INT7044

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 3.50
Pain Relevance 10.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
medulla 6
5-HT neurons 4
dorsal 2
spinal 2
nerve 2
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 48 99.84 Very High Very High Very High
antiallodynic 4 99.84 Very High Very High Very High
Antinociceptive 2 99.84 Very High Very High Very High
Serotonin 41 99.62 Very High Very High Very High
Glutamate 26 99.58 Very High Very High Very High
Morphine 8 99.46 Very High Very High Very High
medulla 60 99.34 Very High Very High Very High
fluoxetine 41 99.04 Very High Very High Very High
Raphe 11 98.92 Very High Very High Very High
Central grey 4 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 98.40 Very High Very High Very High
Anxiety Disorder 7 95.16 Very High Very High Very High
Nociception 7 92.08 High High
Heart Rate Under Development 111 91.92 High High
Panic Disorder 1 90.64 High High
Morphine Dependence 1 90.56 High High
Affective Disorder 3 88.80 High High
Headache 2 88.04 High High
Body Weight 3 84.36 Quite High
Neuropathic Pain 7 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From the data obtained in this study, it is suggested that increased 5-HT transmission produced by fluoxetine during chronic administration seems to be crucial for the appetite-regulating action of 5-HT, and this hypophagic effect does not seem to be dependent on the activation of 5-HT1A receptors since it was not shared by gepirone.
Positive_regulation (dependent) of Positive_regulation (activation) of 5-HT1A associated with fluoxetine
1) Confidence 0.67 Published 2003 Journal Neuropsychobiology Section Abstract Doc Link 12707493 Disease Relevance 0.24 Pain Relevance 0.41
These modifications of 5-HT neurons lead to an increased tonic activation of postsynaptic 5-HT1A receptors.
Positive_regulation (increased) of Positive_regulation (activation) of 5-HT1A in 5-HT neurons
2) Confidence 0.67 Published 1998 Journal J Affect Disord Section Abstract Doc Link 10333981 Disease Relevance 0 Pain Relevance 0.46
Activation of the spinal 5-HT1A receptor induced an antinociceptive effect in the increasing temperature hot-plate test and produced a dose dependent decrease in NMDA-receptor mediated behaviour.
Positive_regulation (induced) of Positive_regulation (Activation) of 5-HT1A in spinal associated with antinociceptive
3) Confidence 0.49 Published 1992 Journal Neuroreport Section Abstract Doc Link 1337283 Disease Relevance 0.42 Pain Relevance 0.26
Role of ionotropic GABAergic and glycinergic neurotransmission within regions of the medulla containing CVPN in the cardio-vagal responses to 5-HT1A receptor activation
Positive_regulation (responses) of Positive_regulation (activation) of 5-HT1A in medulla associated with medulla and gabaergic
4) Confidence 0.49 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2964734 Disease Relevance 0.41 Pain Relevance 0.44
Effects of fluoxetine and buspirone on the panicolytic-like response induced by the activation of 5-HT1A and 5-HT2A receptors in the rat dorsal periaqueductal gray.
Positive_regulation (induced) of Positive_regulation (activation) of 5-HT1A in dorsal associated with central grey and fluoxetine
5) Confidence 0.49 Published 2006 Journal Psychopharmacology (Berl.) Section Title Doc Link 16258751 Disease Relevance 0.38 Pain Relevance 0.33
That is, in contrast with morphine, the antiallodynic effect induced by 5-HT1A receptor activation does not decay, but, if anything, grows with chronicity.
Positive_regulation (induced) of Positive_regulation (activation) of 5-HT1A associated with antiallodynic and morphine
6) Confidence 0.49 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12730352 Disease Relevance 0.70 Pain Relevance 1.44
To assess this hypothesis, we tested the effects of either (i). a near-total 5,7-dihydroxytryptamine-induced lesion (90% depletion) or (ii). an acute serotonin (5-HT) inhibition induced by the specific stimulation of 5-HT1A autoreceptors (8-OHDPAT 5-100 microg/kg), on naloxone-induced conditioned place aversion in morphine-dependent rats.
Positive_regulation (induced) of Positive_regulation (stimulation) of 5-HT1A associated with narcan, serotonin and morphine
7) Confidence 0.49 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12589380 Disease Relevance 0.09 Pain Relevance 1.12
It is concluded that 5-HT via activation of 5-HT1A, 5-HT2A, 5-HT2C and possibly also 5-HT1B receptors increases the synthesis of CRH in the PVN and POMC in the anterior pituitary lobe, which results in increased ACTH secretion.
Spec (possibly) Positive_regulation (increases) of Spec (possibly) Positive_regulation (activation) of 5-HT1A in lobe
8) Confidence 0.49 Published 2002 Journal J. Neuroendocrinol. Section Abstract Doc Link 12372003 Disease Relevance 0 Pain Relevance 0.31
The results obtained indicate that: (a) activation of 5-HT1A receptors stimulated PRL secretion on day 16 and inhibited it on day 23; activation of 5-HT2 receptors stimulated PRL secretion on days 16 and 23, whereas activation of 5-HT3 receptors inhibited PRL release only on day 23; (b) activation of AMPA receptors inhibited PRL secretion on day 23, but not on day 16 and (c) a cross-talk is apparent between 5-HT2 and AMPA receptors in the regulation of PRL secretion, the stimulatory effect of DOI being blocked by AMPA.
