INT70556

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Context Info
Confidence 0.34
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.13
Pain Relevance 12.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
dorsal root 2
nerve 2
neurons 2
spinal cord 2
lamina 2
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 382 100.00 Very High Very High Very High
Glutamate 62 100.00 Very High Very High Very High
qutenza 133 99.98 Very High Very High Very High
c fibre 47 99.90 Very High Very High Very High
antinociception 11 99.86 Very High Very High Very High
primary afferent fibers 31 99.76 Very High Very High Very High
Analgesic 15 99.40 Very High Very High Very High
Inflammation 37 99.32 Very High Very High Very High
Antinociceptive 22 99.00 Very High Very High Very High
Dorsal horn neuron 24 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 54 99.76 Very High Very High Very High
Neurogenic Inflammation 2 99.32 Very High Very High Very High
Hyperalgesia 47 98.90 Very High Very High Very High
Pain 108 92.64 High High
INFLAMMATION 31 92.36 High High
Hypersensitivity 3 91.20 High High
Bordatella Infection 6 81.52 Quite High
Targeted Disruption 9 70.04 Quite High
Sprains And Strains 5 69.48 Quite High
Inflammatory Pain 6 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin, which produces an initial hyperalgesic response followed by persistent antinociception, also elicits release of SP from primary afferent fibers.
Positive_regulation (elicits) of Localization (release) of SP associated with antinociception, hyperalgesia, qutenza, primary afferent fibers and substance p
1) Confidence 0.34 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.19 Pain Relevance 1.63
N-terminal metabolic fragments of SP that accumulate after capsaicin-induced SP release and are involved in the antinociceptive effect of capsaicin, were also tested.
Positive_regulation (induced) of Localization (release) of SP associated with qutenza, antinociceptive and substance p
2) Confidence 0.34 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.24 Pain Relevance 2.52
- and C- fibers, induces the release of both glutamate and SP, mainly in lamina I and V.
Positive_regulation (induces) of Localization (release) of SP in lamina associated with glutamate and substance p
3) Confidence 0.20 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.43 Pain Relevance 1.13
If an antinociceptive role for SP-driven feed-forward inhibition exists, the activation of SP release would have an analgesic effect in SP-SAP injected animals but blocking SP transmission would result in behavioral sensitization in SP-SAP injected animals.
Positive_regulation (activation) of Localization (release) of SP associated with analgesic, antinociceptive and substance p
4) Confidence 0.15 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.38 Pain Relevance 1.52
Gu and colleagues stimulated the dorsal root of the spinal cord, which contains primary afferent fibers, with high frequency stimulation to cause the release of both SP and glutamate in the presence of N-methyl-D-aspartate (NMDA) receptors and non-NMDA receptors antagonists.
Positive_regulation (cause) of Localization (release) of SP in dorsal root associated with glutamate, antagonist, nmda receptor, primary afferent fibers, substance p and spinal cord
5) Confidence 0.13 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.20 Pain Relevance 1.35
The release of SP from primary afferent neurons is increased during nociception, and SP activates neurokinin-1 (NK-1) receptors in the spinal cord and periphery.
Positive_regulation (increased) of Localization (release) of SP in spinal cord associated with nociception, spinal cord and substance p
6) Confidence 0.11 Published 2003 Journal Brain Res. Section Abstract Doc Link 12535787 Disease Relevance 0.59 Pain Relevance 0.47
We observed that primary afferent stimulation recruiting C-fibers was required for both SP and BDNF release and ERK activation in post-synaptic dorsal horn neurons.
Positive_regulation (required) of Localization (release) of SP in neurons associated with c fibre, dorsal horn neuron and substance p
7) Confidence 0.11 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 14572451 Disease Relevance 0 Pain Relevance 0.92
In these sites, lymphocyte extravasation is facilitated by neurogenic inflammation and plasma extravasation that is dependent on the release of SP from capsaicin-sensitive primary afferent nerve endings via an axon reflex.
Positive_regulation (dependent) of Localization (release) of SP in nerve associated with qutenza, inflammation, neurogenic inflammation and substance p
8) Confidence 0.02 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.43 Pain Relevance 0.75
After reintroducing the gene encoding SP into both types of C-fiber, capsaicin stimulation should lead to SP release both superficially and deep.
Positive_regulation (lead) of Localization (release) of SP associated with c fibre, qutenza and substance p
9) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2214810 Disease Relevance 0.67 Pain Relevance 1.83

General Comments

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