INT70503

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2011
Negated 7
Speculated 29
Reported most in Abstract
Documents 71
Total Number 101
Disease Relevance 44.00
Pain Relevance 24.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 10
osteoclast 6
smooth muscle cells 6
liver 6
nucleus 4
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 639 100.00 Very High Very High Very High
cytokine 244 100.00 Very High Very High Very High
cINOD 63 100.00 Very High Very High Very High
agonist 57 100.00 Very High Very High Very High
Snapping jaw 29 100.00 Very High Very High Very High
dexamethasone 27 100.00 Very High Very High Very High
local anesthetic 10 100.00 Very High Very High Very High
Cannabinoid receptor 2 100.00 Very High Very High Very High
aspirin 47 99.98 Very High Very High Very High
Paracetamol 69 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 775 100.00 Very High Very High Very High
Diabetes Mellitus 646 100.00 Very High Very High Very High
Injury 232 100.00 Very High Very High Very High
Cancer 36 100.00 Very High Very High Very High
Necrosis 31 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 29 100.00 Very High Very High Very High
Nociception 11 99.98 Very High Very High Very High
Disease 210 99.96 Very High Very High Very High
Sprains And Strains 145 99.96 Very High Very High Very High
Cataract 91 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to investigate the peripheral influences of US and phonophoresis on the modulation of spinal inducible nitric oxide synthase (iNOS) expression elicited by hind paw stimulation with an ankle injection of complete Freund adjuvant (CFA).
Spec (investigate) Regulation (modulation) of Gene_expression (expression) of iNOS in ankle associated with freund adjuvant
1) Confidence 0.62 Published 2006 Journal Phys Ther Section Abstract Doc Link 16386061 Disease Relevance 0.33 Pain Relevance 0.34
The authors tested the effects of four local anesthetics on the expression of NOS2 in immunostimulated rat C6 glioma cells.
Regulation (effects) of Gene_expression (expression) of NOS2 associated with glioma and local anesthetic
2) Confidence 0.62 Published 2001 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 11294465 Disease Relevance 0.29 Pain Relevance 0.44
Therefore, it may be useful in clarifying the biological role of iNOS expression on Barrett's esophagus-associated adenocarcinoma to study the effect of iNOS inhibitor on animal esophageal adenocarcinoma model.
Regulation (role) of Gene_expression (expression) of iNOS in esophagus associated with adenocarcinoma
3) Confidence 0.61 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808576 Disease Relevance 0.89 Pain Relevance 0.03
Dexamethasone decreased cytokine-induced NF-kappaB activation and iNOS mRNA expression, but neither salicylate nor aspirin affected NF-kappaB activation or iNOS mRNA expression.
Neg (neither) Regulation (affected) of Gene_expression (expression) of iNOS mRNA associated with aspirin, dexamethasone and cytokine
4) Confidence 0.61 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.40 Pain Relevance 0.71
OBJECTIVES: The present study tests whether environmental stimuli paired with the administration of heroin alter the expression of inducible nitric oxide synthase (iNOS), one of the isoforms of the enzyme responsible for nitric oxide production.
Spec (whether) Regulation (alter) of Gene_expression (expression) of iNOS
5) Confidence 0.61 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 12457272 Disease Relevance 0 Pain Relevance 0
We have studied the effects of two cannabinoid receptor agonists, WIN 55,212-2 and cannabinol, on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in the C6 glioma cell line.
Regulation (effects) of Gene_expression (expression) of iNOS associated with cannabinoid receptor, agonist and glioma
6) Confidence 0.60 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11520904 Disease Relevance 0.17 Pain Relevance 0.17
Early neuroprotection may to some extent target iNOS via different pathways since all tested drugs affected both iNOS expression and neuronal degeneration.


