INT7039

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Context Info
Confidence 0.44
First Reported 1992
Last Reported 2007
Negated 2
Speculated 5
Reported most in Abstract
Documents 22
Total Number 27
Disease Relevance 10.51
Pain Relevance 20.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nkx1-1) neurological system process (Nkx1-1)
Anatomy Link Frequency
spinal 3
sciatic nerve 2
nerve 2
plasma 1
dorsal 1
Nkx1-1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 191 100.00 Very High Very High Very High
qutenza 166 100.00 Very High Very High Very High
antagonist 77 100.00 Very High Very High Very High
Pain 73 100.00 Very High Very High Very High
Calcitonin gene-related peptide 67 100.00 Very High Very High Very High
agonist 45 100.00 Very High Very High Very High
intrathecal 34 100.00 Very High Very High Very High
Neuropeptide 28 100.00 Very High Very High Very High
nociceptor 23 100.00 Very High Very High Very High
Hyperesthesia 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 1 100.00 Very High Very High Very High
Aging 1 100.00 Very High Very High Very High
INFLAMMATION 176 99.50 Very High Very High Very High
Nociception 60 99.08 Very High Very High Very High
Hyperalgesia 43 99.08 Very High Very High Very High
Pressure And Volume Under Development 30 99.04 Very High Very High Very High
Increased Venous Pressure Under Development 30 99.00 Very High Very High Very High
Neurogenic Inflammation 41 98.78 Very High Very High Very High
Colitis 6 98.28 Very High Very High Very High
Nervous System Injury 6 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury.
Regulation (Effect) of NK-1 in spinal cord associated with nervous system injury, aging, peripheral nerve injury, spinal cord and substance p
1) Confidence 0.44 Published 2001 Journal Somatosens Mot Res Section Title Doc Link 11327573 Disease Relevance 0.93 Pain Relevance 0.75
Effects of FK224, a novel cyclopeptide NK1 and NK2 antagonist, and CP-96,345, a nonpeptide NK1 antagonist, on development and maintenance of thermal hyperesthesia evoked by carrageenan injection in the rat paw.
Regulation (Effects) of NK1 in paw associated with hyperesthesia, antagonist and hyperaesthesia
2) Confidence 0.36 Published 1993 Journal Anesthesiology Section Title Doc Link 7694526 Disease Relevance 0.27 Pain Relevance 0.64
The NK1 receptor antagonist GR205171 at 3 mg kg(-1) blocked responses to NK1 agonist evoked activity and reversed the mechanical hypersensitivity following nerve ligation in behavioural assays.
Regulation (responses) of NK1 in nerve associated with antagonist, hypersensitivity and agonist
3) Confidence 0.36 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9886676 Disease Relevance 0.33 Pain Relevance 0.44
In both the VTA and NAS, the NK-1 and the NK-3 agonists caused significant analgesia in the formalin test, although the NK-1 agonist appeared to be more effective.
Regulation (effective) of NK-1 in NAS associated with nucleus accumbens, ventral tegmentum, agonist and analgesia
4) Confidence 0.30 Published 1997 Journal Behav. Brain Res. Section Abstract Doc Link 9475623 Disease Relevance 0.21 Pain Relevance 1.84
These findings suggest that NK1 receptor antagonists affect markedly the NA system via an attenuation of the function of alpha2-adrenoceptors on the cell body of NA neurons and, consequently, may also modulate 5-HT neurotransmission.
Regulation (affect) of NK1 in cell body associated with antagonist and noradrenaline
5) Confidence 0.30 Published 2000 Journal Neuroreport Section Abstract Doc Link 10817615 Disease Relevance 0 Pain Relevance 0.88
The present study aimed to determine the effect of the selective non-peptide rat neurokinin-1 (NK1) receptor antagonists WIN 51,708 and CP-96,345 on the firing activity of rat dorsal raphe serotonin (5-HT) and locus coeruleus noradrenaline (NA) neurons.
Spec (determine) Regulation (effect) of NK1 in dorsal associated with locus ceruleus, antagonist, noradrenaline, serotonin and raphe
6) Confidence 0.30 Published 2000 Journal Neuroreport Section Abstract Doc Link 10817615 Disease Relevance 0 Pain Relevance 0.75
Given the many pro-inflammatory effects of substance P, we have evaluated the effects of a tachykinin receptor (NK-1) antagonist, RP 67580, in models of acute colitis in the rat and guinea pig.
Regulation (effects) of NK-1 associated with colitis, inflammation, antagonist and substance p
7) Confidence 0.29 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9533813 Disease Relevance 0.89 Pain Relevance 0.51
We have examined the effect of a tachykinin NK1 and a bradykinin B2 antagonist, and a mu-opioid agonist on plasma extravasation observed in response to two differing nerve stimulating parameters (10 V, 1 ms, 2 Hz and 25 V, 2 ms, 10 Hz).
