INT70481

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Context Info
Confidence 0.60
First Reported 1997
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.55
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1F) signal transducer activity (HTR1F)
HTR1F (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 31 99.20 Very High Very High Very High
antagonist 1 98.72 Very High Very High Very High
Sumatriptan 4 96.96 Very High Very High Very High
headache 1 96.40 Very High Very High Very High
agonist 5 93.24 High High
Pain 6 85.24 High High
Serotonin 9 84.16 Quite High
fifth nerve 1 76.92 Quite High
Inflammation 4 56.80 Quite High
trigeminal ganglion 2 55.20 Quite High
Disease Link Frequency Relevance Heat
Migraine Disorders 26 99.20 Very High Very High Very High
Headache 5 99.12 Very High Very High Very High
Pain 6 85.24 High High
INFLAMMATION 3 56.80 Quite High
Ganglion Cysts 3 55.20 Quite High
Increased Venous Pressure Under Development 1 52.24 Quite High
Nociception 1 25.00 Low Low
Depression 1 25.00 Low Low
Neurogenic Inflammation 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, agents that modulate 5-HT1B, 5-HT1D, 5-HT1F and 5-HT2B receptors either have or may have clinical utility in the therapy of migraine headache.
Regulation (modulate) of 5-HT1F associated with migraine and headache
1) Confidence 0.60 Published 1998 Journal Prog Drug Res Section Abstract Doc Link 9949863 Disease Relevance 1.20 Pain Relevance 1.61
The anti-migraine compound, sumatriptan, has been shown to have substantial affinity for the cloned human 5-HT1F receptor suggesting that, in addition to 5-HT1B/5-HT1D receptor subtypes, the 5-HT1F receptor may be a therapeutic target for the treatment of migraine.
Regulation (target) of 5-HT1F associated with sumatriptan and migraine
2) Confidence 0.26 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225282 Disease Relevance 0.35 Pain Relevance 0.49

General Comments

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