INT70561

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Context Info
Confidence 0.27
First Reported 1997
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.03
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESRRB) nucleus (ESRRB) transcription factor binding (ESRRB)
Anatomy Link Frequency
adipocyte 1
ESRRB (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 2 97.88 Very High Very High Very High
Opioid 1 96.28 Very High Very High Very High
rapifen 4 88.00 High High
Hippocampus 12 70.72 Quite High
Neuropeptide 2 61.48 Quite High
Catecholamine 1 54.00 Quite High
amygdala 13 53.92 Quite High
Thalamus 2 51.28 Quite High
medulla 9 48.40 Quite Low
cINOD 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 11 99.84 Very High Very High Very High
Cancer 93 95.96 Very High Very High Very High
Stress 85 95.08 Very High Very High Very High
Liposarcoma 20 90.16 High High
Solid Tumor 1 83.44 Quite High
Prostate Cancer 15 80.24 Quite High
Reprotox - General 1 3 75.00 Quite High
Apoptosis 59 66.16 Quite High
Shock 1 47.28 Quite Low
Disease 58 45.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P450, 3A4 activity is higher in women, influenced by steroid hormone levels, and is speculated to vary during the menstrual cycle.
Regulation (influenced) of steroid hormone
1) Confidence 0.27 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9232131 Disease Relevance 0 Pain Relevance 0.28
It is possible that steroid hormone fluctuations influence the activation of gene transcription in target mammary cells.
Spec (possible) Regulation (influence) of steroid hormone
2) Confidence 0.03 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1143573 Disease Relevance 0.12 Pain Relevance 0
Human aldo-keto reductases (AKR) of the 1A, 1B, 1C and 1D subfamilies are involved in the pre-receptor regulation of nuclear (steroid hormone and orphan) receptors by regulating the local concentrations of their lipophilic ligands.
Regulation (regulation) of steroid hormone
3) Confidence 0.02 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16417966 Disease Relevance 0.07 Pain Relevance 0
in adipocyte differentiation has fueled intense interest in the function of this steroid nuclear receptor for regulation of malignant cell growth and differentiation.
Regulation (regulation) of steroid nuclear receptor in adipocyte associated with malignant neoplastic disease
4) Confidence 0.01 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2605846 Disease Relevance 0.59 Pain Relevance 0
Glucocorticoids activate steroid receptor mediated transcriptional regulation and membrane receptors, inducing changes which serve to mobilize energy and inhibit other potentially costly reactions to stress.
Regulation (regulation) of steroid receptor associated with stress
5) Confidence 0.01 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1629015 Disease Relevance 0.25 Pain Relevance 0.15

General Comments

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