INT70526

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.09
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (CALR) Golgi apparatus (CALR) endoplasmic reticulum (CALR)
intracellular (CALR) DNA binding (CALR) cytoplasm (CALR)
Anatomy Link Frequency
spine 1
CALR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 2 99.90 Very High Very High Very High
Somatostatin 6 99.36 Very High Very High Very High
agonist 46 99.26 Very High Very High Very High
Inflammation 18 97.68 Very High Very High Very High
Arthritis 2 93.88 High High
Dopamine 4 92.96 High High
dopamine receptor 2 90.64 High High
rheumatoid arthritis 59 86.60 High High
GABAergic 16 77.88 Quite High
carpal tunnel syndrome 1 77.72 Quite High
Disease Link Frequency Relevance Heat
Togavirus Infection 3 100.00 Very High Very High Very High
Cancer 88 99.98 Very High Very High Very High
Autoimmune Disease 9 99.78 Very High Very High Very High
INFLAMMATION 17 99.72 Very High Very High Very High
Pancreatic Cancer 120 98.96 Very High Very High Very High
Metastasis 22 98.72 Very High Very High Very High
Toxicity 6 98.56 Very High Very High Very High
Fatigue 3 98.04 Very High Very High Very High
Lordosis 8 97.88 Very High Very High Very High
Scotoma 2 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This modified trimeric SP-D variant would subsequently initiate a pro-inflammatory response via calreticulin/CD91 receptor interaction and activate p38 MAPK [48].
calreticulin Binding (interaction) of associated with inflammatory response
1) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.95 Pain Relevance 0.37
The concurrent CRT was found to be more myelosuppressive and was also associated with considerable gastrointestinal toxicity and fatigue.
CRT Binding (associated) of associated with toxicity and fatigue
2) Confidence 0.14 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 0.72 Pain Relevance 0
Although interactions with calreticulin, PDI and GRP94 appear to be conserved through all receptor pairs, differences in the interaction pattern can be observed in the case of Bip, which interacts only with the ?
calreticulin Binding (interactions) of
3) Confidence 0.14 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0
interaction in the CRT in sensitive subjects and, similarly, a
CRT Binding (interaction) of
4) Confidence 0.12 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1552030 Disease Relevance 0.30 Pain Relevance 0
Until such trials are available, a reasonable standard of care for locally advanced pancreatic cancer is the RTOG 97-04 sandwich approach with full-dose gemcitabine before and after CRT with 5-FU.39


CRT Binding (gemcitabine) of associated with pancreatic cancer
5) Confidence 0.11 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 0.93 Pain Relevance 0.26
To define a possible link between rubella and autoimmunity in vitro, interactions of rubella RNA, ribonucleoprotein complexes including Ro and La, and calreticulin were explored.
calreticulin Binding (interactions) of associated with autoimmune disease and togavirus infection
6) Confidence 0.10 Published 1997 Journal Curr Opin Rheumatol Section Abstract Doc Link 9229181 Disease Relevance 2.35 Pain Relevance 0.24
In all cases, an improvement of cervical sagittal alignment in terms of physiologic cervical lordosis recovery was achieved postoperatively compared with preoperative values.Fig. 2Average sagittal segmental alignment (SSA) angleFig. 3Average sagittal alignment of the cervical spine (SACS) angle
SSA Binding (alignment) of in spine associated with lordosis
7) Confidence 0.07 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896578 Disease Relevance 0.32 Pain Relevance 0.24
, calcium-binding proteins such as calmodulin (presumably requiring pharmacological levels because of low affinity), calreticulin, nuclear calreticulin analogs, and two mitochondrial binding sites, one of which is located at the amphipathic ramp of complex 1 and displays high affinity to the indoleamine.19,21,43–45 The majority of synthetic agonists has not been tested for these binding sites, with the exception of ramelteon, which has a low affinity to quinone reductase 2,46 and does not seem to act via calmodulin.21
calreticulin Binding (binding) of associated with agonist
8) Confidence 0.06 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0.14 Pain Relevance 0.12
, calcium-binding proteins such as calmodulin (presumably requiring pharmacological levels because of low affinity), calreticulin, nuclear calreticulin analogs, and two mitochondrial binding sites, one of which is located at the amphipathic ramp of complex 1 and displays high affinity to the indoleamine.19,21,43–45 The majority of synthetic agonists has not been tested for these binding sites, with the exception of ramelteon, which has a low affinity to quinone reductase 2,46 and does not seem to act via calmodulin.21
calreticulin Binding (binding) of associated with agonist
9) Confidence 0.06 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0.14 Pain Relevance 0.12
GH secretion is regulated through ligand binding of somatostatin to both sst2 and sst5, whereas SSA binds preferentially sst2 [26].
SSA Binding (binds) of associated with somatostatin
10) Confidence 0.03 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.10 Pain Relevance 0.16
DA seem to be more effective on tumour shrinkage than SSA.
SSA Binding (shrinkage) of associated with cancer and agonist
11) Confidence 0.02 Published 2008 Journal Endocr. Relat. Cancer Section Abstract Doc Link 18780796 Disease Relevance 1.15 Pain Relevance 0.45

General Comments

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