INT70445

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.38
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KRT1) cytoskeleton (KRT1)
Anatomy Link Frequency
filaments 1
skin 1
internal 1
A549 1
appendix 1
KRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 18 93.28 High High
headache 10 92.24 High High
methotrexate 3 86.16 High High
vincristine 1 82.08 Quite High
abdominal pain 4 54.08 Quite High
positron emission tomography 3 53.12 Quite High
Bile 11 51.52 Quite High
Chronic pancreatitis 6 45.52 Quite Low
Inflammation 13 36.48 Quite Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 244 100.00 Very High Very High Very High
Reprotox - General 1 8 99.64 Very High Very High Very High
Epidermolytic Hyperkeratosis 6 98.80 Very High Very High Very High
False Aneurysm 2 97.60 Very High Very High Very High
Pseudomyxoma Peritonei 44 96.52 Very High Very High Very High
Cyst 12 95.12 Very High Very High Very High
Targeted Disruption 38 94.56 High High
Blister 4 94.24 High High
Cv General 4 Under Development 3 93.28 High High
Metastasis 44 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a whole-cell assay and nuclear and cytosolic radiobinding experiments with [3H]estradiol as tracer, we have found that SK-LU1, SW900, ChaGo-K-1, H441, H661, and A549 cells, as well as primary tumors, bind estrogen specifically.
K-1 Binding (bind) of in A549 associated with cancer
1) Confidence 0.35 Published 1997 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 9224209 Disease Relevance 0.63 Pain Relevance 0
The importance for epidermal integrity is underscored by the fact that point mutations in K1 and K10 are associated with the blistering disorder epidermolytic hyperkeratosis/bullous congenital ichthyosiform erythroderma (BCIE), initially presenting with skin blisters but later with thickened ichthyotic skin (for reviews, see Lane and McLean 2004; Omary et al. 2004).
K1 Binding (associated) of in skin associated with blister and epidermolytic hyperkeratosis
2) Confidence 0.31 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.40 Pain Relevance 0
Despite their association with terminal epidermal differentiation and keratinization, K1 and K10 may be focally expressed in suprabasal cells of internal noncornifying stratified squamous epithelia (for references, see Moll 1998).
K1 Binding (association) of in internal
3) Confidence 0.31 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.51 Pain Relevance 0
Immunohistochemistry revealed a strong immunoreactivity for cytokeratin, vimentin and CK5.
cytokeratin Binding (immunoreactivity) of
4) Confidence 0.15 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC3016302 Disease Relevance 1.18 Pain Relevance 0.08
Metastatic choriocarcinoma was accidentally found with positive immunohistochemical staining of cytokeratin and beta subunit of human chorionic gonadotropin (beta-HCG).
cytokeratin Binding (found) of associated with reprotox - general 1
5) Confidence 0.13 Published 2007 Journal Int. J. Gynecol. Cancer Section Abstract Doc Link 17425677 Disease Relevance 1.23 Pain Relevance 0.39
While most desmoplakins associate with cytokeratin filaments, exceptions have been found, including the arachnoid cells that anchor vimentin intermediate filaments at these plaques.
cytokeratin Binding (associate) of in filaments
6) Confidence 0.06 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.12 Pain Relevance 0
Additionally, a subpopulation of cells in second passage cultures was immunoreactive to the anti-human cytokeratin antibody (AE1/AE3), which recognizes a wide range of human cytokeratins (Moll's designation 1–8, 10, 13–16, 19) [26].
cytokeratin Binding (recognizes) of
7) Confidence 0.05 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.06 Pain Relevance 0
However, cytokeratin positive cells within the arachnoid have been recognized in limited cases [50,51].
cytokeratin Binding (recognized) of
8) Confidence 0.04 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.08 Pain Relevance 0
We also investigated the association of oocytes with cytokeratin positive epithelial nests in ovarian cortex by double color immunohistochemistry, and the expression of SE/oocyte shared ZP proteins and mitogen activated protein kinases in putative germ cells.
cytokeratin Binding (association) of in oocyte
9) Confidence 0.02 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC420494 Disease Relevance 0.09 Pain Relevance 0
While this cytokeratin is more commonly associated with ovarian malignancies, previous immunohistochemical studies have shown that although tumors derived from the appendix in general are negative for CK7; in some cases, appendiceal adenomas and derived peritoneal lesions may be CK7 positive [1,2,13].
cytokeratin Binding (associated) of in appendix associated with adenoma and cancer
10) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1920528 Disease Relevance 1.06 Pain Relevance 0

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