INT70557

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 7
Disease Relevance 1.15
Pain Relevance 17.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 161 100.00 Very High Very High Very High
qutenza 112 100.00 Very High Very High Very High
antinociception 28 99.96 Very High Very High Very High
primary afferent fibers 21 99.76 Very High Very High Very High
Antinociceptive 35 96.68 Very High Very High Very High
Spinal cord 21 94.96 High High
Pain 14 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 14 98.20 Very High Very High Very High
Hyperalgesia 7 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that antinociception does not appear to depend on decreases in SP release or content as antinociception precedes decreases in SP release.
Negative_regulation (decreases) of Localization (release) of SP associated with antinociception and substance p
1) Confidence 0.36 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.07 Pain Relevance 2.17
Capsaicin pretreatment decreases the content and release of SP from primary afferent fibers.
Negative_regulation (decreases) of Localization (release) of SP associated with qutenza, primary afferent fibers and substance p
2) Confidence 0.32 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.24 Pain Relevance 1.76
D-Substance P(1-7), which prevents antinociception, blocked capsaicin- and SP(1-7)-induced decreases in SP release, indicating that these effects are mediated by SP N-terminal activity.
Negative_regulation (decreases) of Localization (release) of SP associated with antinociception, qutenza and substance p
3) Confidence 0.32 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.14 Pain Relevance 2.69
In contrast, capsaicin-evoked SP release decreased significantly in tissue from mice pretreated with capsaicin or SP(1-7) 48 h prior to testing.
Negative_regulation (decreased) of Localization (release) of SP associated with qutenza and substance p
4) Confidence 0.32 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.21 Pain Relevance 2.84
These data indicate that antinociception does not appear to depend on decreases in SP release or content as antinociception precedes decreases in SP release.
Negative_regulation (decreases) of Localization (release) of SP associated with antinociception and substance p
5) Confidence 0.32 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.07 Pain Relevance 2.28
D-Substance P(1-7), which prevents antinociception, blocked capsaicin- and SP(1-7)-induced decreases in SP release, indicating that these effects are mediated by SP N-terminal activity.
Negative_regulation (blocked) of Localization (release) of SP associated with antinociception, qutenza and substance p
6) Confidence 0.32 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.19 Pain Relevance 2.75
However, at this time there was no decrease in capsaicin-evoked release of SP in tissue from capsaicin- and SP(1-7)-pretreated animals compared to those injected with vehicle.
Neg (no) Negative_regulation (decrease) of Localization (release) of SP associated with qutenza and substance p
7) Confidence 0.32 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.23 Pain Relevance 2.82

General Comments

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