INT70515

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.26
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (Slc22a6) plasma membrane (Slc22a6) protein complex (Slc22a6)
Anatomy Link Frequency
kidney 2
oocytes 1
Slc22a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 1 99.06 Very High Very High Very High
cINOD 3 94.88 High High
methotrexate 2 83.00 Quite High
vincristine 1 82.44 Quite High
Paracetamol 8 69.60 Quite High
aspirin 1 63.20 Quite High
Angina 1 59.96 Quite High
addiction 2 50.16 Quite High
Bile 1 46.88 Quite Low
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 1 99.06 Very High Very High Very High
Injury 92 98.82 Very High Very High Very High
INFLAMMATION 5 94.68 High High
Uremia 7 75.00 Quite High
Overdose 4 69.96 Quite High
Chronic Renal Failure 10 65.44 Quite High
Arrhythmias 2 Under Development 1 60.92 Quite High
Cv General 3 Under Development 1 59.96 Quite High
Toxicity 19 33.16 Quite Low
Poisoning 6 30.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Northern blot analysis and in situ hybridization revealed that OAT1 is exclusively expressed in the particular segment of the proximal tubule in the kidney.
Gene_expression (expressed) of OAT1 in kidney
1) Confidence 0.78 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9228014 Disease Relevance 0.09 Pain Relevance 0.09
When expressed in Xenopus laevis oocytes, OAT1 mediated sodium-independent para-aminohippurate (PAH) uptake (Km = 14.3 +/- 2.9 microM).
Gene_expression (expressed) of OAT1 in oocytes
2) Confidence 0.67 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9228014 Disease Relevance 0.06 Pain Relevance 0.06
For example, the expression of the basolateral membrane organic anion transporter-1 (Oat1), which has been implicated in the transport of MeHg–NAC complex (Koh et al. 2002), is greater in male rats than in females (Buist et al. 2002).
Gene_expression (expression) of Oat1
3) Confidence 0.65 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0 Pain Relevance 0
In particular, expression of Oat1 in rat kidney is low at birth, but it approaches adult levels at around 30 days of age (Buist et al. 2002).
Gene_expression (expression) of Oat1 in kidney
4) Confidence 0.65 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0.13 Pain Relevance 0.15
The renal and hepatic uptake transporters for these metabolites were investigated by assessing their inhibitory effect on uptake activity in human (h) organic cation transporter (OCT) 1-3/rat (r) Oct1-3, human organic anion transporter (OAT) 1/rOat1, hOAT3/rOat3, and organic anion-transporting protein 1B1/1B3-expressing HEK293 cells.
Gene_expression (expressing) of rOat1
5) Confidence 0.58 Published 2009 Journal Drug Metab. Dispos. Section Abstract Doc Link 19439489 Disease Relevance 0.12 Pain Relevance 0.06
Protein expression of rOat1 and rOat3, assessed by Western blot analysis, was decreased in 5/6 Nx rats.
Gene_expression (expression) of rOat1
6) Confidence 0.47 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15879000 Disease Relevance 0.27 Pain Relevance 0
Induction of AKI in ischemia-reperfusion rat models demonstrates decreased OAT1 and OAT3 mRNA as well as protein expression [34-36].
Gene_expression (expression) of OAT1 associated with ischemia and injury
7) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.58 Pain Relevance 0.26

General Comments

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