Regulation (affected) of Gene_expression (expression) of iNOS in neuronal
7) Confidence 0.54 Published 2005 Journal Acta Neurochir (Wien) Section Body Doc Link 16044358 Disease Relevance 0 Pain Relevance 0
The present study tests the hypothesis that expression of inducible nitric oxide synthase (iNOS) is modulated by the administration of the morphine metabolite, morphine-6beta-glucuronide.
Regulation (modulated) of Gene_expression (expression) of inducible nitric oxide synthase associated with morphine
8) Confidence 0.54 Published 2001 Journal Inflammation Section Abstract Doc Link 11580103 Disease Relevance 0 Pain Relevance 0.68
Morphine-6beta-glucuronide modulates the expression of inducible nitric oxide synthase.
Regulation (modulates) of Gene_expression (expression) of inducible nitric oxide synthase associated with morphine
9) Confidence 0.54 Published 2001 Journal Inflammation Section Title Doc Link 11580103 Disease Relevance 0 Pain Relevance 0.92
This study provides the first evidence that heroin induces an alteration of iNOS expression, and suggests that a reduction in nitric oxide production may be involved in the increased incidence of infectious diseases amongst heroin users.
Regulation (alteration) of Gene_expression (expression) of iNOS associated with communicable diseases and opiate addiction
10) Confidence 0.54 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10741899 Disease Relevance 0.31 Pain Relevance 0.19
Heroin modulates the expression of inducible nitric oxide synthase.
Regulation (modulates) of Gene_expression (expression) of inducible nitric oxide synthase
11) Confidence 0.54 Published 2000 Journal Immunopharmacology Section Title Doc Link 10741899 Disease Relevance 0.19 Pain Relevance 0.13
The present study tests the hypothesis that expression of inducible nitric oxide synthase (iNOS) is modulated by the administration of heroin.
Regulation (modulated) of Gene_expression (expression) of inducible nitric oxide synthase
12) Confidence 0.54 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10741899 Disease Relevance 0.19 Pain Relevance 0.06
The effects of local anesthetics on NOS2 expression have not been examined.
Regulation (effects) of Gene_expression (expression) of NOS2 associated with local anesthetic
13) Confidence 0.54 Published 2001 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 11294465 Disease Relevance 0.29 Pain Relevance 0.42
In this paper we examined the effects of KE on nitric oxide (NO) production, expression of inducible nitric oxide synthase (iNOS), osteoblast and osteoclast activity.
Spec (examined) Regulation (effects) of Gene_expression (expression) of inducible nitric oxide synthase in osteoclast associated with osteoporosis
14) Confidence 0.54 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18520054 Disease Relevance 0.89 Pain Relevance 0.17
The modulation of iNOS expression occurs via central opioid receptors as intracerebroventricular administration but not peripheral administration of N-methylnaltrexone, the quaternary form of naltrexone that does not readily cross the blood-brain barrier, reduced the expression of iNOS.
Regulation (modulation) of Gene_expression (expression) of iNOS in brain associated with opioid receptor and intracerebroventricular
15) Confidence 0.54 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918551 Disease Relevance 0 Pain Relevance 0.48
Whether the expression of inducible nitric oxide synthase (iNOS) is affected by exercise is unknown.
Regulation (affected) of Gene_expression (expression) of inducible nitric oxide synthase
16) Confidence 0.54 Published 2002 Journal J. Biomed. Sci. Section Abstract Doc Link 11914582 Disease Relevance 0 Pain Relevance 0.07
The present study was designed to elucidate the mechanisms by which glucocorticoids and NSAIDs affect inducible nitric oxide synthase (iNOS) expression in cultured rat vascular smooth muscle cells (VSMCs).
Regulation (affect) of Gene_expression (expression) of inducible nitric oxide synthase in smooth muscle cells associated with cinod
17) Confidence 0.53 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.55 Pain Relevance 0.50
B targets that affect NOS2 expression as well as simultaneous activation of other signaling pathways involved in the regulation of NOS2 expression likely affect the equilibrium state of NF-?
Regulation (regulation) of Gene_expression (expression) of NOS2
18) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667254 Disease Relevance 0.44 Pain Relevance 0.22
B targets that affect NOS2 expression as well as simultaneous activation of other signaling pathways involved in the regulation of NOS2 expression likely affect the equilibrium state of NF-?
Regulation (affect) of Gene_expression (expression) of NOS2
19) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667254 Disease Relevance 0.31 Pain Relevance 0.19
We have studied the effects of two cannabinoid receptor agonists, WIN 55,212-2 and cannabinol, on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in the C6 glioma cell line.
Regulation (effects) of Gene_expression (production) of inducible nitric oxide synthase associated with cannabinoid receptor, agonist and glioma
20) Confidence 0.53 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11520904 Disease Relevance 0.17 Pain Relevance 0.17

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