Spec (examined) Regulation (effect) of NK1 in nerve associated with mu agonist, antagonist and bradykinin
8) Confidence 0.29 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9857952 Disease Relevance 0.39 Pain Relevance 0.57
Leukocyte recruitment involves (1) up-regulation of adhesion molecule expression through neurokinin-1 (NK1) receptors on endothelial cells, (2) augmented chemokine production, or (3) chemotaxis through NK1 receptors on leukocytes.
Regulation (regulation) of NK1 in Leukocyte associated with chemokine and adhesions
9) Confidence 0.21 Published 2007 Journal Anesthesiology Section Abstract Doc Link 18043070 Disease Relevance 0.48 Pain Relevance 0.95
This study investigated changes in NK-1 and NK-3 receptor mRNA expression during nociception.
Spec (investigated) Regulation (changes) of NK-1 associated with nociception
10) Confidence 0.21 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8301359 Disease Relevance 0.34 Pain Relevance 0.61
The mechanisms by which NK-1 expressing neurons modulate the excitability of other dorsal horn neurons are unclear.
Regulation (modulate) of NK-1 in neurons associated with dorsal horn neuron
11) Confidence 0.18 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15456795 Disease Relevance 0.18 Pain Relevance 0.32
Effects of NK1 receptor antagonists on vasodilation induced by chemical and electrical activation of sensory C-fibre afferents in different organs.
Regulation (Effects) of NK1 associated with c fibre, antagonist and increased venous pressure under development
12) Confidence 0.17 Published 1994 Journal Acta Physiol. Scand. Section Title Doc Link 7530891 Disease Relevance 0.44 Pain Relevance 0.40
The aim of the present study was to investigate the modulatory role of NK1 and NK2 antagonists on edema formation, and on hindpaw withdrawal latency to experimentally asses nociception.
Spec (investigate) Regulation (role) of NK1 associated with nociception, pressure and volume under development, antagonist and withdrawal
13) Confidence 0.17 Published 1999 Journal Burns Section Abstract Doc Link 10208386 Disease Relevance 0.76 Pain Relevance 0.45
We examined the effects on both these phenomena of the selective NK1 and NK2 receptor antagonists, SR140333 and SR48968.
Spec (examined) Regulation (effects) of NK1 associated with antagonist
14) Confidence 0.16 Published 1998 Journal Fundam Clin Pharmacol Section Abstract Doc Link 9523190 Disease Relevance 0.23 Pain Relevance 0.18
This study reports experiments designed to evaluate the role of neurokinin-1 (NK1) receptors for substance P (SP) in the ventilatory response to acute hypoxia.
Regulation (role) of NK1 associated with hypoxia and substance p
15) Confidence 0.15 Published 1994 Journal J. Appl. Physiol. Section Abstract Doc Link 7519186 Disease Relevance 0.23 Pain Relevance 0.28
We evaluated the effect of intrathecal (i.t.) capsaicin (CAP) and the NK-1 selective non-peptidic antagonist, CP,96-345, on the thermal hyperalgesia ordinarily observed after unilateral partial ligation of the sciatic nerve in rats.
Regulation (effect) of NK-1 in sciatic nerve associated with qutenza, thermal hyperalgesia, antagonist, sciatic nerve and intrathecal
16) Confidence 0.13 Published 1992 Journal Pain Section Abstract Doc Link 1337198 Disease Relevance 0.26 Pain Relevance 1.00
Effects of intrathecal capsaicin and an NK-1 antagonist, CP,96-345, on the thermal hyperalgesia observed following unilateral constriction of the sciatic nerve in the rat.
Regulation (Effects) of NK-1 in sciatic nerve associated with qutenza, thermal hyperalgesia, antagonist, sciatic nerve and intrathecal
17) Confidence 0.13 Published 1992 Journal Pain Section Title Doc Link 1337198 Disease Relevance 0.44 Pain Relevance 1.94
NSIA was completely blocked by spinal intrathecal administration of the selective NMDA receptor antagonist LY235959 as well as the mGluR5 antagonists MPEP and SIB-1757 and partially attenuated by the selective AMPA/kainate receptor antagonist NBQX; however, neither the mGluR1 receptor antagonist LY367385 nor the NK1 antagonist L-703,606 affected NSIA.
Neg (neither) Regulation (affected) of NK1 in spinal associated with antinociception, nmda receptor antagonist, antagonist and intrathecal
18) Confidence 0.11 Published 2003 Journal Pain Section Abstract Doc Link 14581125 Disease Relevance 0 Pain Relevance 1.39
Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat.
Regulation (involvement) of NK1 in spinal associated with nociception, nociceptor and antagonist
19) Confidence 0.11 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 7682180 Disease Relevance 0.23 Pain Relevance 0.52
The role of neurokinin-1 (NK-1) receptors in the rostral ventromedial medulla (RVM) was studied using extracellular single-unit recording combined with microiontophoresis.
Regulation (role) of NK-1 in RVM associated with rostral ventromedial medulla
20) Confidence 0.11 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17182914 Disease Relevance 0 Pain Relevance 0.30

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