INT70450

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.72
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KRT5) mitochondrion (KRT5) cytoplasm (KRT5)
Anatomy Link Frequency
keratinocytes 1
lung 1
KRT5 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 4 54.08 Quite High
Bile 12 52.96 Quite High
Chronic pancreatitis 7 46.96 Quite Low
Inflammation 19 37.92 Quite Low
Potency 3 31.76 Quite Low
Analgesic 1 25.00 Low Low
medulla 21 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mesothelioma 20 99.68 Very High Very High Very High
Malignant Neoplastic Disease 35 99.12 Very High Very High Very High
Cancer 275 98.60 Very High Very High Very High
Skin Cancer 87 98.00 Very High Very High Very High
Small Cell Lung Cancer 3 95.68 Very High Very High Very High
Lung Cancer 24 95.44 Very High Very High Very High
Cyst 9 95.12 Very High Very High Very High
Nasopharynx Cancer 6 94.88 High High
Adenocarcinoma 142 93.76 High High
Ocular Toxicity (including Many Sub-types) 1 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, however, ([neither] of these proteins bound in vitro to EBS1 or EBS2).
EBS2 Binding (bound) of
1) Confidence 0.47 Published 2008 Journal BMC Bioinformatics Section Body Doc Link PMC2586758 Disease Relevance 0.68 Pain Relevance 0
Immunohistochemistry revealed a strong immunoreactivity for cytokeratin, vimentin and CK5.
CK5 Binding (immunoreactivity) of
2) Confidence 0.25 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC3016302 Disease Relevance 1.19 Pain Relevance 0.08
The best performance on paraffin sections is displayed by MAb D5/16B4 (Lobeck et al. 1989; Demirkesen et al. 1995) which—although being often regarded as “K5/K6 antibody”—specifically recognizes K5 (Böcker et al. 2002).
K5 Binding (recognizes) of
3) Confidence 0.23 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.84 Pain Relevance 0
Thus, K5 immunostaining allows the distinction of the small cell type of squamous cell carcinoma of the lung, which is K5+, from a small cell carcinoma or a poorly differentiated adenocarcinoma, both of which are K5?
K5 Binding (immunostaining) of in lung associated with adenocarcinoma, small cell lung cancer and skin cancer
4) Confidence 0.17 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.67 Pain Relevance 0
K5/K14: major keratins of basal keratinocytes
K5 Binding (keratins) of in keratinocytes
5) Confidence 0.17 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.77 Pain Relevance 0
It has been shown that tamoxifen and flavonoids, a widely distributed class of natural substances with a variety of biologic actions, bind to type II EBS and inhibit the growth of several tumor cell types.
type II EBS Binding (bind) of associated with cancer
6) Confidence 0.02 Published 1997 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 9224209 Disease Relevance 0.57 Pain Relevance 0

General Comments

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