INT70521

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.54
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcna1) transmembrane transport (Kcna1)
Anatomy Link Frequency
neurons 1
Kcna1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 13 99.88 Very High Very High Very High
antinociception 3 99.56 Very High Very High Very High
tricyclic antidepressant 2 98.32 Very High Very High Very High
Endep 7 95.64 Very High Very High Very High
depression 1 90.76 High High
tetrodotoxin 1 85.36 High High
Hippocampus 4 80.36 Quite High
analgesia 2 75.00 Quite High
gABA 1 73.52 Quite High
Analgesic 1 67.04 Quite High
Disease Link Frequency Relevance Heat
Adhesions 20 98.68 Very High Very High Very High
Depression 1 90.76 High High
Cancer 4 85.44 High High
Toxicity 1 57.12 Quite High
Metastasis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Psychosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data show that hippocampal neurons in culture are a convenient model to study the developmental expression and regulation of Kv1 channels.
Regulation (regulation) of Kv1 in neurons
1) Confidence 0.50 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684888 Disease Relevance 0.09 Pain Relevance 0.27
The effect of an antisense oligonucleotide to the K+ channel coding mKv1.1 mRNA on antinociception induced by the tricyclic antidepressants, clomipramine (20-35 mg kg(-1) s.c.) and amitriptyline (10-25 mg kg(-1) s.c.), was investigated in the mouse hot-plate test.
Spec (investigated) Regulation (effect) of mKv1 associated with antinociception, endep and tricyclic antidepressant
2) Confidence 0.07 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9228410 Disease Relevance 0.06 Pain Relevance 0.49
One established function of sigma-1 receptors is modulation of the activity of Kv1.4 potassium channels, presumably as regulatory inhibitory subunits of these channels[11].
Regulation (modulation) of Kv1 associated with potassium channel
3) Confidence 0.00 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.13 Pain Relevance 0.13
Although the state of localization of Kv1.4 potassium channels was not assessed with regard to the sigma-1 receptor ligands in this study, it is reasonable to propose that increased focal adhesion targeting of the sigma-1 receptors is a regulatory mechanism for modulation of Kv1.4 voltage-gated channels in FAC in CHO-K1 cells.
Regulation (modulation) of Kv1 associated with potassium channel and adhesions
4) Confidence 0.00 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.26 Pain Relevance 0.23

General Comments

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