INT70529

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 14.43
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cish)
Anatomy Link Frequency
CSF 2
SH2 1
puncture 1
Cish (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 253 100.00 Very High Very High Very High
cytokine 424 99.98 Very High Very High Very High
Inflammation 30 98.88 Very High Very High Very High
Ultiva 2 96.16 Very High Very High Very High
imagery 140 93.08 High High
intrathecal 45 88.40 High High
analgesia 17 80.48 Quite High
Neuritis 7 80.00 Quite High
rheumatoid arthritis 17 76.36 Quite High
Potency 1 68.32 Quite High
Disease Link Frequency Relevance Heat
Syndrome 314 100.00 Very High Very High Very High
Demyelinating Disease 274 100.00 Very High Very High Very High
Sepsis 296 98.96 Very High Very High Very High
INFLAMMATION 31 98.88 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 2 95.56 Very High Very High Very High
Togavirus Infection 65 95.12 Very High Very High Very High
Multiple Sclerosis 2 93.92 High High
Disorder Of Lipid Metabolism 9 89.52 High High
Herpes Zoster 55 84.52 Quite High
Measles 55 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CIS scores were increased in women when pregnant (Mean 23.5, SD 6.9) compared to when they were not pregnant (Mean 18.7, SD 6.6), p < 0.001.
Positive_regulation (increased) of CIS
1) Confidence 0.59 Published 2009 Journal Am J Clin Hypn Section Abstract Doc Link 19678556 Disease Relevance 0 Pain Relevance 0.08
A positive MRZS >10 points was significantly more frequent in CIS-RRMS as compared to CIS-CIS (p?
Positive_regulation (frequent) of CIS-RRMS associated with syndrome
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766627 Disease Relevance 1.94 Pain Relevance 0.17
A positive MRZR was significantly more frequent in CIS-RRMS as compared to CIS-CIS (p?
Positive_regulation (frequent) of CIS-RRMS associated with syndrome
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766627 Disease Relevance 1.74 Pain Relevance 0.22
In a study employing a rodent model of sepsis – cecal ligation and puncture (CLP) – a relationship was observed between the induction of SOCS and both the presence of sepsis and the administration of PN [14].
Positive_regulation (induction) of SOCS in puncture associated with sepsis
4) Confidence 0.31 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.43 Pain Relevance 0.29
The induction of SOCS proteins by hormones and/or cytokines has been hypothesized to inhibit GH signaling by a negative feedback loop involving the janus kinase and signal transducer and activator pathway [12].
Positive_regulation (induction) of SOCS associated with cytokine
5) Confidence 0.31 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.35 Pain Relevance 0.05
In a prospective study of the Department of Neurology, University of Ulm (Germany), we collected CSF samples from patients with CIS that remained CIS (CIS-CIS) over a follow-up of 2 years and from patients with CIS that developed definite MS of the relapsing-remitting subtype (CIS-RRMS) over the same period [2] (Table 1).
Positive_regulation (remained) of CIS in CSF associated with multiple sclerosis and syndrome
6) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766627 Disease Relevance 1.72 Pain Relevance 0.43
In a prospective study of the Department of Neurology, University of Ulm (Germany), we collected CSF samples from patients with CIS that remained CIS (CIS-CIS) over a follow-up of 2 years and from patients with CIS that developed definite MS of the relapsing-remitting subtype (CIS-RRMS) over the same period [2] (Table 1).
Positive_regulation (remained) of CIS-CIS in CSF associated with multiple sclerosis and syndrome
7) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766627 Disease Relevance 1.73 Pain Relevance 0.43
MRZR was determined in a prospective study over 2 years including 40 patients that remained CIS over follow-up (CIS-CIS) and 49 patients that developed MS (CIS-RRMS) using ELISA.
Positive_regulation (remained) of CIS associated with multiple sclerosis and syndrome
8) Confidence 0.31 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2766627 Disease Relevance 2.01 Pain Relevance 0.18
The MNE of mRNA for CIS was significantly increased in CLP-EN rats compared with Sham-EN animals and compared with animals from the other CLP groups (Figure 3).
Positive_regulation (increased) of CIS
9) Confidence 0.27 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.13 Pain Relevance 0.16
Administration of 16 hours of PN was associated with induction of the expression of hepatic mRNA of the SOCS cytokine-inducible SH2-containing protein (CIS).
Positive_regulation (inducible) of CIS in SH2 associated with cytokine
10) Confidence 0.22 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.42 Pain Relevance 0.28
SOCS-1 and CIS expression were increased 4 hours following induction of sepsis, but by 24 hours were no different from measurements in sham-operated animals – whereas SOCS-3 expression remained elevated at 24 hours.
Positive_regulation (increased) of SOCS associated with sepsis
11) Confidence 0.22 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.47 Pain Relevance 0.11
Increased hepatic mRNA of SOCS proteins has been shown to occur transiently in abdominal sepsis and to be temporally associated with the development of GH resistance [13].
Positive_regulation (Increased) of SOCS associated with sepsis
12) Confidence 0.21 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.39 Pain Relevance 0.29
Hepatic mRNA of CIS, SOCS-2 and SOCS-3 is transiently increased following endotoxin administration [31], while SOCS-1 expression and SOCS-3 expression were found to be increased 24 hours following CLP [14].
Positive_regulation (increased) of CIS
13) Confidence 0.21 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.47 Pain Relevance 0.13
Hepatic mRNA of CIS, SOCS-2 and SOCS-3 is transiently increased following endotoxin administration [31], while SOCS-1 expression and SOCS-3 expression were found to be increased 24 hours following CLP [14].
Positive_regulation (increased) of SOCS
14) Confidence 0.09 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.47 Pain Relevance 0.13
Similar to the Shore ea al, our research showed increased serum apoA-I levels in MS patients and other autoimmune demyelinating disease (CIS, GBS) whether male and female patients.
Spec (whether) Positive_regulation (increased) of CIS associated with multiple sclerosis, syndrome and demyelinating disease
15) Confidence 0.09 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 2.16 Pain Relevance 0.63
Cis-atracurium is preferentially degraded and inactivated by a process known as Hofmann elimination.
Positive_regulation (inactivated) of Cis-atracurium
16) Confidence 0.00 Published 1997 Journal Anaesthesist Section Abstract Doc Link 9229981 Disease Relevance 0 Pain Relevance 0.22

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