INT70474

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.27
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1F) signal transducer activity (HTR1F)
Anatomy Link Frequency
vasculature 1
neurons 1
brain 1
vesicle 1
Dorsal root ganglion 1
HTR1F (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 2 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
dorsal root ganglion 2 99.54 Very High Very High Very High
trigeminal ganglion 2 99.08 Very High Very High Very High
Migraine 13 99.04 Very High Very High Very High
Trigeminal ganglion neurons 1 98.84 Very High Very High Very High
Inflammation 6 98.20 Very High Very High Very High
medulla 4 97.96 Very High Very High Very High
Potency 2 97.76 Very High Very High Very High
Spinal cord 4 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 99.54 Very High Very High Very High
Headache 13 99.04 Very High Very High Very High
Neurogenic Inflammation 3 98.20 Very High Very High Very High
Nociception 2 91.60 High High
INFLAMMATION 2 78.32 Quite High
Urological Neuroanatomy 5 57.92 Quite High
Pain 3 5.00 Very Low Very Low Very Low
Cluster Headache 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report on the autoradiographic distribution of 5-HT1B, 5-HT1D and 5-HT1F receptor subtypes in human brain, focusing on the brainstem and cervical spinal cord.
Transcription (distribution) of 5-HT1F in brain associated with medulla and spinal cord
1) Confidence 0.67 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225278 Disease Relevance 0.06 Pain Relevance 0.65
Dorsal root ganglion cells also moderately expressed the 5-HT1F transcripts.
Transcription (expressed) of 5-HT1F in Dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.52 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225282 Disease Relevance 0.38 Pain Relevance 0.47
In situ hybridization studies in guinea pig tissue revealed 5-HT1F receptor mRNA expression in the neurons of the trigeminal ganglion, suggesting that the 5-HT1F receptor may play a role in the presynaptic inhibition of neuropeptide release at the level of the intracranial vasculature, thereby blocking the development of neurogenic inflammation.
Transcription (expression) of 5-HT1F in vasculature associated with ganglion cysts, inflammation, trigeminal ganglion, neurogenic inflammation and neuropeptide release
3) Confidence 0.52 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225282 Disease Relevance 0.39 Pain Relevance 0.50
In situ hybridization demonstrated 5-HT1F receptor mRNA in guinea pig trigeminal ganglion neurons.
Transcription (demonstrated) of 5-HT1F in neurons associated with ganglion cysts and trigeminal ganglion neurons
4) Confidence 0.52 Published 1997 Journal Neuroreport Section Abstract Doc Link 9243618 Disease Relevance 0.44 Pain Relevance 0.70
Expression of 5-HT1F and 5-HT2A receptor mRNAs was never detected in any of the microvascular cell cultures.
Transcription (detected) of 5-HT1F
5) Confidence 0.52 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0.15
Expression of 5-HT1F and 5-HT2A receptor mRNAs was never detected in any of the microvascular cell cultures.
Transcription (Expression) of 5-HT1F
6) Confidence 0.52 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0.14
We found expression of vesicle fusion and motility genes, ligand- and voltage-gated ion channels, receptor kinases and phosphatases, and, most interestingly, mRNA as well as protein expression of G protein-coupled receptors of neuromediators (corticotropin-releasing hormone 1 [CRH 1] and CRH 2 receptors, orexin/hypocretin 1 and 2 receptors, GABAB receptor, adenosine A(2)B receptor, opioid kappa 1 and mu 1 receptors, and 5-HT 1F receptor).
Spec (found) Transcription (found) of 5-HT 1F in vesicle associated with adenocard and opioid
7) Confidence 0.29 Published 2004 Journal Blood Section Abstract Doc Link 15016651 Disease Relevance 0 Pain Relevance 0.18

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