INT70420

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Context Info
Confidence 0.30
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.26
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACOT1) lipid metabolic process (ACOT1) cytoplasm (ACOT1)
Anatomy Link Frequency
neuronal 6
bladder 4
spinal cord dorsal horn 4
endothelial cells 2
nerve 2
ACOT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
analgesia 16 100.00 Very High Very High Very High
Opioid 6 99.98 Very High Very High Very High
Spinal cord 2 99.84 Very High Very High Very High
Dorsal horn 2 99.36 Very High Very High Very High
Neurotransmitter 7 98.48 Very High Very High Very High
intrathecal 8 97.04 Very High Very High Very High
tetrodotoxin 5 94.00 High High
agonist 28 83.52 Quite High
rapifen 20 76.96 Quite High
Bioavailability 10 76.20 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 30 99.80 Very High Very High Very High
Helminth Infection 22 95.84 Very High Very High Very High
Stress 3 93.36 High High
Pulmonary Disease 96 91.12 High High
Dilated Cardiomyopathy 40 76.64 Quite High
Left Ventricular Dysfunction 1 74.64 Quite High
Overactive Bladder 4 70.44 Quite High
Glaucoma 4 69.52 Quite High
Xerostomia 6 69.12 Quite High
Increased Venous Pressure Under Development 7 52.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, any flow-induced release of endogenous ACh from the endothelial cells may, at least in part, contribute to the sustained elevation of plasma NO concentration.
Positive_regulation (induced) of Localization (release) of ACh in endothelial cells
1) Confidence 0.30 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2995954 Disease Relevance 0.39 Pain Relevance 0.04
Drugs block M2, increasing Ach release, and thus increasing bronchoconstrictor responses.
Positive_regulation (increasing) of Localization (release) of Ach
2) Confidence 0.22 Published 2009 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2684714 Disease Relevance 0.34 Pain Relevance 0.11
Intravenous opioids cause analgesia and increase release of ACh in spinal cord dorsal horn in animals, and these effects are enhanced by intrathecal neostigmine injection.
Positive_regulation (increase) of Localization (release) of ACh in spinal cord dorsal horn associated with dorsal horn, opioid, intrathecal, spinal cord and analgesia
3) Confidence 0.20 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9223543 Disease Relevance 0 Pain Relevance 0.76
Intravenous opioids cause analgesia and increase release of ACh in spinal cord dorsal horn in animals, and these effects are enhanced by intrathecal neostigmine injection.
Positive_regulation (cause) of Localization (release) of ACh in spinal cord dorsal horn associated with dorsal horn, opioid, intrathecal, spinal cord and analgesia
4) Confidence 0.20 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9223543 Disease Relevance 0 Pain Relevance 0.76
There was significant age-related and stretch-induced increase in non-neuronal ACh release.
Positive_regulation (increase) of Localization (release) of ACh in neuronal
5) Confidence 0.19 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18285653 Disease Relevance 0 Pain Relevance 0.08
The stretch-induced release of non-neuronal ACh was increased with age.
Positive_regulation (increased) of Localization (release) of ACh in neuronal
6) Confidence 0.19 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18285653 Disease Relevance 0 Pain Relevance 0.09
The non-neuronal ACh release was increased with age.
Positive_regulation (increased) of Localization (release) of ACh in neuronal
7) Confidence 0.19 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18285653 Disease Relevance 0 Pain Relevance 0.09
Stretch of bladder strips caused increases in non-neuronal ACh release.
Positive_regulation (increases) of Localization (release) of ACh in bladder
8) Confidence 0.19 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18285653 Disease Relevance 0 Pain Relevance 0.09
Our data demonstrate that there is a non-neuronal cholinergic system in human bladder and that urothelium contributes to non-neuronal ACh release.
Positive_regulation (contributes) of Localization (release) of ACh in bladder
9) Confidence 0.19 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18285653 Disease Relevance 0 Pain Relevance 0.08
Ipratropium bromide and oxitropium bromide are nonselective blockers; consequently, they block M2 receptors, thereby increasing Ach release at nerve endings, which may reduce the degree of blockade or the duration of action [4].
Positive_regulation (increasing) of Localization (release) of Ach in nerve
10) Confidence 0.19 Published 2009 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2684714 Disease Relevance 0.28 Pain Relevance 0.06
Loss of slo-1 function causes prolonged ACh release and hypersensitivity to aldicarb [37].
Positive_regulation (causes) of Localization (release) of ACh associated with hypersensitivity
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860991 Disease Relevance 0.25 Pain Relevance 0.09

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