Positive_regulation (stimulated) of Positive_regulation (activation) of 5-HT1A
9) Confidence 0.49 Published 2001 Journal J. Physiol. Biochem. Section Abstract Doc Link 11800286 Disease Relevance 0 Pain Relevance 0.47
It is hypothesized that the delayed maximal increase in extracellular 5-HT contents after fluoxetine treatment, due to negative feedback regulations induced by the activation of 5-HT1A and 5-HT1B autoreceptors, is not the primary cause for the delayed normalization of corticosteroid receptor numbers that regulates the HPA axis functioning.
Positive_regulation (induced) of Positive_regulation (activation) of 5-HT1A associated with corticosteroid and fluoxetine
10) Confidence 0.49 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10929085 Disease Relevance 0 Pain Relevance 0.67
The results support earlier evidence that serum corticosterone concentration in rats can be increased by activation of either 5-HT1A or 5-HT2 receptors.
Positive_regulation (increased) of Positive_regulation (activation) of 5-HT1A
11) Confidence 0.49 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2148812 Disease Relevance 0 Pain Relevance 0.68
Selective activation of 5HT1A receptors induces lower lip retraction in the rat.
Positive_regulation (induces) of Positive_regulation (activation) of 5HT1A in lower lip
12) Confidence 0.49 Published 1989 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 2533357 Disease Relevance 0 Pain Relevance 0.45
These results suggest that extracellular 5-HT in raphe nuclei originates from a cytoplasmic pool and is not dependent on either nerve impulse of 5-HT neurons or local activation of 5-HT1A receptors.
Neg (not) Positive_regulation (dependent) of Positive_regulation (activation) of 5-HT1A in nerve associated with raphe
13) Confidence 0.49 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 7682600 Disease Relevance 0 Pain Relevance 0.55
It is suggested that presynaptic 5-HT1D receptors mediate inhibition directly of glutamate release and indirectly of the cGMP responses to the released glutamate; on the other hand, activation of (postsynaptic) 5-HT1A receptors causes inhibition of the cGMP responses linked to stimulation of NMDA/AMPA receptors.
Positive_regulation (causes) of Positive_regulation (activation) of 5-HT1A associated with glutamate
14) Confidence 0.49 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8522955 Disease Relevance 0 Pain Relevance 0.50
Although the results suggest that selective stimulation of 5-HT1A and 5-HT2A receptors produces a decrease of USV, we postulate that only 5-HT2A receptors play a pivotal role in the effects of SSRIs in this model of anxiety.
Positive_regulation (produces) of Positive_regulation (stimulation) of 5-HT1A associated with anxiety disorder and ssri
15) Confidence 0.49 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9539263 Disease Relevance 0.38 Pain Relevance 0.36
In conclusion, these data suggest that when the firing activity of 5-HT neurons is normal in the presence of befloxatone, either after a two-day treatment together with (-)-pindolol or alone for 21 days, the tonic activation of postsynaptic 5-HT1A receptors is enhanced.
Positive_regulation (enhanced) of Positive_regulation (activation) of 5-HT1A in 5-HT neurons
16) Confidence 0.49 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9570466 Disease Relevance 0 Pain Relevance 0.30
Role of GABAergic and glycinergic neurotransmission in regions of the medulla containing CVPN in cardio-vagal responses to 5-HT1A receptor activation
Positive_regulation (responses) of Positive_regulation (activation) of 5-HT1A in medulla associated with medulla and gabaergic
17) Confidence 0.49 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2964734 Disease Relevance 0 Pain Relevance 0.31
The effect of buspirone is thought to be via enhancement of the activation of postsynaptic 5-HT1A receptors in the presence of 5-HT1A autoreceptors, which have already been desensitized by the antidepressant.


Positive_regulation (enhancement) of Positive_regulation (activation) of 5-HT1A associated with antidepressant
18) Confidence 0.45 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2424118 Disease Relevance 0.45 Pain Relevance 0.43
Indeed, it is now well established that the latter results from an increased stimulation of 5-HT1A inhibitory autoreceptors, which itself is consecutive to the strong elevation of extracellular 5-HT levels that follows 5-HT reuptake blockade in the somatodendritic area [17]–[18], [20].
Positive_regulation (increased) of Positive_regulation (stimulation) of 5-HT1A
19) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.20
Whether or not the effects of 5-HT1A activation on HR or BRS are mediated by GABAergic and/or glycinergic inhibition of CVPN in the ventrolateral medulla has not been investigated in vivo.
Positive_regulation (mediated) of Positive_regulation (activation) of 5-HT1A in medulla associated with medulla and gabaergic
20) Confidence 0.45 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2964734 Disease Relevance 0.43 Pain Relevance 0.31

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