Doc Link 3123447 Disease Relevance 0 Pain Relevance 0.34
OBJECTIVE: To determine the association between endometrial stripe (ES) thickness and pregnancy outcome in women with a symptomatic first-trimester pregnancy and to determine how vaginal bleeding, pelvic pain and 1 human chorionic gonadotropin (hCG) level affect ES thickness.
Regulation (affect) of hCG associated with pain pelvic and reprotox - general 1
16) Confidence 0.27 Published 2007 Journal J Reprod Med Section Abstract Doc Link 17939589 Disease Relevance 0.35 Pain Relevance 0.17
The minimal rise in serial hCG values for women with a viable intrauterine pregnancy is "slower" than previously reported, suggesting that intervention to diagnosis and treat an abnormal gestation should be more conservative.


Regulation (values) of hCG
17) Confidence 0.27 Published 2004 Journal Obstet Gynecol Section Body Doc Link 15229000 Disease Relevance 0 Pain Relevance 0
CONCLUSION: These data define the slowest rise in serial hCG values for a potentially viable gestation and will aid in distinguishing a viable early pregnancy from a miscarriage or ectopic pregnancy.
Regulation (values) of hCG
18) Confidence 0.27 Published 2004 Journal Obstet Gynecol Section Body Doc Link 15229000 Disease Relevance 0 Pain Relevance 0
When the initial hCG value is low, serial hCG values can be used to determine whether a gestation is potentially viable or spontaneously resolving.
Regulation (values) of hCG
19) Confidence 0.27 Published 2006 Journal Obstet Gynecol Section Abstract Doc Link 16449130 Disease Relevance 1.07 Pain Relevance 0.13
OBJECTIVE: To analyze the change in serial human chorionic gonadotropin (hCG) levels in women symptomatic with pain or bleeding who presented with nondiagnostic ultrasonography but were ultimately confirmed to have a viable intrauterine pregnancy.
Spec (analyze) Regulation (change) of hCG associated with pain and hemorrhage
20) Confidence 0.27 Published 2004 Journal Obstet Gynecol Section Abstract Doc Link 15229000 Disease Relevance 0.20 Pain Relevance 0.10

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