INT7055

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Context Info
Confidence 0.34
First Reported 1992
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.22
Pain Relevance 4.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
temporal lobe 2
FAIM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 136 100.00 Very High Very High Very High
narcan 12 99.80 Very High Very High Very High
agonist 11 98.64 Very High Very High Very High
opiate 6 97.56 Very High Very High Very High
addiction 18 97.48 Very High Very High Very High
antagonist 2 97.12 Very High Very High Very High
Morphine 9 96.56 Very High Very High Very High
Opioid 75 93.24 High High
Enkephalin 6 92.16 High High
withdrawal 44 90.00 High High
Disease Link Frequency Relevance Heat
Epilepsy 7 99.74 Very High Very High Very High
Convulsion 7 94.40 High High
Bordatella Infection 1 93.68 High High
Opiate Addiction 17 93.64 High High
Depression 5 75.20 Quite High
Pain 3 64.40 Quite High
Substance Withdrawal Syndrome 10 45.12 Quite Low
Sprains And Strains 13 43.04 Quite Low
Overdose 3 33.08 Quite Low
Respiratory Failure 3 32.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with temporal lobe epilepsy demonstrate enhanced mu receptor binding in the neocortex of the epileptogenic temporal lobe on PET.
Positive_regulation (enhanced) of mu receptor Binding (binding) of in temporal lobe associated with epilepsy
1) Confidence 0.34 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1337448 Disease Relevance 0.88 Pain Relevance 0.99
Incubation with sucrose 0.45 M significantly inhibited ohmefentanyl-induced internalization of the mu receptor.
Positive_regulation (ohmefentanyl-induced) of mu receptor Binding (internalization) of
2) Confidence 0.16 Published 2003 Journal Life Sci. Section Abstract Doc Link 12726892 Disease Relevance 0.09 Pain Relevance 0.70
While buprenorphine’s manner of interacting with the mu receptor gives rise to its most important attributes and advantages in addiction treatment, the medication also has a significant action at a second receptor:
Positive_regulation (buprenorphine) of mu receptor Binding (interacting) of associated with addiction and buprenorphine
3) Confidence 0.11 Published 2004 Journal Sci Pract Perspect Section Body Doc Link PMC2851017 Disease Relevance 0.18 Pain Relevance 1.54
Replacement of TM II Asp114 with asparagine or glutamic acid increased mu receptor affinity for naloxone.
Positive_regulation (increased) of mu receptor Binding (affinity) of associated with narcan
4) Confidence 0.03 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8051154 Disease Relevance 0.06 Pain Relevance 1.12

General Comments

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