INT70504

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 1997
Last Reported 2010
Negated 4
Speculated 17
Reported most in Body
Documents 30
Total Number 49
Disease Relevance 21.72
Pain Relevance 21.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
spinal cord 8
dorsal horns 8
pia mater 6
PGE2 4
heart 4
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 153 100.00 Very High Very High Very High
antagonist 107 100.00 Very High Very High Very High
acular 100 100.00 Very High Very High Very High
cINOD 96 100.00 Very High Very High Very High
cytokine 50 100.00 Very High Very High Very High
substance P 32 100.00 Very High Very High Very High
Arthritis 29 100.00 Very High Very High Very High
Calcitonin gene-related peptide 23 100.00 Very High Very High Very High
Versed 14 100.00 Very High Very High Very High
Endogenous opioid 6 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 164 100.00 Very High Very High Very High
Arthritis 91 100.00 Very High Very High Very High
Nociception 84 100.00 Very High Very High Very High
Hypoxia 58 100.00 Very High Very High Very High
Hyperalgesia 76 99.84 Very High Very High Very High
Nervous System Injury 146 99.76 Very High Very High Very High
Diabetes Mellitus 138 99.72 Very High Very High Very High
Spinal Cord Ischemia 10 99.66 Very High Very High Very High
Inflammatory Pain 49 99.64 Very High Very High Very High
Coronary Artery Disease 4 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, in rats, NO has been shown to play a role in mediating the cardiovascular responses to electroacupuncture at point 36ST [40,41], Second, acupuncture was shown to modulate the expression of NOS under diabetic conditions [42,43].
Regulation (modulate) of Gene_expression (expression) of NOS associated with diabetes mellitus, acupuncture and electroacupuncture
1) Confidence 0.51 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1180462 Disease Relevance 0.17 Pain Relevance 0.25
The two most consistent findings appear to involve changes in neuronal nNOS expression and ICC.
Regulation (changes) of Gene_expression (expression) of nNOS in neuronal
2) Confidence 0.51 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.67 Pain Relevance 0.04
No changes in expression of SP, nNOS, H02 (Figure 2) were noted in sections from the patient with well controlled diabetes when compared to controls.
Neg (No) Regulation (changes) of Gene_expression (expression) of nNOS associated with diabetes mellitus and substance p
3) Confidence 0.51 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.34 Pain Relevance 0.27
expression of the NOS gene, regulation of the
Regulation (regulation) of Gene_expression (expression) of NOS
4) Confidence 0.47 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.57 Pain Relevance 0
The effects of the antiprogestational agent, Mifepristone on the endothelial NOS expression in the endometrium were investigated during the implantation phase [119].
Spec (investigated) Regulation (effects) of Gene_expression (expression) of NOS in endometrium
5) Confidence 0.47 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.11 Pain Relevance 0
It was also found that estrogen treatment down-regulates eNOS and nNOS expression in the rabbit vagina [41].
Regulation (regulates) of Gene_expression (expression) of nNOS in vagina
6) Confidence 0.40 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2907491 Disease Relevance 0 Pain Relevance 0.17
Inducible nitric oxide synthase expression in arthritis
Regulation (arthritis) of Gene_expression (expression) of oxide synthase associated with arthritis
7) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 1.67 Pain Relevance 0.69
The nNOS and iNOS are predominantly soluble enzymes whereas eNOS
Regulation (soluble) of Gene_expression (enzymes) of nNOS
8) Confidence 0.30 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.16 Pain Relevance 0.16
Pathological increases in cellular NO levels due to an increase in iNOS expression or overactivation of eNOS and nNOS result in the formation of peroxynitrite (ONOO-) radical [67].
Regulation (overactivation) of Gene_expression (expression) of nNOS
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.13 Pain Relevance 0
In the present study, we investigated in Wistar rats the effect of air stress on nitric oxide synthase (NOS) mRNA and protein expression in dura and pia mater using real-time polymerase chain reaction and Western blotting, respectively.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of nitric oxide synthase in pia mater associated with stress
10) Confidence 0.30 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.88 Pain Relevance 0.43
When general anaesthesia (GA) is combined with TEA during coronary artery bypass graft, we investigated whether TEA together with GA play a role on VEGF and i-NOS expression in human heart tissue in cardiac ischemia.
Spec (whether) Regulation (role) of Gene_expression (expression) of i-NOS in heart associated with anesthesia, coronary artery disease and ischemia
11) Confidence 0.28 Published 2007 Journal J Cardiovasc Surg (Torino) Section Abstract Doc Link 17308528 Disease Relevance 0.10 Pain Relevance 0.50
However, we did not observe the expression of iNOS or nNOS (protein) as well as no production of NO (function) in our model (data not shown).
Neg (not) Spec (observe) Regulation (observe) of Gene_expression (expression) of nNOS
12) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.14 Pain Relevance 0
Analysis of NOS expression and eNOS phosphorylation
Regulation (Analysis) of Gene_expression (expression) of NOS
13) Confidence 0.24 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
The study was aimed to investigate the protective effects of rosuvastatin on spinal cord ischemia in rats and to determine the effects of this agent on the expressions of nitric oxide synthase (NOS).
Spec (determine) Regulation (effects) of Gene_expression (expressions) of nitric oxide synthase in spinal cord associated with ischemia and spinal cord
14) Confidence 0.24 Published 2010 Journal Brain Res. Section Abstract Doc Link 20513366 Disease Relevance 0.27 Pain Relevance 0.27
The levels of NOS are altered by a variety of pathophysiological conditions such as hypertension, hypercholesterolemia, aging, cigarette smoking, diabetes, heart failure and under physical activity [13] and dementia [14].
Regulation (altered) of Gene_expression (levels) of NOS in heart associated with dementia, nicotine addiction, aging, diabetes mellitus, hypertension, hyperlipidemia and myocardial infarction
15) Confidence 0.22 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1180462 Disease Relevance 0.67 Pain Relevance 0.07
In the present study, we investigated in Wistar rats the effect of air stress on nitric oxide synthase (NOS) mRNA and protein expression in dura and pia mater using real-time polymerase chain reaction and Western blotting, respectively.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of NOS in pia mater associated with stress
16) Confidence 0.22 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.88 Pain Relevance 0.43
Despite the important role of NOS in spinal cord nociceptive transmission, there have been no studies exploring the effect of NMDA receptor blockade on NOS expression in the dorsal horn during chronic pain.
Regulation (effect) of Gene_expression (expression) of NOS in dorsal horn associated with nociception, lasting pain, nmda receptor, dorsal horn and spinal cord
17) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206346 Disease Relevance 0.63 Pain Relevance 0.81
In the present study, we have examined the distribution of NOS isoform expression to determine whether their regulation is consistent with a role in the inhibition of uterine contractions before term.
Spec (examined) Regulation (distribution) of Gene_expression (expression) of NOS in uterine associated with dismenorea
18) Confidence 0.19 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9227445 Disease Relevance 0.10 Pain Relevance 0.10
Inducible NOS mRNA and protein expression levels in dura and pia mater were unaffected by stress.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of NOS in pia mater associated with stress
19) Confidence 0.19 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.93 Pain Relevance 0.51
The effect of ketorolac on NO production and nitric oxide synthase (NOS) gene expression was also studied.


Regulation (effect) of Gene_expression (expression) of nitric oxide synthase associated with acular
20) Confidence 0.19 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2949722 Disease Relevance 0.41 Pain Relevance 0.56

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox