INT70356

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Context Info
Confidence 0.74
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.11
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIN2D) plasma membrane (GRIN2D)
Anatomy Link Frequency
projection neurons 2
interneurons 2
blood 1
neuronal 1
cerebrospinal fluid 1
GRIN2D (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 24 100.00 Very High Very High Very High
Glutamate receptor 10 100.00 Very High Very High Very High
intrathecal 6 99.98 Very High Very High Very High
projection neuron 12 99.84 Very High Very High Very High
mu opioid receptor 10 99.36 Very High Very High Very High
Opioid 21 98.16 Very High Very High Very High
addiction 9 97.88 Very High Very High Very High
Glutamate 4 95.32 Very High Very High Very High
methadone 8 95.12 Very High Very High Very High
Neurotransmitter 6 92.08 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 8 98.16 Very High Very High Very High
Teratocarcinoma 2 93.84 High High
Ovarian Cancer 4 86.76 High High
Apoptosis 2 84.96 Quite High
Encephalopathy 3 83.96 Quite High
Generalized Anxiety Disorder 12 75.92 Quite High
Encephalitis 5 75.00 Quite High
Schizophrenia 100 72.48 Quite High
Cancer 65 63.04 Quite High
Depression 2 49.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inducible expression of N-methyl-D-aspartate receptor, and delta and mu opioid receptor messenger RNAs and protein in the NT2-N human cell line.
Gene_expression (expression) of N-methyl-D-aspartate receptor associated with nmda receptor and mu opioid receptor
1) Confidence 0.74 Published 1997 Journal Neuroscience Section Title Doc Link 9219948 Disease Relevance 0.09 Pain Relevance 0.44
We used a dual-label in situ hybridization technique to assess the levels of NR1 and NR2A-D messenger ribonucleic acid (mRNA) expressed in projection neurons and interneurons of the human striatum.
Gene_expression (levels) of NR2A-D in interneurons associated with projection neuron
2) Confidence 0.71 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10742712 Disease Relevance 0.13 Pain Relevance 0.31
Expression of NR3B but not NR2D subunit of NMDA receptor in human blood lymphocytes can serve as a suitable peripheral marker for opioid addiction studies.
Gene_expression (Expression) of NR2D subunit in blood associated with addiction, nmda receptor and opioid
3) Confidence 0.64 Published 2010 Journal Eur. J. Pharmacol. Section Title Doc Link 20153313 Disease Relevance 0.30 Pain Relevance 0.96
As a conclusion, our data indicate that the transcriptional level of the NR2D subunit of NMDA receptor is not regulated by chronic opioid addiction.
Gene_expression (level) of NR2D subunit associated with addiction, nmda receptor and opioid
4) Confidence 0.56 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20153313 Disease Relevance 0.32 Pain Relevance 1.24
We used a dual-label in situ hybridization technique to assess the levels of NR1 and NR2A-D messenger ribonucleic acid (mRNA) expressed in projection neurons and interneurons of the human striatum.
Gene_expression (expressed) of NR2A-D in interneurons associated with projection neuron
5) Confidence 0.55 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10742712 Disease Relevance 0.14 Pain Relevance 0.35
Concomitant with their terminal differentiation into neurons, NT2 cells are induced by retinoic acid to express neuronal N-methyl-D-aspartate receptor channels, which are fully functional.
Gene_expression (express) of N-methyl-D-aspartate receptor in neuronal associated with nmda receptor
6) Confidence 0.50 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219948 Disease Relevance 0.09 Pain Relevance 0.36
Among those loops, the one from N-methyl-D-aspartate subtype glutamate receptor (NMDAR) to ?
Gene_expression (one) of N-methyl-D-aspartate subtype glutamate receptor associated with glutamate receptor
7) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894047 Disease Relevance 0.46 Pain Relevance 0.30
Although there was marked intrathecal synthesis of N-methyl-d-aspartate receptor antibodies, the absolute levels of N-methyl-d-aspartate receptor antibodies were higher in serum than in cerebrospinal fluid.
Gene_expression (synthesis) of N-methyl-d-aspartate receptor in cerebrospinal fluid associated with intrathecal
8) Confidence 0.31 Published 2010 Journal Brain Section Abstract Doc Link PMC2877907 Disease Relevance 0.31 Pain Relevance 0.09
We used a dual-label in situ hybridization technique to assess the levels of NR1 and NR2A-D messenger ribonucleic acid (mRNA) expressed in projection neurons and interneurons of the human striatum.
Gene_expression (levels) of NR2A-D in projection neurons associated with projection neuron
9) Confidence 0.24 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10742712 Disease Relevance 0.13 Pain Relevance 0.31
We used a dual-label in situ hybridization technique to assess the levels of NR1 and NR2A-D messenger ribonucleic acid (mRNA) expressed in projection neurons and interneurons of the human striatum.
Gene_expression (expressed) of NR2A-D in projection neurons associated with projection neuron
10) Confidence 0.19 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10742712 Disease Relevance 0.14 Pain Relevance 0.35

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