INT7040

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 43
Total Number 44
Disease Relevance 4.57
Pain Relevance 15.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
nerves 5
neurons 4
posterior pituitary 2
ventral 2
B cells 2
Vip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 194 100.00 Very High Very High Very High
Neuropeptide 99 100.00 Very High Very High Very High
substance P 61 100.00 Very High Very High Very High
Calcitonin gene-related peptide 57 100.00 Very High Very High Very High
Enkephalin 38 100.00 Very High Very High Very High
Kinase C 12 99.66 Very High Very High Very High
Opioid 18 99.24 Very High Very High Very High
headache 15 99.10 Very High Very High Very High
antinociception 8 98.96 Very High Very High Very High
bradykinin 1 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 13 99.40 Very High Very High Very High
Headache 13 99.10 Very High Very High Very High
Injury 3 98.92 Very High Very High Very High
Cluster Headache 1 98.20 Very High Very High Very High
Increased Venous Pressure Under Development 4 97.96 Very High Very High Very High
Natriuresis 1 97.28 Very High Very High Very High
INFLAMMATION 33 96.56 Very High Very High Very High
Immunization 4 95.76 Very High Very High Very High
Stress 2 94.68 High High
Hyperalgesia 5 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that VIP/PACAPs and NO strongly interact as an inhibitory mediator on duodenal motility, but that their modes of action in doing so may differ.
VIP Binding (interact) of
1) Confidence 0.48 Published 1999 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 10354348 Disease Relevance 0 Pain Relevance 0.24
Specific binding of vasoactive intestinal peptide (VIP) to epithelial cell membranes of rat ventral prostate was reversible, saturable and dependent on time and temperature.
VIP Binding (binding) of in ventral
2) Confidence 0.39 Published 1985 Journal Gen. Pharmacol. Section Abstract Doc Link 2996970 Disease Relevance 0 Pain Relevance 0.11
Specific binding of vasoactive intestinal peptide (VIP) to epithelial cell membranes of rat ventral prostate was reversible, saturable and dependent on time and temperature.
vasoactive intestinal peptide Binding (binding) of in ventral
3) Confidence 0.39 Published 1985 Journal Gen. Pharmacol. Section Abstract Doc Link 2996970 Disease Relevance 0 Pain Relevance 0.11
The objectives were to determine whether PRF from the posterior pituitary regulates the proestrous PRL surge, and to examine if there are interactions between PRF and vasoactive intestinal peptide (VIP).
vasoactive intestinal peptide Binding (interactions) of in posterior pituitary
4) Confidence 0.37 Published 1989 Journal Endocrinology Section Abstract Doc Link 2492217 Disease Relevance 0.10 Pain Relevance 0.13
The objectives were to determine whether PRF from the posterior pituitary regulates the proestrous PRL surge, and to examine if there are interactions between PRF and vasoactive intestinal peptide (VIP).
VIP Binding (interactions) of in posterior pituitary
5) Confidence 0.37 Published 1989 Journal Endocrinology Section Abstract Doc Link 2492217 Disease Relevance 0.10 Pain Relevance 0.13
The presence of VIP-IR and headache were treated as binary variables and associations tested with chi-square tests.
VIP Binding (associations) of
6) Confidence 0.35 Published 2005 Journal Acta Neurol. Scand. Section Body Doc Link 15819711 Disease Relevance 0.16 Pain Relevance 0
Interaction between neurokinin A, VIP, prostanoids, and enteric nerves in regulation of duodenal function.
VIP Binding (Interaction) of in enteric nerves
7) Confidence 0.34 Published 1998 Journal Am. J. Physiol. Section Title Doc Link 9655689 Disease Relevance 0 Pain Relevance 0.22
Using a porcine VIP-thyroglobulin conjugate as antigen, a peptide-specific antiserum was generated in a rabbit which bound porcine VIP with a Kd of 5.1 X 10(-11) M and a maximum binding capacity of 1830 ng/ml.
VIP Binding (bound) of
8) Confidence 0.34 Published 1985 Journal Endocrinology Section Abstract Doc Link 4038645 Disease Relevance 0.16 Pain Relevance 0.11
Since SP and VIP both coexist with CGRP in separate populations of primary afferents, the interaction between SP plus CGRP and VIP plus CGRP was tested in animals with intact and sectioned nerves.
VIP Binding (interaction) of in nerves associated with calcitonin gene-related peptide and substance p
9) Confidence 0.34 Published 1989 Journal Brain Res. Section Abstract Doc Link 2472853 Disease Relevance 0.06 Pain Relevance 1.19
VIP binding to epithelial cell membranes of rat ventral prostate: effect of guanine nucleotides.
VIP Binding (binding) of in epithelial cell
10) Confidence 0.33 Published 1985 Journal Gen. Pharmacol. Section Title Doc Link 2996970 Disease Relevance 0 Pain Relevance 0.14
Fluorescent liposomes internalized by macrophages in the conjunctiva still contained VIP 24 h following IVT injection of VIP-Rh-Lip, (Figure 3G), but VIP was not detected in conjunctival macrophages after IVT injection of Rh-Lip alone (data not shown).
VIP-Rh-Lip Binding (injection) of in macrophages
11) Confidence 0.32 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.11 Pain Relevance 0.05
No difference was noted regarding the nature of the cells internalizing liposomes and the cellular interactions with B cells and T cells in the LN in rats receiving Rh-Lip and VIP-Rh-Lip, respectively.


