INT70377

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2006
Negated 0
Speculated 3
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0.93
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
hypothalamus 2
NAc 2
forebrain 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 25 100.00 Very High Very High Very High
mu opioid receptor 12 100.00 Very High Very High Very High
Morphine 6 100.00 Very High Very High Very High
addiction 4 100.00 Very High Very High Very High
Nucleus accumbens 6 99.68 Very High Very High Very High
Opioid 4 99.12 Very High Very High Very High
Lasting pain 1 97.48 Very High Very High Very High
tolerance 3 95.60 Very High Very High Very High
Analgesic 1 93.60 High High
Physical dependence 1 91.24 High High
Disease Link Frequency Relevance Heat
Stress 8 98.78 Very High Very High Very High
Drug Dependence 2 97.96 Very High Very High Very High
Pain 1 97.48 Very High Very High Very High
Morphine Dependence 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the participation of the opioid system in this phenomenon, we examined the effects of acute and repeated AMPH administration on mu-opioid receptor (MOR) mRNA levels in the nucleus accumbens (NAc) and striatum (STR) of rats, by quantitative non-radioactive in situ hybridization.
Spec (examined) Regulation (effects) of Transcription (levels) of mu-opioid receptor in NAc associated with nucleus accumbens, opioid receptor and opioid
1) Confidence 0.47 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10350632 Disease Relevance 0 Pain Relevance 0.59
This study tested the hypothesis that stress-induced opioid peptides may have stimulative and inhibitive influence on mu opioid receptor (MOR) mRNA expression and hypothalamus.
Regulation (influence) of Transcription (expression) of mu opioid receptor in hypothalamus associated with stress, mu opioid receptor and opioid
2) Confidence 0.44 Published 2003 Journal Brain Res. Section Abstract Doc Link 12867258 Disease Relevance 0.50 Pain Relevance 0.42
The present study aimed to analyze the long-term effects of a brief handling (1 min) on morphine and ethanol dependence and on the preproenkephalin (PPE) mRNA and mu opioid receptor levels.
Spec (analyze) Regulation (effects) of Transcription (levels) of mu opioid receptor associated with addiction, mu opioid receptor and morphine
3) Confidence 0.40 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16567006 Disease Relevance 0.24 Pain Relevance 0.69
The present study examined whether estrogen treatment alters mu-opioid receptor mRNA levels in different areas of the forebrain of ovariectomized (OVX) female rats using the in situ hybridization technique.
Spec (whether) Regulation (alters) of Transcription (levels) of mu-opioid receptor in forebrain associated with opioid receptor
4) Confidence 0.24 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221910 Disease Relevance 0 Pain Relevance 0.35
Transcriptional regulation of mu opioid receptor gene by cAMP pathway.
Regulation (regulation) of Transcription (Transcriptional) of mu opioid receptor gene associated with mu opioid receptor
5) Confidence 0.02 Published 2003 Journal Mol. Pharmacol. Section Title Doc Link 14645671 Disease Relevance 0.19 Pain Relevance 0.74

General Comments

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