INT7036

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Context Info
Confidence 0.29
First Reported 1987
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.14
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 3 96.00 Very High Very High Very High
Endogenous opioid 1 80.00 Quite High
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypogonadotropic Hypogonadism 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum testosterone remained undetectable less than 1.0 nmol/l, the hyporesponsiveness of serum LH was not improved, but basal FSH level was significantly increased and the impaired FSH response to the standard GnRH test was slightly improved.
Negative_regulation (impaired) of Regulation (response) of FSH
1) Confidence 0.29 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3101337 Disease Relevance 0.14 Pain Relevance 0.17
Deletion analysis identified a 358 bp fragment as the primary hormone-responsive sequence (-1858 to -1500 bp; containing three potential cAMP-responsive elements); its deletion resulted in severely reduced FSH responsiveness, and its ligation to hormone-unresponsive basal promoter sequences completely restored FSH responsiveness.
Negative_regulation (reduced) of Regulation (responsiveness) of FSH
2) Confidence 0.04 Published 1992 Journal Mol. Endocrinol. Section Abstract Doc Link 1337148 Disease Relevance 0 Pain Relevance 0

General Comments

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