VIP-Rh-Lip Binding (receiving) of in B cells
12) Confidence 0.32 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
Internalization of VIP-Rh-Lip by macrophages in the cervical LN in vivo could alter and modify their function from inflammatory macrophages to regulatory macrophages.
VIP-Rh-Lip Binding (Internalization) of in Lip associated with inflammation
13) Confidence 0.32 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.10 Pain Relevance 0.05
No difference was noted regarding the nature of the cells internalizing liposomes and the cellular interactions with B cells and T cells in the LN in rats receiving Rh-Lip and VIP-Rh-Lip, respectively.


VIP-Rh-Lip Binding (interactions) of in B cells
14) Confidence 0.32 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
In animals with sectioned nerves, SP and CGRP did not interact, whereas VIP and CGRP had a stronger facilitatory interaction.
VIP Binding (interaction) of in nerves associated with calcitonin gene-related peptide and substance p
15) Confidence 0.32 Published 1989 Journal Brain Res. Section Abstract Doc Link 2472853 Disease Relevance 0 Pain Relevance 1.10
In animals with intact nerves, SP and CGRP had a strong synergistic effect, whereas VIP and CGRP had a weak facilitatory interaction.
VIP Binding (interaction) of in nerves associated with calcitonin gene-related peptide and substance p
16) Confidence 0.32 Published 1989 Journal Brain Res. Section Abstract Doc Link 2472853 Disease Relevance 0.05 Pain Relevance 1.18
Thus, PACAP and VIP are potential mediators of cross-excitation in the TG.
VIP Binding (cross-excitation) of
17) Confidence 0.31 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12225867 Disease Relevance 0.46 Pain Relevance 0.35
In the sublingual + submandibular glands, Evans blue increased in response to neurokinin A and pilocarpine; furthermore, substance P and VIP, and substance P and CGRP, interacted positively.
VIP Binding (interacted) of in submandibular glands associated with calcitonin gene-related peptide and substance p
18) Confidence 0.31 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9809804 Disease Relevance 0.16 Pain Relevance 0.66
The principle of the assay is based on the competition between biotinylated VIP and non-biotinylated peptide (either standard or unknown) to bind on anti-VIP antibody that recognizes 28-aa VIP.
VIP Binding (recognizes) of
19) Confidence 0.31 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
The principle of the assay is based on the competition between biotinylated VIP and non-biotinylated peptide (either standard or unknown) to bind on anti-VIP antibody that recognizes 28-aa VIP.
VIP Binding (bind) of
20) Confidence 0.31 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0

General Comments

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