INT70362

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.01
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GH1) extracellular region (GH1)
Anatomy Link Frequency
oocytes 1
GH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 25 99.96 Very High Very High Very High
Somatostatin 25 95.40 Very High Very High Very High
Enkephalin 3 87.24 High High
imagery 11 75.84 Quite High
agonist 24 67.24 Quite High
headache 8 54.24 Quite High
Pain 6 51.52 Quite High
visual analogue scale 2 49.44 Quite Low
abdominal pain 2 38.56 Quite Low
cytokine 4 31.16 Quite Low
Disease Link Frequency Relevance Heat
Acromegaly 41 98.16 Very High Very High Very High
Repression 6 96.52 Very High Very High Very High
Chronic Renal Failure 42 94.88 High High
Apoptosis 11 85.36 High High
Body Weight 5 84.92 Quite High
Renal Failure 5 79.40 Quite High
Targeted Disruption 19 79.12 Quite High
Cancer 27 78.96 Quite High
Hypoglycemia 5 77.80 Quite High
Diabetes Mellitus 9 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A PK study of intravenous GH administration found a strong positive correlation between baseline GHBP concentration and MCR at physiological GH concentrations.39 In addition, the reduced GH elimination rate observed in GH-deficient patients in another study was explained by lower levels of GHBP, possibly reflecting a reduced GH receptor density and hence clearance.40
Transcription (density) of GH
1) Confidence 0.56 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.54 Pain Relevance 0
Instead, she was initiated on the GH antagonist pegvisomant (Somavert®, Pfizer, UK) at a dosage of 120 mg/day and her lanreotide treatment was stopped.
Transcription (initiated) of GH associated with antagonist
2) Confidence 0.53 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.77 Pain Relevance 0.14
Specific expression of testicular GH/PL mRNA (n = 20) was shown by reverse transcription-polymerase chain reaction (RT-PCR) using a pair of primers designed to non-selectively amplify any transcript of the five GH/PL genes (GH-N, GH-V, PL-A, PL-B, PL-L).
Transcription (transcript) of GH
3) Confidence 0.13 Published 1997 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 9220021 Disease Relevance 0 Pain Relevance 0.08
Specific expression of testicular GH/PL mRNA (n = 20) was shown by reverse transcription-polymerase chain reaction (RT-PCR) using a pair of primers designed to non-selectively amplify any transcript of the five GH/PL genes (GH-N, GH-V, PL-A, PL-B, PL-L).
Transcription (transcript) of GH-N
4) Confidence 0.13 Published 1997 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 9220021 Disease Relevance 0 Pain Relevance 0.08
mRNA transcripts for the GH receptor are expressed in human oocytes and throughout pre-implantation embryonic development [123,124].
Transcription (transcripts) of GH in oocytes
5) Confidence 0.11 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764709 Disease Relevance 0.09 Pain Relevance 0
Specific expression of testicular GH/PL mRNA (n = 20) was shown by reverse transcription-polymerase chain reaction (RT-PCR) using a pair of primers designed to non-selectively amplify any transcript of the five GH/PL genes (GH-N, GH-V, PL-A, PL-B, PL-L).
Transcription (expression) of GH
6) Confidence 0.11 Published 1997 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 9220021 Disease Relevance 0 Pain Relevance 0.09
Acylated ghrelin, unlike GHRH, does not induce GH-gene transcription.
Transcription (transcription) of GH-gene
7) Confidence 0.10 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.26 Pain Relevance 0.10
To determine similar efficacy, steady-state GH concentrations with Lan ATG and Lan MP were determined, and the quotient of the GH concentrations calculated.
Transcription (concentrations) of GH
8) Confidence 0.05 Published 2006 Journal Clinical Endocrinology Section Body Doc Link PMC1618957 Disease Relevance 0.20 Pain Relevance 0.10
Group 2 serum GH and IGF-1 levels were not significantly decreased at the end of the 1st trimester (GH: 27.2 +/- 12.1 ng/ml, NS.
Transcription (end) of GH
9) Confidence 0.02 Published 2001 Journal Horm. Metab. Res. Section Abstract Doc Link 11607883 Disease Relevance 0.16 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox