INT70555

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 3.62
Pain Relevance 12.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
neurons 1
lamina 1
nociceptors 1
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 1186 100.00 Very High Very High Very High
Neuropeptide 27 100.00 Very High Very High Very High
Inflammation 15 100.00 Very High Very High Very High
calcitonin gene related peptide 22 99.90 Very High Very High Very High
Glutamate 50 99.80 Very High Very High Very High
antagonist 47 99.76 Very High Very High Very High
primary afferent fibers 33 99.72 Very High Very High Very High
Dorsal horn 34 99.68 Very High Very High Very High
imagery 11 99.50 Very High Very High Very High
Opioid 6 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 100.00 Very High Very High Very High
Colitis 5 99.32 Very High Very High Very High
Nociception 70 98.72 Very High Very High Very High
Ganglion Cysts 170 98.00 Very High Very High Very High
Disease 2 96.16 Very High Very High Very High
Hyperalgesia 1 91.80 High High
Infection 3 84.32 Quite High
Pseudomonas Infection 2 82.96 Quite High
Targeted Disruption 108 82.08 Quite High
Corneal Perforation 1 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test this, we examined the effect of the SP(1-7) antagonist, D-SP(1-7), injected intrathecally in mice, on two nociceptive assays that are differentially affected by exogenous SP(1-7): acetic acid-induced writhing that is inhibited and formalin-induced behaviors that are enhanced by SP(1-7).
Spec (examined) Regulation (effect) of SP associated with nociception, antagonist and substance p
1) Confidence 0.35 Published 1998 Journal Brain Res. Section Abstract Doc Link 9473599 Disease Relevance 0.36 Pain Relevance 0.86
This effect on SP has been hypothesized to mediate the antinociceptive effect of capsaicin.
Regulation (effect) of SP associated with qutenza, antinociceptive and substance p
2) Confidence 0.20 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.24 Pain Relevance 1.84
We studied the importance of SP and NK-1R in this colitis model.
Regulation (importance) of SP associated with colitis and substance p
3) Confidence 0.11 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.53 Pain Relevance 0.62
Could SP be responsible for glutamate-independent feed-forward inhibition?
Regulation (responsible) of SP associated with glutamate and substance p
4) Confidence 0.08 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.12 Pain Relevance 1.44
The TG of Brn3a-/- newborn mice exhibit marked reduction in Trpm8, Mrga1, Mrgd and Scn11a, while CGRP and SP are minimally affected.
Regulation (affected) of SP associated with calcitonin gene related peptide and trigeminal ganglion
5) Confidence 0.07 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.46 Pain Relevance 0.92
The most significant alteration of the activity of SP was produced when Alexa 488 was added to SP.
Regulation (alteration) of SP associated with substance p
6) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.54
Capsaicin was found to increase IPSCs to a similar degree in animals with (Figure 4c) or without SP-SAP treatment (Figure 1g–j, Supplementary Figure 1), indicating that the ablation did not affect SP-driven FFI in lamina V.
Neg (not) Regulation (affect) of SP in lamina associated with qutenza and substance p
7) Confidence 0.04 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0.43 Pain Relevance 0.96
We suggest that the very strong anatomical relationship between primary afferent nociceptors that express SP and EM2 underlies an EM2 regulation of SP release via mu-opioid autoreceptors.
Regulation (regulation) of SP in nociceptors associated with nociceptor, opioid and substance p
8) Confidence 0.03 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15078552 Disease Relevance 0.07 Pain Relevance 1.02
Therefore, it is suggested that G:C to C:G transversions induced by particles such as C60, CB and kaolin could involve Oz, Sp and Gh formations.
Regulation (involve) of Sp
9) Confidence 0.03 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.12 Pain Relevance 0
Alexa 488, which was the largest and added the most charged groups to SP, was unable to label the SPR and altered the biological activity of SP in live and cultured cells.
Neg (unable) Regulation (altered) of SP associated with substance p
10) Confidence 0.03 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.34
In contrast, expression levels of mRNA for the Runx1-independent neuropeptides CGRP and Substance P/Tachykinin 1 (SP/Tac1) were little changed (Figure 3B), consistent with past results [16,17].
Neg (little) Regulation (changed) of SP associated with calcitonin gene related peptide, neuropeptide and substance p
11) Confidence 0.03 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.53 Pain Relevance 1.07
Further work determined if substance P (SP), a pro-inflammatory neuropeptide, participated in regulation of this response.
Regulation (regulation) of SP associated with inflammation, neuropeptide and substance p
12) Confidence 0.02 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15832292 Disease Relevance 0.68 Pain Relevance 0.49
The effects of SP and other tachykinins at the bfSPR have been previously well characterized [8, 9, 5].
Regulation (effects) of SP associated with substance p
13) Confidence 0.02 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.06 Pain Relevance 0.68
Oregon Green 488 and BODIPY FL-SP are the most useful fluorophores for labeling SP without affecting its biological activity.
Neg (without) Regulation (affecting) of SP associated with substance p
14) Confidence 0.02 Published 2001 Journal BMC Chem Biol Section Abstract Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.86
Subsequently, calcium imaging was performed [27], the effect of SP (100 nM) on EGFP neurons was tested.
Regulation (effect) of SP in neurons associated with imagery and substance p
15) Confidence 0.02 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0 Pain Relevance 0.41

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