INT70522

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 0.73
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcna1) transmembrane transport (Kcna1)
Anatomy Link Frequency
pyramidal cells 4
Kcna1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 5 99.62 Very High Very High Very High
cerebral cortex 25 98.90 Very High Very High Very High
Neuronal excitability 37 98.00 Very High Very High Very High
analgesia 2 97.88 Very High Very High Very High
tricyclic antidepressant 2 96.88 Very High Very High Very High
Endep 7 95.12 Very High Very High Very High
hyperexcitability 1 90.08 High High
Neuropathic pain 1 86.00 High High
Hippocampus 16 85.44 High High
potassium channel 50 80.12 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 245 94.16 High High
Attention Deficit Hyperactivity Disorder 15 87.92 High High
Myoclonus 5 86.92 High High
Convulsion 166 84.12 Quite High
Toxicity 1 74.80 Quite High
Sleep Disorders 70 59.52 Quite High
Lifespan 20 5.00 Very Low Very Low Very Low
Embryonic Lethality 5 5.00 Very Low Very Low Very Low
Syndrome 5 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the supragranular layers of the rat cerebral cortex, for instance, most pyramidal cells contain different combinations of Kv1.1, Kv1.2, Kv1.3, and Kv1.4 subunits, localized in both the somatodendritic and the axonal compartments [7].
Kv1 Binding (combinations) of in pyramidal cells associated with pyramidal cell and cerebral cortex
1) Confidence 0.36 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0 Pain Relevance 0.29
In the supragranular layers of the rat cerebral cortex, for instance, most pyramidal cells contain different combinations of Kv1.1, Kv1.2, Kv1.3, and Kv1.4 subunits, localized in both the somatodendritic and the axonal compartments [7].
Kv1 Binding (combinations) of in pyramidal cells associated with pyramidal cell and cerebral cortex
2) Confidence 0.36 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0 Pain Relevance 0.29
In the supragranular layers of the rat cerebral cortex, for instance, most pyramidal cells contain different combinations of Kv1.1, Kv1.2, Kv1.3, and Kv1.4 subunits, localized in both the somatodendritic and the axonal compartments [7].
Kv1 Binding (combinations) of in pyramidal cells associated with pyramidal cell and cerebral cortex
3) Confidence 0.36 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0 Pain Relevance 0.29
In the supragranular layers of the rat cerebral cortex, for instance, most pyramidal cells contain different combinations of Kv1.1, Kv1.2, Kv1.3, and Kv1.4 subunits, localized in both the somatodendritic and the axonal compartments [7].
Kv1 Binding (combinations) of in pyramidal cells associated with pyramidal cell and cerebral cortex
4) Confidence 0.36 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0 Pain Relevance 0.29
In Kv1.2-deficient pups, instead, the decrease in NREM sleep amount was not associated with signs of sleep fragmentation, because there were no differences in the number and duration of NREM sleep episodes, or in the number of brief awakenings, between KO, HZ, and WT mice.
Kv1 Binding (associated) of associated with targeted disruption
5) Confidence 0.31 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.57 Pain Relevance 0.13
It is likely that these disinactivators act directly on the Kvbeta1 N-terminus or its receptor site on Kv1.1, thus preventing it from blocking Kv1.1 channels.
Kv1 Spec (likely) Binding (act) of
6) Confidence 0.24 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18226531 Disease Relevance 0.08 Pain Relevance 0.23
The present results indicate that modulation of the mKv1.1 K+ channel plays an important role in the central analgesia induced by the tricyclic antidepressants, clomipramine and amitriptyline.
mKv1 Binding (modulation) of associated with endep, tricyclic antidepressant and analgesia
7) Confidence 0.05 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9228410 Disease Relevance 0.07 Pain Relevance 0.71

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