INT70387

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 3.76
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
joints 2
sensory neurons 2
lymph node 2
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 151 100.00 Very High Very High Very High
depression 9 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
aspirin 34 99.18 Very High Very High Very High
Arthritis 43 97.84 Very High Very High Very High
metalloproteinase 1 96.88 Very High Very High Very High
cINOD 7 96.60 Very High Very High Very High
agonist 89 94.16 High High
adenocard 7 93.04 High High
cytokine 74 92.56 High High
Disease Link Frequency Relevance Heat
Depression 9 100.00 Very High Very High Very High
INFLAMMATION 153 99.76 Very High Very High Very High
Cancer 23 99.36 Very High Very High Very High
Shock 2 99.28 Very High Very High Very High
Apoptosis 2 99.00 Very High Very High Very High
Experimental Arthritis 21 97.84 Very High Very High Very High
Injury 25 97.72 Very High Very High Very High
Stress 7 97.16 Very High Very High Very High
Arthropathy 1 90.48 High High
Arthritis 32 87.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KA-induced increases of AP-1 and ENKCRE-2 DNA-binding activities were also attenuated by CHX.
Negative_regulation (attenuated) of Positive_regulation (increases) of AP-1
1) Confidence 0.37 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.06
In addition, KA-induced AP-1 and ENKCRE-2 DNA-binding activities were diminished by the antibodies against Fos and Jun family proteins.
Negative_regulation (diminished) of Positive_regulation (induced) of AP-1
2) Confidence 0.37 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.06
The increases of c-Fos, 35-kDa Fra and c-Jun protein levels induced by KA administration were also inhibited by CHX pre-administration.
Negative_regulation (inhibited) of Positive_regulation (induced) of c-Jun
3) Confidence 0.32 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.08
RESULTS: Cotransfection of c-Fos antibody significantly decreased glutamate-induced AP-1 activity.
Negative_regulation (decreased) of Positive_regulation (induced) of AP-1
4) Confidence 0.26 Published 2003 Journal Anesthesiology Section Body Doc Link 14508329 Disease Relevance 0.06 Pain Relevance 0
Therefore, these data suggest that melatonin has an inhibitory role in KA-induced gene expression, such as proENK and proDYN mRNA expression, and this may be due to a reduction of KA-induced AP-1 or ENKCRE-2 DNA binding activity.
Negative_regulation (reduction) of Positive_regulation (induced) of AP-1
5) Confidence 0.26 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.06
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen.
Negative_regulation (Inhibition) of Positive_regulation (activation) of AP-1 associated with cox2
6) Confidence 0.25 Published 2001 Journal FASEB J. Section Title Doc Link 11099482 Disease Relevance 0.31 Pain Relevance 0.67
Methylprednisolone inhibits Jun activation in ConA-stimulated lymph node cells
Negative_regulation (inhibits) of Positive_regulation (activation) of Jun in lymph node
7) Confidence 0.19 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.05
However, situation with JNK is not as clear, especially as in the same setting MP potently inhibited Jun activation.
Negative_regulation (inhibited) of Positive_regulation (activation) of Jun
8) Confidence 0.19 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.04
The blocking of protein synthesis by cycloheximide (CHX) evokes a further increase of C2 ceramide-induced proENK mRNA and phospho-CREB level, while C2 ceramide-induced increases of AP-1 protein levels were reduced by CHX.
Negative_regulation (reduced) of Positive_regulation (increases) of AP-1
9) Confidence 0.16 Published 2001 Journal Brain Res. Section Abstract Doc Link 11382404 Disease Relevance 0 Pain Relevance 0
This mechanism is consistent with the ability of retinoids to mediate most of their anti-inflammatory effects by reducing activation of the AP-1 (for a review, see [45]) or NF-IL-6 [44] pathways, although it remains to be confirmed in other cell types.


Negative_regulation (reducing) of Positive_regulation (activation) of AP-1 associated with inflammation
10) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.18 Pain Relevance 0.25
Prazosin reduced FCL(SD)-induced elevations of c-jun and c-fos, but not NGFI-A, mRNA.
Negative_regulation (reduced) of Positive_regulation (elevations) of c-jun associated with depression
11) Confidence 0.13 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11072104 Disease Relevance 0.61 Pain Relevance 0.68
In contrast, some studies have reported that aspirin exerts antitumor effects partly through blocking the induction of activator protein-1 (AP-1) activation by tumor promoters [59].
Negative_regulation (blocking) of Positive_regulation (induction) of AP-1 associated with aspirin and cancer
12) Confidence 0.12 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.67 Pain Relevance 0.21
Inhibition of c-jun activation increases the number of apoptotic sensory neurons after injury in the DRG [22].
Negative_regulation (Inhibition) of Positive_regulation (activation) of c-jun in sensory neurons associated with injury and apoptosis
13) Confidence 0.03 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.94 Pain Relevance 0
The chondroprotective effects were linked to a decreased activation of activator protein-1 in the joints, which is a transcription factor involved in the production of metalloproteinases.
Negative_regulation (decreased) of Positive_regulation (activation) of activator protein-1 in joints associated with metalloproteinase
14) Confidence 0.03 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2927688 Disease Relevance 0.99 Pain Relevance 1.06

General Comments

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