INT70380

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.43
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Anatomy Link Frequency
PeVN 1
VMN 1
Prep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 628 100.00 Very High Very High Very High
alcohol 6 89.72 High High
gABA 4 83.20 Quite High
ischemia 23 66.64 Quite High
Enkephalin 2 25.00 Low Low
anesthesia 9 5.00 Very Low Very Low Very Low
Catecholamine 9 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 16 69.24 Quite High
Cv Unclassified Under Development 23 66.64 Quite High
Body Weight 6 64.44 Quite High
Contracture 9 63.52 Quite High
Reperfusion Injury 3 50.00 Quite Low
Atherosclerosis 7 35.08 Quite Low
Disorder Of Lipid Metabolism 10 25.04 Quite Low
Aids-related Complex 8 5.88 Low Low
Myocardial Infarction 11 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proenkephalin (PE) mRNA expression in the VMN is dramatically increased by estrogen and this elevation is thought to be involved in modulating female reproductive behavior and neuroendocrine function.
Transcription (expression) of PE in VMN
1) Confidence 0.62 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221919 Disease Relevance 0 Pain Relevance 0.16
There was no significant differences between control group and vitamin B6 deficient group in post-exercise and recess after exercise because GSH/GSSG ratio of control group was decreased with exercise but those of vitamin B6 deficient groups was not significantly changed in post-exercise and recess after exercise.
Neg (not) Transcription (changed) of post-exercise
2) Confidence 0.04 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2808720 Disease Relevance 0.13 Pain Relevance 0
However, several other studies showed that the effects of OVX on SOM mRNA levels in the PeVN could be reversed by E2 (Baldino et al. 1988; Werner et al. 1988; Zorilla et al. 1990).
Transcription (levels) of PeVN associated with somatostatin
3) Confidence 0.04 Published 2008 Journal Exp Brain Res Section Body Doc Link PMC2441535 Disease Relevance 0 Pain Relevance 0.62
expression was not found in the PeVN at all (Kamegai et al. 2001; Simonian and Herbison 1997).
Neg (not) Transcription (found) of PeVN
4) Confidence 0.03 Published 2008 Journal Exp Brain Res Section Body Doc Link PMC2441535 Disease Relevance 0 Pain Relevance 0.59
This study is the first to describe SOM cell distribution within the rat PeVN in great detail.
Transcription (describe) of PeVN in PeVN associated with somatostatin
5) Confidence 0.03 Published 2008 Journal Exp Brain Res Section Abstract Doc Link PMC2441535 Disease Relevance 0 Pain Relevance 0.61
In contrast, SOM mRNA levels in the PeVN also decrease following OVX, but this reduction can be reversed by treatment with E2 (Bethea et al. 1992; Werner et al. 1988; Zorilla et al. 1990).
Transcription (levels) of PeVN associated with somatostatin
6) Confidence 0.03 Published 2008 Journal Exp Brain Res Section Body Doc Link PMC2441535 Disease Relevance 0 Pain Relevance 0.46
In particular, at the end of reperfusion the recovery was 52 ± 10% (P < 0.05) and 63 ± 23% (P < 0.05) of baseline levels for PostC and CST-Post, respectively (Fig. 3a).
Transcription (levels) of PostC
7) Confidence 0.01 Published 2010 Journal Cell Mol Neurobiol Section Body Doc Link PMC3008938 Disease Relevance 0.30 Pain Relevance 0.09

General Comments

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