INT70539

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 7.15
Pain Relevance 4.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
neutrophil 4
bowel 1
Kupffer cells 1
Cxcl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 86 100.00 Very High Very High Very High
chemokine 46 100.00 Very High Very High Very High
Paracetamol 4 99.76 Very High Very High Very High
Hyperalgesia 16 99.60 Very High Very High Very High
antagonist 14 97.88 Very High Very High Very High
Inflammation 175 95.24 Very High Very High Very High
Inflammatory response 23 92.32 High High
nociceptor 11 90.88 High High
dexamethasone 2 88.52 High High
intrathecal 1 82.16 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 20 100.00 Very High Very High Very High
Necrosis 17 100.00 Very High Very High Very High
Cancer 14 100.00 Very High Very High Very High
Urological Neuroanatomy 12 100.00 Very High Very High Very High
Hyperalgesia 26 99.98 Very High Very High Very High
Pneumonia 4 95.24 Very High Very High Very High
Apoptosis 11 94.48 High High
Systemic Inflammatory Response Syndrome 5 94.48 High High
INFLAMMATION 210 92.32 High High
Adhesions 17 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
or CXCL1/KC was reduced in casp1-/- mice compared with WT mice (Figure 3A).
Negative_regulation (reduced) of CXCL1
1) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.47 Pain Relevance 0.27
The amount of monomeric CINC liberated by Kupffer cells was diminished upon acetaminophen-treatment.
Negative_regulation (diminished) of CINC in Kupffer cells associated with paracetamol
2) Confidence 0.50 Published 1997 Journal Toxicology Section Abstract Doc Link 9230444 Disease Relevance 0.26 Pain Relevance 0.39
The development of intestinal lesions in response to indomethacin was prevented in Ws/Ws rats compared with W+/W+ rats, together with significant suppression of the increased levels of TBARS, MPO activities, and CINC-1 levels.
Negative_regulation (suppression) of CINC-1
3) Confidence 0.43 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19148791 Disease Relevance 0.07 Pain Relevance 0
The hyperalgesic effect of cytokine-induced neutrophil chemoattractant 1 (CINC-1/CXCL1) was measured in a model of mechanical hyperalgesia in rats.
Negative_regulation (effect) of CINC-1 in neutrophil associated with hyperalgesia and cytokine
4) Confidence 0.43 Published 2002 Journal Eur. Cytokine Netw. Section Abstract Doc Link 12517731 Disease Relevance 0.49 Pain Relevance 0.30
The development of intestinal lesions in response to indomethacin was dose-dependently prevented by lansoprazole at a dose of 5 mg/kg together with significant suppression of the increased level of TBARS, MPO activities and CINC-1 in the small bowel.
Negative_regulation (suppression) of CINC-1 in bowel associated with urological neuroanatomy
5) Confidence 0.43 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16328016 Disease Relevance 0.64 Pain Relevance 0.25
and CXCL1/KC was reduced in casp1-/- mice compared with WT mice.
Negative_regulation (reduced) of CXCL1
6) Confidence 0.42 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2959021 Disease Relevance 0.71 Pain Relevance 0.33
CINC-1 evoked a dose-dependent mechanical hypersensitivity, which was already significant 2 h after the cytokine injection, peaked 4 h after and decreased thereafter.
Negative_regulation (decreased) of CINC-1 associated with hypersensitivity and cytokine
7) Confidence 0.38 Published 2002 Journal Eur. Cytokine Netw. Section Abstract Doc Link 12517731 Disease Relevance 0.65 Pain Relevance 0.32
The hyperalgesic effect of cytokine-induced neutrophil chemoattractant 1 (CINC-1/CXCL1) was measured in a model of mechanical hyperalgesia in rats.
Negative_regulation (effect) of chemoattractant 1 in neutrophil associated with hyperalgesia and cytokine
8) Confidence 0.37 Published 2002 Journal Eur. Cytokine Netw. Section Abstract Doc Link 12517731 Disease Relevance 0.49 Pain Relevance 0.30
Group CLP+O3 had a significant decrease in CINC-1 levels when compared to all of the CLP-procedure groups.
Negative_regulation (decrease) of CINC-1
9) Confidence 0.29 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827707 Disease Relevance 0.61 Pain Relevance 0.12
The hyperalgesic effect of cytokine-induced neutrophil chemoattractant 1 (CINC-1/CXCL1) was measured in a model of mechanical hyperalgesia in rats.
Negative_regulation (effect) of CXCL1 in neutrophil associated with hyperalgesia and cytokine
10) Confidence 0.19 Published 2002 Journal Eur. Cytokine Netw. Section Abstract Doc Link 12517731 Disease Relevance 0.49 Pain Relevance 0.31
Co-administration of the selective P2X3,2/3 receptors antagonist A-317491, or the non-selective P2X3 receptor antagonist, TNP-ATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan, and significantly reduced the increased concentration of tumor necrosis factor alpha (TNF-alpha) and chemokine-induced chemoattractant-1 (CINC-1) but not of interleukin-1 beta (IL-1 beta) induced by carrageenan.
Negative_regulation (reduced) of CINC-1 associated with chemokine, necrosis, hyperalgesia, cancer and antagonist
11) Confidence 0.17 Published 2009 Journal Pain Section Abstract Doc Link 19081189 Disease Relevance 0.97 Pain Relevance 0.98
DPML significantly inhibited tumor necrosis factor alpha, interleukin-1beta, and cytokine-induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and inhibited NFkappaB and p38 mitogen-activated protein kinase activation in the lung.
Negative_regulation (suppressed) of chemoattractant-1 in neutrophil associated with necrosis, cancer and cytokine
12) Confidence 0.04 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18669445 Disease Relevance 0.73 Pain Relevance 0.57
Inhibition of CINC, using antibodies, reduces infarct size in a transient MCAo model when given before (1 day) and upon reperfusion [89].
Negative_regulation (Inhibition) of CINC
13) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.58 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox