INT70357

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.61
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIN2D) plasma membrane (GRIN2D)
Anatomy Link Frequency
lymphocytes 1
interneurons 1
GRIN2D (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 13 100.00 Very High Very High Very High
Pyramidal cell 59 99.62 Very High Very High Very High
Glutamate receptor 2 98.92 Very High Very High Very High
Opioid 17 97.64 Very High Very High Very High
opioid receptor 6 97.52 Very High Very High Very High
mu opioid receptor 5 97.12 Very High Very High Very High
methadone 8 95.44 Very High Very High Very High
Neurotransmitter 2 94.72 High High
ketamine 75 94.08 High High
addiction 6 92.92 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 8 92.92 High High
Hallucination 3 55.24 Quite High
Teratocarcinoma 1 54.20 Quite High
Confusion 1 51.76 Quite High
Unconsciousness 14 50.00 Quite Low
Sleep Disorders 1 49.48 Quite Low
Delirium 1 41.44 Quite Low
Psychosis 2 40.12 Quite Low
Body Weight 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that NR2D subunit mRNA expression was not changed in all three test groups in comparison to control subjects.
Transcription (expression) of NR2D subunit
1) Confidence 0.68 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20153313 Disease Relevance 0.28 Pain Relevance 0.98
In the present study, using Real-time PCR, the mRNA expression of NR2D and NR3B subunits of NMDA glutamate receptor has been investigated in peripheral blood lymphocytes of four groups each comprising of 25 male individuals: opioid addicts, methadone maintained patients, long-term abstinent former opioid addicts, and non-addicted control subjects.
Transcription (expression) of NR2D in lymphocytes associated with glutamate receptor, methadone and opioid
2) Confidence 0.68 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20153313 Disease Relevance 0.17 Pain Relevance 0.76
For example, NR2A and NR2B mRNA are expressed mainly in pyramidal cells, whereas NR2C and NR2D mRNA are present in different subsets of hippocampal interneurons [27]–[30].
Transcription (present) of NR2D in interneurons associated with pyramidal cell
3) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999569 Disease Relevance 0.11 Pain Relevance 0.74
Northern blot analysis revealed two transcripts for the N-methyl-D-aspartate receptor messenger RNA (4.2 and 4.4 kb) and two transcripts for delta opioid receptor messenger RNA (7.0 and 11.0 kb).
Transcription (transcripts) of N-methyl-D-aspartate receptor associated with nmda receptor and opioid receptor
4) Confidence 0.44 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219948 Disease Relevance 0.05 Pain Relevance 0.68

General Comments

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