INT70505

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.22
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
neurons 2
dorsal root ganglion 2
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 4 100.00 Very High Very High Very High
Inflammation 2 100.00 Very High Very High Very High
bradykinin 10 99.98 Very High Very High Very High
dorsal root ganglion 6 99.58 Very High Very High Very High
COX-2 inhibitor 1 82.52 Quite High
aspirin 5 75.16 Quite High
cINOD 2 75.00 Quite High
b2 receptor 2 56.96 Quite High
antagonist 40 56.48 Quite High
B1 receptor 1 55.28 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 11 100.00 Very High Very High Very High
INFLAMMATION 3 100.00 Very High Very High Very High
Adhesions 2 100.00 Very High Very High Very High
Ganglion Cysts 8 99.58 Very High Very High Very High
Fever 9 99.16 Very High Very High Very High
Diabetic Retinopathy 5 75.00 Quite High
Hyperglycemia 1 68.88 Quite High
Death 2 65.44 Quite High
Hypertension 1 26.08 Quite Low
Stress 12 17.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The long-term exposure of rat cultured dorsal root ganglion cells to bradykinin induced the release of prostaglandin E2 by the activation of cyclooxygenase-2.
Positive_regulation (induced) of Positive_regulation (activation) of cyclooxygenase-2 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, cox2 and bradykinin
1) Confidence 0.49 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16580130 Disease Relevance 0.44 Pain Relevance 0.87
We previously showed that a febrile dose of lipopolysaccharide (LPS) in rats resulted in induction of cyclooxygenase-2 (COX-2) mRNA in brain blood vessels/leptomeninges and telencephalic neurons.
Positive_regulation (resulted) of Positive_regulation (induction) of cyclooxygenase-2 in neurons associated with fever
2) Confidence 0.29 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9227582 Disease Relevance 0.45 Pain Relevance 0
Sulfasalazine (also as a representative of the salicylates) inhibited the diabetes-induced upregulation of several inflammatory gene products, which are regulated by NF-kappaB, including vascular cell adhesion molecule, intracellular adhesion molecule-1, inducible nitric oxide synthase, and cyclooxygenase-2 in whole-retinal lysate.
Positive_regulation (diabetes-induced) of Positive_regulation (upregulation) of cyclooxygenase-2 associated with inflammation, diabetes mellitus and adhesions
3) Confidence 0.19 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.21 Pain Relevance 0.16
OTR activation leads to the stimulation of phospholipase A2 production and an increase in cyclooxygenase 2 levels, both resulting in increased prostaglandin production.
Positive_regulation (stimulation) of Positive_regulation (increase) of cyclooxygenase 2 associated with cox2
4) Confidence 0.03 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.11 Pain Relevance 0.05

General Comments

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