INT70359

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.33
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal) Golgi apparatus (Gal) response to stress (Gal)
cytoplasm (Gal)
Anatomy Link Frequency
dorsal root ganglion 4
Gal (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 99.84 Very High Very High Very High
Sciatic nerve 13 99.80 Very High Very High Very High
dorsal root ganglion 5 99.40 Very High Very High Very High
Root ganglion neuron 4 98.64 Very High Very High Very High
gracile nuclei 2 95.68 Very High Very High Very High
Dorsal horn 2 90.48 High High
antagonist 1 86.08 High High
Neuropeptide 4 75.92 Quite High
Neuropathic pain 1 73.76 Quite High
medulla 1 43.76 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 10 99.98 Very High Very High Very High
Ganglion Cysts 9 99.40 Very High Very High Very High
Injury 4 91.20 High High
Neuropathic Pain 1 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since only 2-3% of neurons in the contralateral uninjured DRG were GAL mRNA positive, PSNL induced up-regulation of GAL mRNA in both injured and spared DRG neurons.
Positive_regulation (induced) of Regulation (regulation) of GAL in DRG associated with dorsal root ganglion
1) Confidence 0.45 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10218889 Disease Relevance 0.60 Pain Relevance 0.45
We conclude that partial sciatic nerve injuries induced greater galanin up-regulation in medium- and large-size dorsal root ganglion neurons than complete sciatic nerve injury.
Spec (partial) Positive_regulation (induced) of Regulation (regulation) of galanin in dorsal root ganglion associated with ganglion cysts, nervous system injury, root ganglion neuron and sciatic nerve
2) Confidence 0.41 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219977 Disease Relevance 0.73 Pain Relevance 0.44
Tetrodotoxin (TTX) did not suppress the galanin excitatory effect, whereas the effect of galanin 1-16 on gastric contraction was increased by TTX- or N-nitro-L-arginine, an inhibitor of nitric oxide synthase.
Positive_regulation (increased) of Regulation (effect) of galanin associated with tetrodotoxin
3) Confidence 0.32 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15305998 Disease Relevance 0 Pain Relevance 0.34

General Comments

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