INT70538

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Context Info
Confidence 0.54
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 3.08
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
eosinophil 4
PGE2 2
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 18 100.00 Very High Very High Very High
Central nervous system 5 99.28 Very High Very High Very High
Potency 9 98.08 Very High Very High Very High
aspirin 6 94.40 High High
Inflammation 9 93.56 High High
cytokine 1 82.88 Quite High
rheumatoid arthritis 1 70.56 Quite High
COX2 1 25.00 Low Low
cva 5 13.64 Low Low
halothane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 19 100.00 Very High Very High Very High
Disease 18 99.70 Very High Very High Very High
Infection 4 99.50 Very High Very High Very High
Systemic Lupus Erythematosus 5 99.12 Very High Very High Very High
Paralysis 17 96.00 Very High Very High Very High
Alzheimer's Dementia 23 94.56 High High
Lyme Neuroborreliosis 53 91.84 High High
Amyloid Plaque 2 87.12 High High
Neurodegenerative Disease 2 83.48 Quite High
Facial Paralysis 8 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of topical anti-inflammatory drugs on epithelial cell-induced eosinophil survival and GM-CSF secretion.
Regulation (Effect) of Localization (secretion) of GM-CSF in eosinophil associated with inflammation and cinod
1) Confidence 0.54 Published 1997 Journal Eur. Respir. J. Section Title Doc Link 9230235 Disease Relevance 0.20 Pain Relevance 0.23
We investigated the effect of fluticasone propionate, budesonide, beclomethasone dipropionate and nedocromil sodium on the release of granulocyte/macrophage colony-stimulating factor (GM-CSF) and on eosinophil survival induced by secretions from cultured nasal epithelial cells.
Spec (investigated) Regulation (effect) of Localization (release) of GM-CSF in eosinophil
2) Confidence 0.39 Published 1997 Journal Eur. Respir. J. Section Abstract Doc Link 9230235 Disease Relevance 0.17 Pain Relevance 0.20
The effects of NSAIDs and NO-NSAIDs on GM-CSF release were attributable to the PGE2 mediated cyclic (c) AMP pathway because PGE2 reversed the effects of COX blockade.
Regulation (effects) of Localization (release) of GM-CSF in PGE2 associated with cinod
3) Confidence 0.39 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.14 Pain Relevance 0.94
Given that the Microfil distribution patterns in sheep, pigs, rabbits, rats, mice, Barbados green monkeys and humans appear remarkably similar, it would seem likely that this pathway is important for CSF clearance in each of these species.
Spec (likely) Regulation (important) of Localization (clearance) of CSF
4) Confidence 0.38 Published 2004 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC546409 Disease Relevance 0 Pain Relevance 0
These drugs may exert part of their therapeutic effect by modulating GM-CSF release.
Regulation (modulating) of Localization (release) of GM-CSF
5) Confidence 0.24 Published 1997 Journal Eur. Respir. J. Section Abstract Doc Link 9230235 Disease Relevance 0.17 Pain Relevance 0.29
Net effects on sAPP proteins differ from what is seen in MS, cerebral SLE and CNS infections, since AD patients have unaltered or even elevated CSF levels of ?
Regulation (unaltered) of Localization (levels) of CSF associated with central nervous system, disease, systemic lupus erythematosus and infection
6) Confidence 0.06 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902447 Disease Relevance 2.41 Pain Relevance 0.23

General Comments

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